The Yes-associated protein(YAP)is a downstream effector of the Hippo pathway and acts as a key transcription co-factor to regulate cell migration,proliferation,and survival.The Hippo pathway is evolutionarily conserve...The Yes-associated protein(YAP)is a downstream effector of the Hippo pathway and acts as a key transcription co-factor to regulate cell migration,proliferation,and survival.The Hippo pathway is evolutionarily conserved and controls tissue growth and organ size.Dysregulation and heterogeneity of this pathway are found in cancers,including oral squamous cell carcinoma(OSCC),leading to overexpression of YAP and its regulated proliferation machinery.The activity of YAP is associated with its nuclear expression and is negatively regulated by the Hippo kinase-mediated phosphorylation resulting in an induction of its cytoplasmic translocation.This review focuses on the role of YAP in OSCC in the context of cancer metastatic potential and highlights the latestfindings about the heterogeneity of YAP expression and its nuclear transcription activity in oral cancer cell lines.The review also discusses the potential target of YAP in oral cancer therapy and the recentfinding of the unprecedented role of the desmosomal cadherin desmoglein-3(DSG3)in regulating Hippo-YAP signaling.展开更多
Dear Editor,Influenza affects humans of all ages;however,elderly people have increased susceptibility to infections and are especially predisposed to complications.1 A number of global efforts have increased influenza...Dear Editor,Influenza affects humans of all ages;however,elderly people have increased susceptibility to infections and are especially predisposed to complications.1 A number of global efforts have increased influenza vaccination administration in elderly people to reduce complications,particularly when seasonal influenza infections peak.2 To date,much is known about how influenza infection and host immunity interact during pathogenesis,which has led to a number of vaccines.3,4 However,the impact of influenza vaccines in older people is modest.2 Hence,the underlying pathophysiological mechanisms responsible for the worsening of influenza infection in old age are still elusive.展开更多
A recent article by Grifoni et al.elegantly demonstrated the ability to measure and understand the human CD4+and CD8+T cell responses to SARS-CoV-2 infection.1 These findings highlighted below gave new insights into t...A recent article by Grifoni et al.elegantly demonstrated the ability to measure and understand the human CD4+and CD8+T cell responses to SARS-CoV-2 infection.1 These findings highlighted below gave new insights into the immunopathogenesis of COVID-19,the crossreactivity of the SARS-CoV-2 infections,the potential targets of T cells,and for vaccine design.展开更多
基金founded by Elfarouq Foundation(a small charity).
文摘The Yes-associated protein(YAP)is a downstream effector of the Hippo pathway and acts as a key transcription co-factor to regulate cell migration,proliferation,and survival.The Hippo pathway is evolutionarily conserved and controls tissue growth and organ size.Dysregulation and heterogeneity of this pathway are found in cancers,including oral squamous cell carcinoma(OSCC),leading to overexpression of YAP and its regulated proliferation machinery.The activity of YAP is associated with its nuclear expression and is negatively regulated by the Hippo kinase-mediated phosphorylation resulting in an induction of its cytoplasmic translocation.This review focuses on the role of YAP in OSCC in the context of cancer metastatic potential and highlights the latestfindings about the heterogeneity of YAP expression and its nuclear transcription activity in oral cancer cell lines.The review also discusses the potential target of YAP in oral cancer therapy and the recentfinding of the unprecedented role of the desmosomal cadherin desmoglein-3(DSG3)in regulating Hippo-YAP signaling.
文摘Dear Editor,Influenza affects humans of all ages;however,elderly people have increased susceptibility to infections and are especially predisposed to complications.1 A number of global efforts have increased influenza vaccination administration in elderly people to reduce complications,particularly when seasonal influenza infections peak.2 To date,much is known about how influenza infection and host immunity interact during pathogenesis,which has led to a number of vaccines.3,4 However,the impact of influenza vaccines in older people is modest.2 Hence,the underlying pathophysiological mechanisms responsible for the worsening of influenza infection in old age are still elusive.
基金supported by Talent Program of Qingdao Agricultural University and Priority Academic Talent Team Cultivation Program of Shandong Colleges(J.L and J.W)supported by Global Engagement Research Initiation(GERI QMUL)and Medical Charity of Barts Hospital Trustee award to A.S.K.
文摘A recent article by Grifoni et al.elegantly demonstrated the ability to measure and understand the human CD4+and CD8+T cell responses to SARS-CoV-2 infection.1 These findings highlighted below gave new insights into the immunopathogenesis of COVID-19,the crossreactivity of the SARS-CoV-2 infections,the potential targets of T cells,and for vaccine design.
