Ten novel 1, 1-dimethyl-3-(2-or 5-aryl-4-acetyl-2, 3-dihydro-1, 3, 4-oxadiazoline-5-or- 2-yl)-1, 2, 5, 6- tetrahydropyridinium iodides were synthesized from starting material nicotinalde- hyde or nicotinic acid by two...Ten novel 1, 1-dimethyl-3-(2-or 5-aryl-4-acetyl-2, 3-dihydro-1, 3, 4-oxadiazoline-5-or- 2-yl)-1, 2, 5, 6- tetrahydropyridinium iodides were synthesized from starting material nicotinalde- hyde or nicotinic acid by two different synthetic methods respectively. The preliminary bioactive tests indicate som compounds exhibit potent relaxing effect on endothelial cells, comparable to Ach or arecoline.展开更多
基金Financial support of this work by the State Key Basic Rescarch and Development Project(No.G 199805112)
文摘Ten novel 1, 1-dimethyl-3-(2-or 5-aryl-4-acetyl-2, 3-dihydro-1, 3, 4-oxadiazoline-5-or- 2-yl)-1, 2, 5, 6- tetrahydropyridinium iodides were synthesized from starting material nicotinalde- hyde or nicotinic acid by two different synthetic methods respectively. The preliminary bioactive tests indicate som compounds exhibit potent relaxing effect on endothelial cells, comparable to Ach or arecoline.
