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Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression
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作者 Hongjia Zhang Xueqian Sun +19 位作者 Zhanming Li Tingting Liu Fang Zhang Xinyu Meng Kaimi Li Jianhua Xu Wei He Bo Jing Tong Wang Na Ni Beibei Sun Feng Yao Yadi Wu Qi Wang Jing Du Eugene Y.Chin Binhua P.Zhou Ping Jiang Lishun Wang Jiong Deng 《Genes & Diseases》 SCIE CSCD 2024年第3期144-147,共4页
Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate ... Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate by acetaldehyde dehydrogenase type 2(ALDH2).ALDH2 deficiency can lead to ACE accumulation and DNA damage. 展开更多
关键词 MORTALITY DAMAGE ALDH2
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Association of common polymorphisms in the LRP6 gene with sporadic coronary artery disease in a Chinese population 被引量:6
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作者 Wang Hui Liu Qi-ji +5 位作者 Chen Min-zhi Li Li Zhang Kai Cheng Guang-hui Ma Long Gong Yao-qin 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第3期444-449,共6页
Background Genetic factors contribute to the development of coronary artery disease (CAD).Recently,a missense mutation in the low density lipoprotein receptor related protein 6 (LRP6) gene,encoding low density lip... Background Genetic factors contribute to the development of coronary artery disease (CAD).Recently,a missense mutation in the low density lipoprotein receptor related protein 6 (LRP6) gene,encoding low density lipoprotein receptor related protein 6,has been implicated in an autosomal dominant form of early-onset CAD.The aim of this study was to determine whether the common variants in LRP6 are associated with sporadic CAD in Chinese.Methods A total of 766 CAD patients and 806 healthy controls were included in this study.The presence of angiographic CAD was determined by coronary angiographic analysis.Six signal nucleotide polymorphisms (SNPs) were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.Results A significant association was detected between rs11054731 in LRP6 intron 2 and CAD in our cohort (P=0.001).The CC genotype and C allele frequency in the case group were 52% and 72%.Using a dominant model of inheritance,the C allele of rs11054731 was shown to be an independent risk factor for CAD with an OR of 1.45 (95% CI:1.19-1.77,P=0.0002).With the stratification according to the number of affected coronary arteries,an association was observed between rs11054731 and CAD (P=0.0002).No significant association was observed between any other SNPs and the risk of CAD.Conclusion The C allele of the rs11054731 within the LRP6 gene was associated with increased risk and extent of CAD in Chinese. 展开更多
关键词 coronary artery disease low density lipoprotein receptor related protein 6 single nucleotide polymorphism
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Pulmonary sequestration with its feeding vessel originating from the proximal right coronary artery
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作者 Wang Mouyue 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第9期1797-1797,共1页
To the editor: Pulmnonary sequestration is an uncommon congenital anomaly in which the arterial supply derives most frequently from the thoracic or abdominal aorta and other origins of blood supply are rarely descri... To the editor: Pulmnonary sequestration is an uncommon congenital anomaly in which the arterial supply derives most frequently from the thoracic or abdominal aorta and other origins of blood supply are rarely described. Here we report a patient with the blood supply of pulmonary sequestration originating from right coronary artery (RCA). 展开更多
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