Autophagy is an intracellular catabolic system in which cytoplasmic proteins or organelles are translocated into lysosomes for degradation.Three different types of autophagy have been identified as macroautophagy,micr...Autophagy is an intracellular catabolic system in which cytoplasmic proteins or organelles are translocated into lysosomes for degradation.Three different types of autophagy have been identified as macroautophagy,microautophagy,and chaperone-mediated autophagy(CMA).In macroautophagy,double-membraned phagophore develops autophagosome vesicles,which subsequently fuse with lysosomes to展开更多
Parkinson＇s disease （PD） is the second most common neurodegenerative disorder affecting more than 1% of the older population. Histopathologically, PD is characterized by a severe loss of dopaminergic neurons in the...Parkinson＇s disease （PD） is the second most common neurodegenerative disorder affecting more than 1% of the older population. Histopathologically, PD is characterized by a severe loss of dopaminergic neurons in the substantia nigra and cytoplasmic inclusions composed of insoluble protein aggregates （Lewy bodies）, which lead to a pro- gressive movement disorder including the classic triad of tremor, bradykinesia, and rigidity.展开更多
基金supported by the National Natural Science Foundation of China(81430021,81771521)the Program for Liaoning Innovative Research Team in University(LT2015009)+1 种基金the Scientific Research Fund of Liaoning Provincial Education Department(L2015145)the Liaoning Science and Technology Project(2015225008)
文摘Autophagy is an intracellular catabolic system in which cytoplasmic proteins or organelles are translocated into lysosomes for degradation.Three different types of autophagy have been identified as macroautophagy,microautophagy,and chaperone-mediated autophagy(CMA).In macroautophagy,double-membraned phagophore develops autophagosome vesicles,which subsequently fuse with lysosomes to
基金supported by the National Natural Science Foundation of China (81430021 and 81370470)
文摘Parkinson＇s disease （PD） is the second most common neurodegenerative disorder affecting more than 1% of the older population. Histopathologically, PD is characterized by a severe loss of dopaminergic neurons in the substantia nigra and cytoplasmic inclusions composed of insoluble protein aggregates （Lewy bodies）, which lead to a pro- gressive movement disorder including the classic triad of tremor, bradykinesia, and rigidity.
