Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese medicine and Western medicine

Integrated traditional Chinese medicine(TCM)and Western medicine(WM)is a new medical science grounded in the knowledge bases of both TCM and WM,which then forms a unique modern medical system in China.Integrated TCM and WM has a long history in China,and has made important achievements in the process of clinical diagnosis and treatment.However,the methodological defects in currently published clinical practice guidelines(CPGs)limit its development.The organic integration of TCM and WM is a deeper integration of TCM and WM.To realize the progression of"integration"to"organic integration",a targeted and standardized guideline development methodology is needed.Therefore,the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.

Diabetic vascular diseases:molecular mechanisms and therapeutic strategies

Vascular complications of diabetes pose a severe threat to human health.Prevention and treatment protocols based on a single vascular complication are no longer suitable for the long-term management of patients with diabetes.Diabetic panvascular disease(DPD)is a clinical syndrome in which vessels of various sizes,including macrovessels and microvessels in the cardiac,cerebral,renal,ophthalmic,and peripheral systems of patients with diabetes,develop atherosclerosis as a common pathology.Pathological manifestations of DPDs usually manifest macrovascular atherosclerosis,as well as microvascular endothelial function impairment,basement membrane thickening,and microthrombosis.Cardiac,cerebral,and peripheral microangiopathy coexist with microangiopathy,while renal and retinal are predominantly microangiopathic.The following associations exist between DPDs:numerous similar molecular mechanisms,and risk-predictive relationships between diseases.Aggressive glycemic control combined with early comprehensive vascular intervention is the key to prevention and treatment.In addition to the widely recommended metformin,glucagon-like peptide-1 agonist,and sodium-glucose cotransporter-2 inhibitors,for the latest molecular mechanisms,aldose reductase inhibitors,peroxisome proliferator-activated receptor-γagonizts,glucokinases agonizts,mitochondrial energy modulators,etc.are under active development.DPDs are proposed for patients to obtain more systematic clinical care requires a comprehensive diabetes care center focusing on panvascular diseases.This would leverage the advantages of a cross-disciplinary approach to achieve better integration of the pathogenesis and therapeutic evidence.Such a strategy would confer more clinical benefits to patients and promote the comprehensive development of DPD as a discipline.