Objective:The violent death of a young parent from cancer has a profound effect on both spouse and children.The family must adapt to the absence of the bereaved and reorganize to raise the children as best they can.Ve...Objective:The violent death of a young parent from cancer has a profound effect on both spouse and children.The family must adapt to the absence of the bereaved and reorganize to raise the children as best they can.Very young children are particularly vulnerable,as they are generally unable to express their suffering.To give them a voice,we have designed an innovative system,The Little Match Girl,as part of a health democracy approach.Methods:We assessed the effects of their participation in the group for a population of eight children and their parents.The six parents assessed their child(ren)’s emotion regulation before and after therapy using the ERC-vf scale.The FACES IV enabled us to assess the cohesion and adaptability of each family.Results:All eight children showed improved emotion regulation.The program promotes family resilience.However,difficulties persist in rigid or disengaged families.Conclusion:We hope that other cancer centers will follow our model to give a place to very young children dealing with the death of a parent from cancer,and to encourage family empowerment.展开更多
As with many types of cancer,immunotherapy is changing the management of squamous cell carcinoma of the head and neck(HNSCC).In a locally advanced or metastatic setting,treatment options have long been curtailed,but t...As with many types of cancer,immunotherapy is changing the management of squamous cell carcinoma of the head and neck(HNSCC).In a locally advanced or metastatic setting,treatment options have long been curtailed,but this paradigm is currently changing.Checkpoint inhibitors were the first to be validated in second-line treatment with PD-1 and PD-L1 inhibitors and these treatments are available in USA for first-line use.In addition,many studies are underway to use its molecules earlier in the care or try to increase their effectiveness with associations.The issues of patient selection that would benefit the most from immunotherapy and the evaluation of the response to these treatments are not completely solved.The goal is here to update the possibilities of current treatment by immunotherapy in HNSCC as well as on various development pathways in progress.展开更多
Objectives.-To review and describe the anatomoclinical cases of the endometrial cancers arising on polyps during a hormonotherapy by tamoxifen for breast cancer. Patients and methods.-In the surgical inventory 1990-20...Objectives.-To review and describe the anatomoclinical cases of the endometrial cancers arising on polyps during a hormonotherapy by tamoxifen for breast cancer. Patients and methods.-In the surgical inventory 1990-2002 of the benign or malignant uterine lesions investigated by hysteroscopy with dilatation &curettage (D&C) and/or hysterectomy, 108 single or multiple endometrial polyps were encountered and histologically analyzed. Results.-A malignant transformation of polyp was found in 5 instances, meaning a rate of 4.6%i.e. 5/108: 4 cases of adenocarcinoma, 1 case of sarcoma. Discussion and conclusion.-The existence of endometrial polyps-symptomatic or not-does not seem compatible with the prolonged use of tamoxifen treatment owing the estrogen agonist potential effects of tamoxifen and its well-known hyperplastic and carcinogenic properties for the endometrium. The increased risk of endometrial cancer developing in polyps in this iatrogenic context is estimated between 2.5%and 10%in the literature.展开更多
文摘Objective:The violent death of a young parent from cancer has a profound effect on both spouse and children.The family must adapt to the absence of the bereaved and reorganize to raise the children as best they can.Very young children are particularly vulnerable,as they are generally unable to express their suffering.To give them a voice,we have designed an innovative system,The Little Match Girl,as part of a health democracy approach.Methods:We assessed the effects of their participation in the group for a population of eight children and their parents.The six parents assessed their child(ren)’s emotion regulation before and after therapy using the ERC-vf scale.The FACES IV enabled us to assess the cohesion and adaptability of each family.Results:All eight children showed improved emotion regulation.The program promotes family resilience.However,difficulties persist in rigid or disengaged families.Conclusion:We hope that other cancer centers will follow our model to give a place to very young children dealing with the death of a parent from cancer,and to encourage family empowerment.
文摘As with many types of cancer,immunotherapy is changing the management of squamous cell carcinoma of the head and neck(HNSCC).In a locally advanced or metastatic setting,treatment options have long been curtailed,but this paradigm is currently changing.Checkpoint inhibitors were the first to be validated in second-line treatment with PD-1 and PD-L1 inhibitors and these treatments are available in USA for first-line use.In addition,many studies are underway to use its molecules earlier in the care or try to increase their effectiveness with associations.The issues of patient selection that would benefit the most from immunotherapy and the evaluation of the response to these treatments are not completely solved.The goal is here to update the possibilities of current treatment by immunotherapy in HNSCC as well as on various development pathways in progress.
文摘Objectives.-To review and describe the anatomoclinical cases of the endometrial cancers arising on polyps during a hormonotherapy by tamoxifen for breast cancer. Patients and methods.-In the surgical inventory 1990-2002 of the benign or malignant uterine lesions investigated by hysteroscopy with dilatation &curettage (D&C) and/or hysterectomy, 108 single or multiple endometrial polyps were encountered and histologically analyzed. Results.-A malignant transformation of polyp was found in 5 instances, meaning a rate of 4.6%i.e. 5/108: 4 cases of adenocarcinoma, 1 case of sarcoma. Discussion and conclusion.-The existence of endometrial polyps-symptomatic or not-does not seem compatible with the prolonged use of tamoxifen treatment owing the estrogen agonist potential effects of tamoxifen and its well-known hyperplastic and carcinogenic properties for the endometrium. The increased risk of endometrial cancer developing in polyps in this iatrogenic context is estimated between 2.5%and 10%in the literature.
