Nucleosomal histone tails are subject to a vast repertoire of covalent modifications that alter the physical accessibility of their associated DNA,impacting gene expression.Specifically,the acetylation of histones is ...Nucleosomal histone tails are subject to a vast repertoire of covalent modifications that alter the physical accessibility of their associated DNA,impacting gene expression.Specifically,the acetylation of histones is associated with transcriptional activation,as it has been shown to reduce their affinity for DNA(Grant,2001).The dynamic changes on histone acetylation levels throughout development are the result of active acetylation and deacetylation processes,mediated by histone acetyltransferases(HATs)and deacetylases,respectively.展开更多
The physical accessibility of specific genomic regions is a chromatin property that regulates gene expression and allows the establishment of an appropriate transcriptional landscape in response to environmental and d...The physical accessibility of specific genomic regions is a chromatin property that regulates gene expression and allows the establishment of an appropriate transcriptional landscape in response to environmental and developmental signals.In eukaryotes,ATP-dependent chromatin remodeling complexes use the energy produced via ATP hydrolysis by an ATPase subunit to perform DNA translocation.These complexes are classified into four subfamilies,based on the domain organization of their catalytic ATPases(Clapier et al.,2017).展开更多
文摘Nucleosomal histone tails are subject to a vast repertoire of covalent modifications that alter the physical accessibility of their associated DNA,impacting gene expression.Specifically,the acetylation of histones is associated with transcriptional activation,as it has been shown to reduce their affinity for DNA(Grant,2001).The dynamic changes on histone acetylation levels throughout development are the result of active acetylation and deacetylation processes,mediated by histone acetyltransferases(HATs)and deacetylases,respectively.
文摘The physical accessibility of specific genomic regions is a chromatin property that regulates gene expression and allows the establishment of an appropriate transcriptional landscape in response to environmental and developmental signals.In eukaryotes,ATP-dependent chromatin remodeling complexes use the energy produced via ATP hydrolysis by an ATPase subunit to perform DNA translocation.These complexes are classified into four subfamilies,based on the domain organization of their catalytic ATPases(Clapier et al.,2017).
