Overexpression of tuftelin and KLF-5 and its clinicopathological features in hepatitis B virusrelated hepatocellular carcinoma

Objective To analyze and evaluate the expressions and clinical value of tuftelin (TUFT1) and Krüppel-like factor 5 (KLF5) in hepatitis B virus (HBV)-related hepatocellular carcinoma(HCC) tissues.Methods KLF5mRNA and TUFT1 mRNA transcriptional status in cancer and non-cancer groups were compared according to the Cancer Genome Atlas(TCGA) database.The differences and prognostic value between the groups were analyzed.

Clinical features of 19 patients with SIL-TAL1-positive T-cell acute lymphoblastic leukemia

Objective To assess the clinical characteristics and prognosis of patients with SIL-TAL1-positive T-cell acute lymphoblastic leukemia(T-ALL).Methods The clinical data of 19 SIL-TAL1-positive T-ALL patients admitted to the First Affiliated Hospital of Soochow University between January 2014 and February 2022 were retrospectively computed and contrasted with SIL-TAL1-negative T-ALL patients.Results The median age of the19 SIL-TAL1-positive T-ALL patients was 15(7 to41 years),including 16 males(84.2%).SIL-TAL1-positive T-ALL patients had younger age,higher WBC,and hemoglobin compared with SIL-TAL1-negative TALL patients.There was no discrepancy in gender distribution,PLT,chromosome abnormality distribution,immunophenotyping,and complete remission(CR)rate.The 3-year overall survival(OS) was 60.9% and74.4%,respectively(HR=2.070,P=0.071).The3-year relapse-free survival(RFS) was 49.2% and70.6%,respectively(HR=2.275,P=0.040).

Analysis on missed diagnosis or misdiagnosis of anomalous origin of left coronary artery from pulmonary artery by echocardiography from one single medical center

Objective To analyze the reasons of missed diagnosis or misdiagnosis on anomalous origin of left coronary artery from pulmonary artery(ALCAPA)by echocardiography.Methods This is a retrospective study.Patients with ALCAPA who underwent surgical treatment in Union Hospital,Tongji Medical College,Huazhong University of Science and Technology from August 2008 to December 2021 were included.

Metagenomic next-generation sequencing for the diagnosis of Pneumocystis jirovecii pneumonia after allogeneic hematopoietic stem cell transplantation

Objective To investigate the value of metagenomic next-generation sequencing (mNGS) in the diagnosis of Pneumocystis jirovecii pneumonia (PJP) in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods The data of 98patients with suspected pulmonary infection after alloHSCT who underwent pathogen detection from bronchoalveolar lavage fluid between June 2016 and August 2023 at Nanfang Hospital were analyzed.

Abnormal expression of circulating nuclear factor-κB in hepatocellular carcinoma and reversal of multidrug resistance through intervening its gene transcription

Objective To investigate the expressions of nuclear factor-κB(NF-κB) and P-glycoprotein(P-gp) in patients with liver diseases and the effects and mechanism of intervening NF-κB activation on multiple drug