AIM: To explore the optimal interval of intraocular pressure(IOP) measurement for screening glaucoma in healthy people.METHODS: From January to December 2005, we consecutively enrolled all participants(> 20 years o...AIM: To explore the optimal interval of intraocular pressure(IOP) measurement for screening glaucoma in healthy people.METHODS: From January to December 2005, we consecutively enrolled all participants(> 20 years old) attending the Center for Preventive Medicine at St. Luke's International Hospital in Tokyo, Japan, for the annual health check program. The program promoted the early detection of chronic diseases and their risk factors. We excluded people who had glaucoma or a high IOP(≥ 22 mm Hg) at baseline. The annual health check-ups collected all demographic information and medical history with an initial evaluation, including IOP measurement. IOP was measured in both eyes with a full autotonometer TX-F(Canon, Tokyo, Japan). Participants with an IOP ≥ 22 mmH g in either eye were considered to require additional evaluation for glaucoma. We divided the participants into two groups based on age: under 65 years old and over 65 years old. The United States Department of Health and Human Services Cen-ters for Medicare and Medicaid Services guideline was used as a reference. RESULTS: From January 2005 to July 2008, 12 385 participants underwent check-ups each year. The mean ± SD IOP in the higher eye at baseline was 13.4(2.6) in 2005, 13.2(2.7) in 2006, 13.3(2.6), and 12.8(2.6) in 2008. In addition, we analyzed the differences with an analysis of variance(ANOVA), and additional analysis was performed with Bonferroni's correction. The difference between the 4 years was significant(P < 0.01) with ANOVA. Bonferroni analysis revealed significant differences between 2005 and 2006(P < 0.01), 2005 and 2008(P < 0.01), 2006 and 2007(P < 0.01), 2006 and 2008(P < 0.01), and 2007 and 2008(P < 0.01). Only the difference between 2005 and 2007 was not significant(P = 0.1). Logistic regression suggested that only age(P < 0.01) and baseline IOP(P < 0.01) were associated with high IOP; the presence of diabetes, HgbA 1c level, gender, systolic blood pressure, diastolic blood pressure, low-density lipoprotein and family history were non-significant.CONCLUSION: Annual IOP check-ups may be recommended for participants aged ≥ 65 years with baseline IOPs of 17-21 mm Hg. A check-up every 3 years or more may be recommended for patients with IOPs < 17 mmH g.展开更多
在报告评估研究时,我们缺乏关于描述人口健康和政策(population health and policy,PHP)干预措施方面的指南。PHP干预措施包括法律、财政、结构、组织、环境和政策方面的干预,例如对不健康商品的监管、卫生服务的重组、福利政策的调整...在报告评估研究时,我们缺乏关于描述人口健康和政策(population health and policy,PHP)干预措施方面的指南。PHP干预措施包括法律、财政、结构、组织、环境和政策方面的干预,例如对不健康商品的监管、卫生服务的重组、福利政策的调整和社区改善计划。许多PHP干预措施具有的一些特征,对其实施和成功至关重要,但在原来的干预描述和复制模板(Template for Intervention Description and Replication, TIDieR)清单中没有充分体现出来。本文介绍了PHP干预报告模板(TIDieR-PHP)的开发,并给出了项目清单和示例。展开更多
十年前,针对医学研究、教育和实践中的利益冲突问题,美国医学研究所(Institute of Medicine, IOM)颁布了一份具有划时代意义的报告。针对临床医生、研究人员和企业合作研发新产品的行为,这份报告强调了他们对健康事业进步带来的推动作用...十年前,针对医学研究、教育和实践中的利益冲突问题,美国医学研究所(Institute of Medicine, IOM)颁布了一份具有划时代意义的报告。针对临床医生、研究人员和企业合作研发新产品的行为,这份报告强调了他们对健康事业进步带来的推动作用,但同时也提出担忧——广泛存在的商业关联会对专业性判断产生过度的影响。展开更多
文摘AIM: To explore the optimal interval of intraocular pressure(IOP) measurement for screening glaucoma in healthy people.METHODS: From January to December 2005, we consecutively enrolled all participants(> 20 years old) attending the Center for Preventive Medicine at St. Luke's International Hospital in Tokyo, Japan, for the annual health check program. The program promoted the early detection of chronic diseases and their risk factors. We excluded people who had glaucoma or a high IOP(≥ 22 mm Hg) at baseline. The annual health check-ups collected all demographic information and medical history with an initial evaluation, including IOP measurement. IOP was measured in both eyes with a full autotonometer TX-F(Canon, Tokyo, Japan). Participants with an IOP ≥ 22 mmH g in either eye were considered to require additional evaluation for glaucoma. We divided the participants into two groups based on age: under 65 years old and over 65 years old. The United States Department of Health and Human Services Cen-ters for Medicare and Medicaid Services guideline was used as a reference. RESULTS: From January 2005 to July 2008, 12 385 participants underwent check-ups each year. The mean ± SD IOP in the higher eye at baseline was 13.4(2.6) in 2005, 13.2(2.7) in 2006, 13.3(2.6), and 12.8(2.6) in 2008. In addition, we analyzed the differences with an analysis of variance(ANOVA), and additional analysis was performed with Bonferroni's correction. The difference between the 4 years was significant(P < 0.01) with ANOVA. Bonferroni analysis revealed significant differences between 2005 and 2006(P < 0.01), 2005 and 2008(P < 0.01), 2006 and 2007(P < 0.01), 2006 and 2008(P < 0.01), and 2007 and 2008(P < 0.01). Only the difference between 2005 and 2007 was not significant(P = 0.1). Logistic regression suggested that only age(P < 0.01) and baseline IOP(P < 0.01) were associated with high IOP; the presence of diabetes, HgbA 1c level, gender, systolic blood pressure, diastolic blood pressure, low-density lipoprotein and family history were non-significant.CONCLUSION: Annual IOP check-ups may be recommended for participants aged ≥ 65 years with baseline IOPs of 17-21 mm Hg. A check-up every 3 years or more may be recommended for patients with IOPs < 17 mmH g.
基金There was no funding for the development of TIDieR-PHPMC and PC are supported by the UK Medical Research Council/Chief Scientist Office Informing Healthy Public Policy programme(MC_UU_12017-15 and SPHSU15)+1 种基金SVK is supported by an NHS Research Scotland Scottish Senior Clinical Fellowship(SCAF/15/02)RAis supported by the Jack Brockhoff Child Health and Wellbeing Program.
文摘在报告评估研究时,我们缺乏关于描述人口健康和政策(population health and policy,PHP)干预措施方面的指南。PHP干预措施包括法律、财政、结构、组织、环境和政策方面的干预,例如对不健康商品的监管、卫生服务的重组、福利政策的调整和社区改善计划。许多PHP干预措施具有的一些特征,对其实施和成功至关重要,但在原来的干预描述和复制模板(Template for Intervention Description and Replication, TIDieR)清单中没有充分体现出来。本文介绍了PHP干预报告模板(TIDieR-PHP)的开发,并给出了项目清单和示例。
文摘十年前,针对医学研究、教育和实践中的利益冲突问题,美国医学研究所(Institute of Medicine, IOM)颁布了一份具有划时代意义的报告。针对临床医生、研究人员和企业合作研发新产品的行为,这份报告强调了他们对健康事业进步带来的推动作用,但同时也提出担忧——广泛存在的商业关联会对专业性判断产生过度的影响。
