NQO1 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia

Objective： To investigate the relationship between NAD（P）H：quinone oxidoreductase 1 （NQOI） C609T polymorphism and colon cancer risk in farmers from western region of Inner Mongolia. Methods： Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was performed to analyze NQO1 C609T polymorphism from 160 healthy controls and 76 colon cancer patients. Results： Among the colon cancer patients, the incidence of NQOI T allele （53.29%） was significantly higher than it in control group （33.75%, P〈0.001）. The individuals with NQO1 T allele had higher risk [2.239 （95% CI： 1.510-3.321） times] to develop colon cancer than individuals with NQO1 C allele. The incidence of NQO1 （TFI-） （34.21%） in colon cancer patients was higher than that in control group （15.62%, P〈0.001）. Odds ratios （OR） analysis suggested that NQO1 （T/F） and NQOI （T/C） genotype carriers had 3.813 （95% CI： 1.836-7.920） times and 2.080 （1.026-4.219） times risk compared with wild-type NQO1 （C/C） gene carriers in developing colon cancer. Individuals with NQO1 （T/I＇） genotype had 2.541 （95% CI： 0.990-6.552） times, 3.713 （95% CI： 1.542-8.935） times, and 3.471 （95% CI： 1.356-8.886） times risk than individuals with NQOI （T/C） or NQOI （C/C） genotype in well- differentiated, moderately-differentiated, and poorly-differentiated colon cancer patients, respectively. Conclusions： NQO1 gene C609T could be one of risk factors of colon cancer in farmers from western region of Inner Mongolia,

Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese

BACKGROUND Hypertension(HTN)and type 2 diabetes mellitus(T2DM)are often coincident,and each condition is considered a risk factor for the other.Both occur frequently in the Inner Mongolia region of China.The reasons for differences in risk between Han and Mongolian ethnic groups are not known.The LEPR gene and its polymorphism,rs1137101(Gln223Arg),are both considered risk factors for HTN and T2DM,but any role of rs1137101 in the occurrence of HTN+T2DM remains unclear for Mongolian and Han populations in the Inner Mongolia region.AIM To investigate the relationship between rs1137101 and the occurrence of HTN with T2DM in Mongolian and Han populations in Inner Mongolia METHODS A total of 2652 subjects of Han and Mongolian ethnic origins were enrolled in the current study,including 908 healthy controls,1061 HTN patients and 683 HTN patients with T2DM.RESULTS The association between the rs1137101 polymorphism and HTN with T2DM was analyzed,and differences between Han and Mongolian individuals assessed.There was a significant correlation between rs1137101 and HTN(co-dominant,dominant,over-dominant and log-additive models)and HTN+T2DM(co-dominant,dominant,over-dominant and log-additive models)after adjustment for sex and age in individuals of Mongolian origin.rs1137101 was significantly associated with HTN(co-dominant,recessive and log-additive models)and HTN+T2DM(codominant,dominant,over-dominant and log-additive models)in the Han Chinese population.CONCLUSION Mongolian and Han subjects from Inner Mongolia with HTN who had rs1137101 were protected against the development of T2DM.Allele A has the opposite impact on the occurrence of HTN in Mongolian and Han Chinese populations.