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Effects of Rheum tanguticum polysaccharide on TNBS-induced colitis and CD4^+T cells in rats 被引量:18
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作者 LiLiu Zhi-PengWang +5 位作者 Chang-TaiXu Bo-RongPan Qi-BingMei YinLong Jia-YunLiu Si-YuanZhou 《World Journal of Gastroenterology》 SCIE CAS CSCD 2003年第10期2284-2288,共5页
AIM: To study the effects of Rheum tanguticum polysaccharide-1 (RTP-1) on ulcerative colitis in rats induced by 2, 4, 6-trinitrophene sulphonic acid (TNBS) and their possible mechanism.METHODS: RTP1 (200 mg@kg-1, ig) ... AIM: To study the effects of Rheum tanguticum polysaccharide-1 (RTP-1) on ulcerative colitis in rats induced by 2, 4, 6-trinitrophene sulphonic acid (TNBS) and their possible mechanism.METHODS: RTP1 (200 mg@kg-1, ig) extracted from Rheum tanguticum Maxim. Ex Regel was administrated to rats with colitis induced by TNBS for 5 d, 7 d, 10 d and 14 d,respectively. The effects of RTP1 and dexamethasone (DX,0.2 mg@kg-1, ig) were contrastively investigated. The MPO level and SOD activity were determined by chromatometry.The expansion and protein expression of CD4+T lymphocytes isolated from colon mucosae and mesenteric lymph nodes of colitis rats were performed by immunohistochemical analysis and Western-blot methods.RESULTS: Treatments of RTP1 (200 mg@kg-1, ig) significantly reduced diarrhea, mortality, colon mass, ulcer areas and MPO level in colon mucosae on days 5, 7, 10 and 14 (5.2±1.4,5.4±0.7, 5.2±1.8, P<0.05.3.4±0.8, P<0.01. 16.1±12.1,P<0.01.31.8±8.6, 17.7±5.3, 12.7±4.1, P<0.05). The effectsof RTP1 were similar to those noted above in DX group, but there were no immunosupressive effects of DX in RTP-1group, such as body mass loss, thymus and spleen atrophy.The decreased number and down-regulated protein levels of CD4+T cells isolated from the colon of colitis rats treated with RTP1 were found.CONCLUSION: RTP1 shows significantly protective effects but lower side effects on rats with colitis induced by TNBS.The mechanism may be due to the resistance to over expansion of CD4. 展开更多
关键词 T淋巴细胞 CD4+ 大肠炎 RTP.1 药理作用 动物实验
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