In present study, 37 subjects with local nodules greater than 4mm ( unilateral or bilateral) were selected from 1134 vasectomizcd men, and 42 subjects with small nodules (less than 4ram) were served as controls.
Toxicological studies on an adhesive blocking agent for vas deferens were carried out.It could be excreted from the body soon after some of the agent had been absorbed. No long-term accumulation phenomenon and no obvi...Toxicological studies on an adhesive blocking agent for vas deferens were carried out.It could be excreted from the body soon after some of the agent had been absorbed. No long-term accumulation phenomenon and no obvious effect of acute toxicity on rodent animals have been observed. The parameters of physiology, blood cells and blood biochemistry were not affected apparently. The histomorphological study showed that the blocked part of vas deferens was obliterated with fibrous tissue and sperm deposition was found in the blocked end toward epididymis. The agent had no carcinogenic effect. Moreover, on the basis of mutation assay with Salmonella typhimarium strains, analysis of chromosome aberration, mieronuclei assay in bone marrow cells of mouse and domirrant lethal mutation assay, it was shown that the agent had no mutagenic effect.展开更多
文摘In present study, 37 subjects with local nodules greater than 4mm ( unilateral or bilateral) were selected from 1134 vasectomizcd men, and 42 subjects with small nodules (less than 4ram) were served as controls.
文摘Toxicological studies on an adhesive blocking agent for vas deferens were carried out.It could be excreted from the body soon after some of the agent had been absorbed. No long-term accumulation phenomenon and no obvious effect of acute toxicity on rodent animals have been observed. The parameters of physiology, blood cells and blood biochemistry were not affected apparently. The histomorphological study showed that the blocked part of vas deferens was obliterated with fibrous tissue and sperm deposition was found in the blocked end toward epididymis. The agent had no carcinogenic effect. Moreover, on the basis of mutation assay with Salmonella typhimarium strains, analysis of chromosome aberration, mieronuclei assay in bone marrow cells of mouse and domirrant lethal mutation assay, it was shown that the agent had no mutagenic effect.
