Dear Editor,The outbreak of SARS-CoV-2 in minks has been observed recently,raising serious concerns over cross-species transmission and the emergence of variants capable of rendering antibody therapy and vaccines less...Dear Editor,The outbreak of SARS-CoV-2 in minks has been observed recently,raising serious concerns over cross-species transmission and the emergence of variants capable of rendering antibody therapy and vaccines less effective.Here,the species tropism and antigenicity of the spike protein of ten variants were analyzed in pseudovirus-based assays involving 25 cell lines as well as 293T cells expressing ACE2 receptor from 14 species.展开更多
基金the National Natural Science Foundation of China(grant number 82073621)the Bill&Melinda Gates Foundation[Investment ID INV-006379].
文摘Dear Editor,The outbreak of SARS-CoV-2 in minks has been observed recently,raising serious concerns over cross-species transmission and the emergence of variants capable of rendering antibody therapy and vaccines less effective.Here,the species tropism and antigenicity of the spike protein of ten variants were analyzed in pseudovirus-based assays involving 25 cell lines as well as 293T cells expressing ACE2 receptor from 14 species.
