期刊文献+
共找到6篇文章
< 1 >
每页显示 20 50 100
Management of adults with coarctation of aorta 被引量:9
1
作者 Pradyumna Agasthi Sai Harika Pujari +6 位作者 Andrew Tseng Joseph N Graziano Francois Marcotte David Majdalany Farouk Mookadam Donald J Hagler Reza Arsanjani 《World Journal of Cardiology》 CAS 2020年第5期167-191,共25页
Coarctation of the aorta(CoA)is a relatively common congenital cardiac defect often causing few symptoms and therefore can be challenging to diagnose.The hallmark finding on physical examination is upper extremity hyp... Coarctation of the aorta(CoA)is a relatively common congenital cardiac defect often causing few symptoms and therefore can be challenging to diagnose.The hallmark finding on physical examination is upper extremity hypertension,and for this reason,CoA should be considered in any young hypertensive patient,justifying measurement of lower extremity blood pressure at least once in these individuals.The presence of a significant pressure gradient between the arms and legs is highly suggestive of the diagnosis.Early diagnosis and treatment are important as long-term data consistently demonstrate that patients with CoA have a reduced life expectancy and increased risk of cardiovascular complications.Surgical repair has traditionally been the mainstay of therapy for correction,although advances in endovascular technology with covered stents or stent grafts permit nonsurgical approaches for the management of older children and adults with native CoA and complications.Persistent hypertension and vascular dysfunction can lead to an increased risk of coronary disease,which,remains the greatest cause of long-term mortality.Thus,blood pressure control and periodic reassessment with transthoracic echocardiography and threedimensional imaging(computed tomography or cardiac magnetic resonance)for should be performed regularly as cardiovascular complications may occur decades after the intervention. 展开更多
关键词 Coarctation of aorta Cardiac surgery Cardiac catheterization Balloon angioplasty STENTS
下载PDF
先天性心脏病导管介人性治疗的现状
2
作者 W.Radtke 陈继华 《德国医学》 1996年第4期223-225,共3页
在过去的10年里,先天性心脏病(先心病)的治疗发生了重大的变化,复杂性先心病的手术治疗得到明显的改善,单纯的先心病也可不用手术来矫正。随着外科手术朝着复杂性手术和'早期手术'发展,心导管实验室的作用也相应由诊断转为治疗... 在过去的10年里,先天性心脏病(先心病)的治疗发生了重大的变化,复杂性先心病的手术治疗得到明显的改善,单纯的先心病也可不用手术来矫正。随着外科手术朝着复杂性手术和'早期手术'发展,心导管实验室的作用也相应由诊断转为治疗。目前,在 Kiel 展开更多
关键词 先天性心脏病 介入疗法 球囊扩张术
下载PDF
Transcriptional Profile Alteration of Peripheral Blood in Chronic Hypoxia
3
作者 Tingting Wang Junyue Xing +1 位作者 Lijing Zhang Hao Zhang 《Chinese Medical Sciences Journal》 CAS CSCD 2020年第1期54-64,共11页
Objective Many physiological and pathological conditions,including cyanotic congenital heart diseases(CCHD),are accompanied by chronic hypoxia,which might interfere with the transcription process.However,the transcrip... Objective Many physiological and pathological conditions,including cyanotic congenital heart diseases(CCHD),are accompanied by chronic hypoxia,which might interfere with the transcription process.However,the transcriptome profile in peripheral blood under hypoxia is still unidentified.The present work aimed to explore the transcriptional profile alteration of peripheral blood in chronic hypoxia.Methods The present study used a chronic hypoxia rat model to simulate the hypoxic state of CCHD patients.Two groups of Sprague-Dawley rats(n=6 per group)were either exposed to hypoxia(10%O2)or normoxia(21%O2)for 3 weeks.Body weight was measured weekly.Peripheral blood was collected and total RNA was extracted for RNA-Seq at the end of the hypoxia treatment.After quality assessment,the library was sequenced by the Illumina Hiseq platform.The differentially expressed genes were screened(false discovery rate<0.05 and fold change>2).The functional annotation analysis and cluster analysis of differentially expressed genes were performed based on the adjusted P-value(padj<0.05).Results Compared with the control group,the body weight of the rats in the hypoxia group was significantly lowered(P<0.01).RNA-Seq results showed that the transcriptome patterns of the two groups had significant differences.In total,872 genes were identified as differentially expressed.Among all,803 genes were downregulated,while only 69 genes were up-regulated in the hypoxia group.The functional enrichment analysis of the 872 genes showed that multiple biological processes involved,such as porphyrin-containing compound metabolic process,hemoglobin complex and oxygen transporter activity.Conclusions Our study demonstrated the transcriptional profile alteration in peripheral blood of chronic hypoxia rat model.This study provided basic data and directions to further understand the physiological and pathological changes in patients with CCHD. 展开更多
关键词 chronic HYPOXIA RNA-Seq PERIPHERAL blood CYANOTIC CONGENITAL heart diseases
下载PDF
Gore—Tax心外管道治疗先天性心脏病单心室95例临床体会
4
作者 付松 Prof. Dr. D. Schranz 封志纯 《中国综合临床》 2013年第4期405-408,共4页
目的总结Gore—Tax心外管道治疗先天性心脏病单心室的临床体会,探讨心外管道开窗术的治疗效果。方法1996年6月至2010年7月我们对95例先天性心脏病单心室患儿行心外管道纠治术治疗,71例行心外管道开窗术(开窗组),其中58例(58/71... 目的总结Gore—Tax心外管道治疗先天性心脏病单心室的临床体会,探讨心外管道开窗术的治疗效果。方法1996年6月至2010年7月我们对95例先天性心脏病单心室患儿行心外管道纠治术治疗,71例行心外管道开窗术(开窗组),其中58例(58/71)术前高风险患儿术中行开窗术,13例(13/71)患儿因术后低心排行介入开窗术;24例(24/95)术中未行心外管道开窗术(非开窗组)。结果开窗组无死亡;非开窗组死亡3例。开窗组术后胸腔引流时间平均(10.0±3.2)d,非开窗组平均(14.2±2.3)d,差异有统计学意义(P=0.016);开窗组术后平均肺动脉压(13.2±2.8)mmHg,非开窗组(15.1±3.4)mmHg,差异有统计学意义(P=0.017);开窗组及非开窗组术后血氧饱和度[(90.3±4.0)%、(91.7±5.2)%]、术后血栓[11.3%(8/71)、12.5%(3/24)]及心律失常发生率[18.3%(13/71)、20.8%(5/24)]相比差异均无统计学意义(P均〉0.05)。结论Gore—Tax心外管道术式治疗先天性心脏病单心室安全、有效;心外管道通过开窗术增加左心室的心输出量,从而降低术后早期病死率。 展开更多
关键词 先天性心脏病 心外管道 单心室 开窗术
原文传递
The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism 被引量:3
5
作者 Shiyan Song Yefei Wen +8 位作者 Hui Tong Emanuele Loro Yingyun Gong Jidong Liu Sungguan Hong Lei Li Tejvir S.Khurana Maoping Chu Zheng Sun 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2019年第2期133-143,共11页
Histone deacetylase 3 (HDAC3) is a major HDAC, whose enzymatic activity is targeted by small molecule inhibitors for treating a variety of conditions. However, its enzymatic activity is largely dispensable for its fun... Histone deacetylase 3 (HDAC3) is a major HDAC, whose enzymatic activity is targeted by small molecule inhibitors for treating a variety of conditions. However, its enzymatic activity is largely dispensable for its function in embryonic development and hepatic lipid metabolism.HDAC3 plays a pivotal role in regulating muscle fuel metabolism and contractile function. Here, we address whether these muscular functions of HDAC3 require its enzymatic activity. By mutating the NCoR/SMRT corepressors in a knock - in mouse model named NS-DADm, we ablated the enzymatic activity of HDAC3 without affecting its protein levels. Compared to the control mice, skeletal muscles from NS-DADm mice showed lower force generation, enhanced fatigue resistance, enhanced fatty acid oxidation, reduced glucose uptake during exercise, upregulated expression of metabolic genes involved in branchedchain amino acids catabolism, and reduced muscle mass during aging, without changes in the muscle fiber-type composition or mitochondrial protein content. These muscular phenotypes are similar to those observed in the HDAC3-depleted skeletal muscles, which demonstrates that, unlike that in the liver or embryonic development, the metabolic function of HDAC3 in skeletal muscles requires its enzymatic activity. These results suggest that drugs specifically targeting HDAC3 enzyme activity could be developed and tested to modulate muscle energy metabolism and exercise performance. 展开更多
关键词 HDAC muscle METABOLISM nuclear receptor COREPRESSOR HISTONE DEACETYLATION
原文传递
Fontan extracardiac tunnel connection: fenestration or not? 被引量:2
6
作者 Fu Song Valeske Klaus +1 位作者 Akinturk Hakan Schranz Dietmar 《Chinese Medical Journal》 SCIE CAS CSCD 2009年第19期2335-2338,共4页
Background The fenestration function is by allowing a right-to-left shunt resulting in an increased cardiac index, associated with mild arterial oxygen desaturation. Subsequent transcatheter fenestration closure can b... Background The fenestration function is by allowing a right-to-left shunt resulting in an increased cardiac index, associated with mild arterial oxygen desaturation. Subsequent transcatheter fenestration closure can be performed after haemodynamic assessment. The purpose of this study was to compare the outcomes of extracardiac connection (EC) with or without fenestration. Methods Ninety-five consecutive patients diagnosed with univentricular heart disease underwent EC using Gore-Tax conduits at the Department of Children's Heart Center, Justus-Liebig-University Giessen Germany from June 1996 to July 2007. According to EC with or without fenestration, the patients were assigned to two groups (group A with fenestration and group B without fenestration). Mortality, effusions, postoperative mean pulmonary artery pressure, postoperative oxygen saturation, postoperative thrombosis, postoperative neurological problems, and the postoperative loss of sinus rhythm were compared. In group A, 23 patients had fenestration closed interventionally after a mean time of 20-22 months. Results Mortality and postoperative mean pulmonary artery pressure in group B (3 and (15.1±3.4) mmHg, respectively) were significantly higher than group A (0 and (13.2±2.8) mmHg, respectively). Postoperative oxygen saturation, postoperative thrombosis, postoperative neurological problems, and the postoperative loss of sinus rhythm did not differ between cohorts. Conclusions Fenestrating an extracardiac tunnel seems to improve acute postoperative mortality by rising cardiac output. The induced right-to-left shunt shows no morbidity postoperatively. If a stabilized chronic hemodynamic situation is achieved, an interventional closure of the fenestration can be performed to advance the arterial saturation and improve the exercise tolerance of the patients. 展开更多
关键词 Fontan tunnel extracardiac connection univentricular heart FENESTRATION
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部