Dear Editor,Hepatocellular carcinoma(HCC)ranks the fourth most lethal cancer worldwide and over 50%of cases are diagnosed as multifocal HCC(mHCC)with dismal prognosis.1 mHCC displays more complicated intratumor hetero...Dear Editor,Hepatocellular carcinoma(HCC)ranks the fourth most lethal cancer worldwide and over 50%of cases are diagnosed as multifocal HCC(mHCC)with dismal prognosis.1 mHCC displays more complicated intratumor heterogeneity(ITH)and clonal evolution course which decreases the efficacy of clinical treatments.展开更多
基金This work was supported by Guangdong Natural Science Funds for Distinguished Young Scholar(No.2015A030306001)the National Natural Science Foundation of China(Nos.81672407,81872001,81801895,82172579 and 82172646)Shenzhen Science and Technology Program(No.RCBS20221008093310022).The funding sources had no role in writing,data collection,analysis,interpretation,or any aspect pertinent to the study。
文摘Dear Editor,Hepatocellular carcinoma(HCC)ranks the fourth most lethal cancer worldwide and over 50%of cases are diagnosed as multifocal HCC(mHCC)with dismal prognosis.1 mHCC displays more complicated intratumor heterogeneity(ITH)and clonal evolution course which decreases the efficacy of clinical treatments.
