Objective To discuss the relationship of cereb ral infarction with hyperhomocyste inemia and the relationship between hyperhomo-cysteinemia and folic acid and Vitam ine B 12 .Method We measured the concentrations of h...Objective To discuss the relationship of cereb ral infarction with hyperhomocyste inemia and the relationship between hyperhomo-cysteinemia and folic acid and Vitam ine B 12 .Method We measured the concentrations of homocysteine with FIPA(fluorescence polarization im-munoassay)and Vitamin B 12 and folic acid with chemiluminescen t competitive immunoassay in 40cere bral infarction patients and 30heal thy con-trols.Results The concentration of homocysteine i n study group was higher than the cont rols’ (P <0.01).Serum folic acid level in study grou p was lower than that in control group(P <0.05).There is negative correlation betw een plasma homocysteine and serum fo lic acid(P <0.05).Conclusions Hyperhomocysteinemia is an indepen dent risk factor of atherosclerotic cerebral infarction.One reason of i ncreased level of homocysteine in blood is that the deficiency of cofactors of enzymes involved in metabo lism process.展开更多
文摘Objective To discuss the relationship of cereb ral infarction with hyperhomocyste inemia and the relationship between hyperhomo-cysteinemia and folic acid and Vitam ine B 12 .Method We measured the concentrations of homocysteine with FIPA(fluorescence polarization im-munoassay)and Vitamin B 12 and folic acid with chemiluminescen t competitive immunoassay in 40cere bral infarction patients and 30heal thy con-trols.Results The concentration of homocysteine i n study group was higher than the cont rols’ (P <0.01).Serum folic acid level in study grou p was lower than that in control group(P <0.05).There is negative correlation betw een plasma homocysteine and serum fo lic acid(P <0.05).Conclusions Hyperhomocysteinemia is an indepen dent risk factor of atherosclerotic cerebral infarction.One reason of i ncreased level of homocysteine in blood is that the deficiency of cofactors of enzymes involved in metabo lism process.
