Mechanical stimuli play critical roles in cardiovascular diseases,in which in vivo stresses in blood vessels present a great challenge to predict.Based on the structural-thermal coupled finite element method,we propos...Mechanical stimuli play critical roles in cardiovascular diseases,in which in vivo stresses in blood vessels present a great challenge to predict.Based on the structural-thermal coupled finite element method,we propose a thermal expansion method to estimate stresses in multi-layer blood vessels under healthy and pathological conditions.The proposed method provides a relatively simple and convenient means to predict reliable in vivo mechanical stresses with accurate residual stress.The method is first verified with the opening-up process and the pressure-radius responses for single and multi-layer vessel models.It is then applied to study the stress variation in a human carotid artery at different hypertension stages and in a plaque of vascular stenosis.Our results show that specific or optimal residual stresses exist for different blood pressures,which helps form a homogeneous stress distribution across vessel walls.High elastic shear stress is identified on the shoulder of the plaque,which contributes to the tearing effect in plaque rupture.The present study indicates that the proposed numerical method is a capable and efficient in vivo stress evaluation of patient-specific blood vessels for clinical purposes.展开更多
In recent years, the extraction of fossil resources, especially oil and gas in deep and ultra-deep water areas has been playing a more important role and been paid more attention to. For this reason, the working depth...In recent years, the extraction of fossil resources, especially oil and gas in deep and ultra-deep water areas has been playing a more important role and been paid more attention to. For this reason, the working depth of submarine pipelines, which are used for the transportation of oil and gas, has been increasing sharply. As the main failure pattern of deep-water pipelines, buckling and its propagation problem have drawn more attention of many research institutions and engineering units around the world. Based on the existing research, the summary of experiments and their outcomes of deep-water pipeline buckling failure is made in this paper. Research status and developing prospects of the experiments of buckling propagation and buckle arrestor are discussed in detail.展开更多
基金The authors would like to thank Prof.Shu Takagi and Prof.Huaxiong Huang for their instructive comments.The authors would also like to acknowledge Jianda Yang for assisting with FEM simulations.This work was supported by the National Natural Science Foundation of China(Grants 11372191,11232010,11650(Grant 91111138)the National Institute of Health(Grant 2R01DC005642-10A1).
文摘Mechanical stimuli play critical roles in cardiovascular diseases,in which in vivo stresses in blood vessels present a great challenge to predict.Based on the structural-thermal coupled finite element method,we propose a thermal expansion method to estimate stresses in multi-layer blood vessels under healthy and pathological conditions.The proposed method provides a relatively simple and convenient means to predict reliable in vivo mechanical stresses with accurate residual stress.The method is first verified with the opening-up process and the pressure-radius responses for single and multi-layer vessel models.It is then applied to study the stress variation in a human carotid artery at different hypertension stages and in a plaque of vascular stenosis.Our results show that specific or optimal residual stresses exist for different blood pressures,which helps form a homogeneous stress distribution across vessel walls.High elastic shear stress is identified on the shoulder of the plaque,which contributes to the tearing effect in plaque rupture.The present study indicates that the proposed numerical method is a capable and efficient in vivo stress evaluation of patient-specific blood vessels for clinical purposes.
基金Supported by the National Natural Science Foundation of China(No.51239008)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.51321065)the National Basic Research Program of China(“973”Program,No.2014CB046805)
文摘In recent years, the extraction of fossil resources, especially oil and gas in deep and ultra-deep water areas has been playing a more important role and been paid more attention to. For this reason, the working depth of submarine pipelines, which are used for the transportation of oil and gas, has been increasing sharply. As the main failure pattern of deep-water pipelines, buckling and its propagation problem have drawn more attention of many research institutions and engineering units around the world. Based on the existing research, the summary of experiments and their outcomes of deep-water pipeline buckling failure is made in this paper. Research status and developing prospects of the experiments of buckling propagation and buckle arrestor are discussed in detail.
