To the editor： Beijing has begun implementing its new public hospital reform programs since July 1, 2012.1 According to the new policies, patients are charged a medical care service fee which varies according to doc...To the editor： Beijing has begun implementing its new public hospital reform programs since July 1, 2012.1 According to the new policies, patients are charged a medical care service fee which varies according to doctor＇s seniority while the 15 percent of drug markup is eliminated, aiming at reducing hospitals＇ dependency on profits from drug prescriptions and fine-tuning the structure of hospitals＇ incomes.展开更多
Objective To investigate the relationship between body mass index(BMI)and osteoporosis using Mendelian randomization analysis.Methods The genetic variation strongly related to BMI was selected as the instrumental vari...Objective To investigate the relationship between body mass index(BMI)and osteoporosis using Mendelian randomization analysis.Methods The genetic variation strongly related to BMI was selected as the instrumental variables in the collection data set of the genome-wide association study(GWAS).The MR-Egger regression,weighted median estimator(WME),inverse variance weighted(IVW),simple mode and weighted mode were used for Mendelian randomization(MR)analysis.The causal association between BMI and osteoporosis was evaluated by odds ratio and 95%confidence interval.The MR-APSS method was applied to make the causal inference results based on MRRmore reliable.The Linkage disequilibrium score regression was applied to evaluate the genetic correlation,and the horizontal pleiotropy test,heterogeneity test,and leave-one-out method were used to evaluate whether the results were reliable.展开更多
Objective To observe the effects of Dioscornin Tablet (DT) containing serum on nuclear factor of kappa B (NF-κB) p65,signal transducer and activator of transcription 3 (STAT3) ,and vascular endothelial growth factor ...Objective To observe the effects of Dioscornin Tablet (DT) containing serum on nuclear factor of kappa B (NF-κB) p65,signal transducer and activator of transcription 3 (STAT3) ,and vascular endothelial growth factor (VEGF) mRNA expressions in rats’synovial展开更多
Objective To investigate the effect of aortic valvecalcification (AVC) on the clinical characteristics andprognosis of patients with acute coronary syndrome( ACS ) undergoing percutaneous coronary intervention(PCI). M...Objective To investigate the effect of aortic valvecalcification (AVC) on the clinical characteristics andprognosis of patients with acute coronary syndrome( ACS ) undergoing percutaneous coronary intervention(PCI). Methods A total of 68 ACS inpatients with echocardiographicAVC and 106 ACS controls without AVCundergone PCI were consecutively enrolled from January2014 to January 2016 in the division of cardiology in ourhospital. The clinical and angiographic data of the patientswere collected and followed up for two years by twocardiology physicians. Results The prevalences of dyslipidemia(77. 9% vs 38. 7%),type 2 diabetes mellitus(47. 1% vs 24. 5%) and arrhythmia ( 37. 3% vs15. 2%) were significantly higher in the AVC group thanin the control goup ( all P < 0. 05 ). In addition,theGensini score was significantly higher in the AVC groupthan in the control goup (P < 0. 05).展开更多
Objective To study the changes of serum levels of Irisin and Galanin in patients with type 2 diabetes mellitus and obesity. Methods A total of 182 patients with type 2 diabetes (T2DM) hospitalized in Endocrinology and...Objective To study the changes of serum levels of Irisin and Galanin in patients with type 2 diabetes mellitus and obesity. Methods A total of 182 patients with type 2 diabetes (T2DM) hospitalized in Endocrinology and Metabolism Department in Baoding First Center Hospital were enrolled in this study. All the patients were divided into three groups according to their BMI: normal weight group (NW), diabetic overweight group (OW) and diabetes and obesity group (OB).展开更多
Objective To clarify the effects of bortezomib combined with or without siramesine on the proliferation of multiple myeloma cell lines,the expression changes of transcription factor EBC(TFEB)nuclear translocation and ...Objective To clarify the effects of bortezomib combined with or without siramesine on the proliferation of multiple myeloma cell lines,the expression changes of transcription factor EBC(TFEB)nuclear translocation and the level of autophagy,and to provide basis for further exploring the regulation mechanism of transcription factor TFEB on autophagy.展开更多
Objective To explore the correlation between the levels of glycosylated albumin(GA),HbA_(1)c and GA/HbA_(1)c in patients with T2DM complicated with coronary heart disease(CAD).Methods From January 2018 to December 202...Objective To explore the correlation between the levels of glycosylated albumin(GA),HbA_(1)c and GA/HbA_(1)c in patients with T2DM complicated with coronary heart disease(CAD).Methods From January 2018 to December 2021,596 patients with T2DM hospitalized in the Department of Endocrinology,Affiliated Hospital of Chengde Medical College were selected and divided into simple T2DM group(T2DM,n=304)and T2DM combined with CAD group(CAD,n=292).展开更多
文摘To the editor： Beijing has begun implementing its new public hospital reform programs since July 1, 2012.1 According to the new policies, patients are charged a medical care service fee which varies according to doctor＇s seniority while the 15 percent of drug markup is eliminated, aiming at reducing hospitals＇ dependency on profits from drug prescriptions and fine-tuning the structure of hospitals＇ incomes.
文摘Objective To investigate the relationship between body mass index(BMI)and osteoporosis using Mendelian randomization analysis.Methods The genetic variation strongly related to BMI was selected as the instrumental variables in the collection data set of the genome-wide association study(GWAS).The MR-Egger regression,weighted median estimator(WME),inverse variance weighted(IVW),simple mode and weighted mode were used for Mendelian randomization(MR)analysis.The causal association between BMI and osteoporosis was evaluated by odds ratio and 95%confidence interval.The MR-APSS method was applied to make the causal inference results based on MRRmore reliable.The Linkage disequilibrium score regression was applied to evaluate the genetic correlation,and the horizontal pleiotropy test,heterogeneity test,and leave-one-out method were used to evaluate whether the results were reliable.
文摘Objective To observe the effects of Dioscornin Tablet (DT) containing serum on nuclear factor of kappa B (NF-κB) p65,signal transducer and activator of transcription 3 (STAT3) ,and vascular endothelial growth factor (VEGF) mRNA expressions in rats’synovial
文摘Objective To investigate the effect of aortic valvecalcification (AVC) on the clinical characteristics andprognosis of patients with acute coronary syndrome( ACS ) undergoing percutaneous coronary intervention(PCI). Methods A total of 68 ACS inpatients with echocardiographicAVC and 106 ACS controls without AVCundergone PCI were consecutively enrolled from January2014 to January 2016 in the division of cardiology in ourhospital. The clinical and angiographic data of the patientswere collected and followed up for two years by twocardiology physicians. Results The prevalences of dyslipidemia(77. 9% vs 38. 7%),type 2 diabetes mellitus(47. 1% vs 24. 5%) and arrhythmia ( 37. 3% vs15. 2%) were significantly higher in the AVC group thanin the control goup ( all P < 0. 05 ). In addition,theGensini score was significantly higher in the AVC groupthan in the control goup (P < 0. 05).
文摘Objective To study the changes of serum levels of Irisin and Galanin in patients with type 2 diabetes mellitus and obesity. Methods A total of 182 patients with type 2 diabetes (T2DM) hospitalized in Endocrinology and Metabolism Department in Baoding First Center Hospital were enrolled in this study. All the patients were divided into three groups according to their BMI: normal weight group (NW), diabetic overweight group (OW) and diabetes and obesity group (OB).
文摘Objective To clarify the effects of bortezomib combined with or without siramesine on the proliferation of multiple myeloma cell lines,the expression changes of transcription factor EBC(TFEB)nuclear translocation and the level of autophagy,and to provide basis for further exploring the regulation mechanism of transcription factor TFEB on autophagy.
文摘Objective To explore the correlation between the levels of glycosylated albumin(GA),HbA_(1)c and GA/HbA_(1)c in patients with T2DM complicated with coronary heart disease(CAD).Methods From January 2018 to December 2021,596 patients with T2DM hospitalized in the Department of Endocrinology,Affiliated Hospital of Chengde Medical College were selected and divided into simple T2DM group(T2DM,n=304)and T2DM combined with CAD group(CAD,n=292).
