Influencing factors of anxiety in isolated population under COVID-19 and clinical observation of acupuncture intervention

Objective To investigate the anxiety of isolated people under the epidemic of 2019-novel coronavirus infection,analyze its related factors,and evaluate the clinical efficacy of acupuncture intervention in isolated people with acute anxiety Methods From March 31,2022 to September 9,2022.

Study on mechanism of Shenqu Zhuyu decoction in improving varicocele rats spermatogenesis based on PINK1/Parkin mediated mitophagy and apoptosis

Objective To observe the effect of the Shenqu Zhuyu Decoction(SZD)on varicocele(VC)rats mitophagy and apoptosis in left testis based on PTENinduced putative kinase 1(PINK1)/E3 ubiquitin protein ligase(Parkin)signaling pathway,and to explore its mechanism.Methods Totally 36 male SD rats were randomly divided into sham operation group,model group and SZD group,12 rats in each group.VC rats model was established by partial ligation of the left renal vein in model group and SZD group.At 48th day after successful molding,the rats in SZD group were treated with SZD(0.7 g/100 g)by gavage,and rats in sham operation group and model group were given the equal volume of normal saline by gavage,twice a day for 60 days.

Miao medicinal crossbow acupuncture therapy as adjuvant treatment for lung cancer pain:a randomized controlled trial

Objective To observe the clinical efficacy of Miao medicinal crossbow acupuncture therapy as adjuvant treatment for lung cancer pain based on oxycodone hydrochloride extended-release tablet.Methods A total of 60 patients with lung cancer pain were randomized into an observation group(30 cases,1 case dropped off)and a control group(30 cases).

Effect of Tongdu Tiaoshen electroacupuncture pretreatment on PPARγ-mediated pyroptosis of cerebral cortex in rats with cerebral ischemia reperfusion injury

Objective To observe the effect of Tongdu Tiaoshen(promoting the circulation of the governor vessel and regulating the spirit)electroacupuncture(EA)pretreatment on pyroptosis mediated by peroxisome proliferators-activated receptor γ(PPARγ)of the cerebral cortex in rats with cerebral ischemia reperfusion injury(CIRI)and explore the potential mechanism of EA for the prevention and treatment of CIRI.

Effects of Wenhua Juanbi decoction on proliferation,apoptosis and Hotair/Wnt1/β-catenin pathway in the synovial membrane of collagen-induced arthritis mice

Objective Taking collagen-induced arthritis(CIA)mice as experimental subjects,in vivo experiments were conducted to analyze the therapeutic mechanism of Wenhua Juanbi Decoction(WHJBD)in preventing and treating rheumatoid arthritis(RA)from the perspective of Hotair/Wnt1/β-catenin signaling pathway.

Effect of moxibustion on colonic low-grade inflammatory response in rats with diarrhea-predominant irritable bowel syndrome based on mast cell degranulation

Objective To observe the effects of moxibustion on colonic mast cell degranulation and inflammatory factor expression in rats with diarrhea-predominant irritable bowel syndrome(IBS-D),and explore the potential mechanism of moxibustion in treating IBS-D.Methods In forty-five rat pups born from 5 healthy SPF-grade pregnant SD rats,8 rats were randomly selected as normal group,and the remaining 37 rats were intervened with maternal separation,acetic acid enema,and chronic restraint stress to establish the IBS-D model.The successfully modeled 32 rats were then randomly assigned to a model group,a ketotifen group,a moxibustion group,and a moxibustion-medication group,with 8 rats in each group.The rats in the ketotifen group were intervened with intragastric administration of ketotifen solution(10 mL/kg).

Correlation between serum KIM-1,NGAL and diabetic kidney disease remission after gastric bypass surgery in obese patiens

Objective To investigate the correlation between serum renal injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in the remission of diabetic kidney disease (DKD) after gastric bypass surgery in obese DKD patients.Methods Seventy-nine obese patients with DKD who received gastric bypass surgery in our hospital from January 2021 to January 2022 were selected and divided into DKD remission group (n=47) and DKD non-remission group (n=32)according to whether UACR decreased to normal level after surgery.Preoperative and postoperative general data were collected and biochemical indices.

Effect of electroacupuncture on the bio-chemical indices of bone and bone collagen metabo-lism and TNF-α in osteoporosis model rats without ovaries

Objective To explore the mechanisms of electroacu-puncture(EA) on postmenopausal osteoporosis(PMO).Methods Sixty female SD rats aged 6 months were selected,resected double ovaries and fed for 90 days in order to make the model of experimental osteoporosis,and then,they were randomly divided into a model control

Clinical value of myositis antibodies in patients with connective tissue disease-associated interstitial lung diseases

Objective To investigate the clinical significance of detection of myositis-specific antibodies(MSAs)and myositis-associated antibodies(MAAs)in patients with connective tissue disease-associated interstitial lung diseases(CTD-ILD).Methods Serum samples of 120 patients with CTD-ILD admitted to the Department of Respiratory,Affiliated Drum Tower Hospital of Nanjing University Medical College from December 2016 to April 2018 were collected for analysis.The patients included 45 with polymyositis/dermatomyositis(PM/DM),36 with Sjogren s syndrome(SS)and 39 with undifferentiated connective tissue disease(UCTD).There were 37 males and 83 females with an average age of(56±11)years.Thirty-two patients with non-CTD-ILD,10 males and 22 females with an average age of(42±17)years,were enrolled as the control group.Euroline Autoimmune Inflammatory Myopathies 16 Ag kit was used for detecting MSAs and MAAs,and the positive rates of serum MSAs and MAAs were calculated.

Clinicopathologic features of intestinal natural killer/T-cell lymphoma

Objective To study the clinicopathologic features,diagnosis and differential diagnosis of intestinal natural killer(NK)/T-cell lymphoma.Methods The clinical features,histopathology。

Effects of electroacupuncture at different time during reperfusion on the expression of Bcl-2and Beclin1 in myocardial tissue in rats with myocardial ischemia reperfusion injury

Objective To compare the effects of electroacupuncture (EA) at different time during reperfusion on the expression of autophagy-related protein Bel-2 and Beclinl in myocardial tissue in rats with myocardial ischemia reperfusion injury ( MIRI), and to explore the autophagy-related mechanism of EA on protecting MIRI.

Pulmonary extranodal natural killer/T-cell lymphoma: clinical analysis of three cases

Objective To improve the understanding of pulmonary involvement of extranodal natural killer/T-cell lymphoma(ENKTL)by analyzing the clinical manifestations,imaging and pathological features of this disease.Methods Three cases of ENKTL,proven by pathological diagnosis in Fuzhou General Clinical Medical College of Fujian Medical University,were retrospectively analyzed.Results All of the 3 cases were males,aged 74,61 and 49 years,respectively.The main clinical symptoms included cold and fever.One patient had nasal congestion and runny nose.Chest CT showed multiple lung nodules(n=3),masses(n=2)and patchy shadows(n=2),with irregular lesions and clear boundaries.The 3 cases had been misdiagnosed as community acquired pneumonia,and treated with intravenous injection of moxifloxacin.ENKTL was confirmed by CT-guided percutaneous biopsy with immunohistochemical staining,which showed that 3 cases were positive for CD56,CD2,in situ hybridization for EBV encoded RNA(EBER),while negative for CD20,and 2 cases were positive for CD3,Granzyme B;and 1 case was positive for T-cell intracytoplasmic antigen-1.All 3 patients received chemotherapy,but 2 patients died,one of rejection 1 month later after bone marrow transplantation.One patient had improved after chemotherapy with follow-up.Conclusion ENKTL should be considered when patients presented with fever,multiple lung nodules or consolidations which were non-responsive to antibiotics.Lung biopsy was the key to diagnosis.

Acupuncture combined with medication for blood-stasis in unstable angina patients with different thrombolysis in myocardial infarction risk stratification

Objective To observe the intervention effects of acupuncture combined with standardized treatment of western medicine on blood-stasis syndrome in unstable angina(UA)patients with different thrombolysis in myocardial infarction(TIMI)risk stratification.Methods According to TIMI risk score,a total of 72 UA patients were included,24 cases in low-risk(0 to 2 points)group,24

Effect of"Zhibian"(BL 54)-to-"Shuidao"(ST 28)needle insertion on the expression of Fas/FADD/Caspase-8 of death receptor pathway in rats with primary ovarian insufficiency

Objective To explore the effect of"Zhibian"(BL54)-to-"Shuidao"(ST 28)needle insertion on the ovarian function in the rats with primary ovarian insufficiency(POI)and the potential effect mechanism based on the Fas/FADD/Caspase-8 of death receptor pathway.

Yunpi Xiefei Huatan decoction alleviates airway inflammation and mucus hypersecretion in young asthmatic rats via inhibiting PI3K/AKT/NF-κB signaling pathway

Objective To explore the effect of Yunpi Xiefei Huatan Decoction(YXHD)on airway inflammation and mucus hypersecretion in young asthmatic rats based on the correlation of interleukin(IL)-23/T helper cell(Th17)inflammation axis and phosphatidylinositol 3kinase(PI3K)/protein kinase B(AKT)/nuclear factor kappa-B(NF-κB)signal axis.Methods Fifty-six young SD rats were randomly divided into 7 groups:normal group,model group,low-dose group of YXHD(LTCM)。

Effect of Kuanxiong aerosol for coronary microcirculation in patients with acute myocardial infarction after percutaneous coronary intervention

Objective To observe the effect of Kuanxiong Aerosol for coronary microcirculation in acute myocardial infarction(AMI)patients who received percutaneous coronary intervention(PCI)therapy.Methods Totally 63 AMI patients who received PCI were randomly assigned to experimental group(32 cases)and control group(31 cases).

Association of serum GSK-3β,BDNF,blood glucose fluctuation with mild cognitive impairment in elderly type 2 diabetic patients

Objective To investigate the association between serum glycogen synthase kinase 3β(GSK-3β),brainderived neurotrophic factor(BDNF),blood glucose fluctuation and mild cognitive impairment(MCI)in elderly patients with type 2 diabetes mellitus(T2DM).Methods 121 elderly T2DM patients who were hospitalized in the endocrinology department of Xuzhou Medical University Affiliated Hospital from May 2021 to January 2022 were selected and divided into cognitive normal group(T2DM,n=68)and MCI group(n=53)based on the scores of Montreal Cognitive Assessment Scale(MoCA)and Minimal Mental State Assessment Scale(MMSE).

Effect of moxibustion on immune function homeostasis in rats with diarrhea irritable bowel syndrome based on SCF/c-kit signaling pathway

Objective To observe the effects of moxibustion on the stem cell factor(SCF)/tyrosine kinase receptor(ckit)signaling pathway and immune function in rats with diarrhea irritable bowel syndrome(IBS-D),and to explore the mechanism of moxibustion for IBS-D.

Effects of staged acupuncture on endometrial receptivity and anxiety in patients with recurrent implantation failure of thin endometrium based on "thoroughfare vessel is the sea of blood" theory

Objective To compare the clinical efficacy between staged acupuncture based on“thoroughfare vessel is the sea of blood”theory combined with routine hormone replacement cycle treatment and routine hormone replacement cycle treatment for patients with recurrent implantation failure(RIF).

Correlation between visceral fat area and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus

Objective To explore the correlation between visceral fat area(VFA)and diabetic peripheral neuropathy(DPN)in patients with type 2 diabetes mellitus(T2DM).Methods 863 T2DM patients hospitalized in Linyi People’s Hospital from August 2020to April 2022 were selected and divided into simple T2DM group(n=497)and T2DM combined with DPN group(DPN,n=366).The general data and biochemical indexes of the two groups were compared.