Adaptive optics is becoming a valuable tool for high resolution microscopy,providing correction for aberrations introduced by the refractive index structure of specimens.This is proving particularly promising for appl...Adaptive optics is becoming a valuable tool for high resolution microscopy,providing correction for aberrations introduced by the refractive index structure of specimens.This is proving particularly promising for applications that require images from deep within biological tissue specimens.We review recent developments in adaptive microscopy,including methods and applications.A range of advances in different microscope modalities is covered and prospects for the future are discussed.展开更多
Long-term memory(LTM)allows animals to use remote past experiences to guide current and future decisions.One of the widely-used animal models for LTM research is the fruit-fly Drosophila melanogaster,which can form di...Long-term memory(LTM)allows animals to use remote past experiences to guide current and future decisions.One of the widely-used animal models for LTM research is the fruit-fly Drosophila melanogaster,which can form different types of LTM after different learning paradigms[1-6].Spaced training-induced LTM(spLTM),perhaps the most studied Drosophila LTM,requires multiple repeated learning trials with a 15-min resting interval between each trial.For decades,spLTM has been considered the only aversive olfactory LTM that can last for>7 days[1].Recently,two other types of LTM,context-dependent LTM(cLTM)[5]and merged LTM(mLTM)[6],have been discovered with the same long duration as spLTM,and can be formed with only one aversive learning trial.展开更多
基金This work was supported by the following grants:EPSRC(EP/E055818/1)BBSRC(BB/J020907/1)the Wellcome Trust(095927/A/11/Z)
文摘Adaptive optics is becoming a valuable tool for high resolution microscopy,providing correction for aberrations introduced by the refractive index structure of specimens.This is proving particularly promising for applications that require images from deep within biological tissue specimens.We review recent developments in adaptive microscopy,including methods and applications.A range of advances in different microscope modalities is covered and prospects for the future are discussed.
基金supported by granes from the National Science Foundation of China(31970955)and the Tsinghua-Peking Center for Life Sciences.
文摘Long-term memory(LTM)allows animals to use remote past experiences to guide current and future decisions.One of the widely-used animal models for LTM research is the fruit-fly Drosophila melanogaster,which can form different types of LTM after different learning paradigms[1-6].Spaced training-induced LTM(spLTM),perhaps the most studied Drosophila LTM,requires multiple repeated learning trials with a 15-min resting interval between each trial.For decades,spLTM has been considered the only aversive olfactory LTM that can last for>7 days[1].Recently,two other types of LTM,context-dependent LTM(cLTM)[5]and merged LTM(mLTM)[6],have been discovered with the same long duration as spLTM,and can be formed with only one aversive learning trial.
