Objective: To explore the possible mechanisms of "JIN San Zhen" (JIN’s 3 acupoints groups) in treatment of mental retardation. Methods: A total of 38 female mice were randomly divided into normal control (n...Objective: To explore the possible mechanisms of "JIN San Zhen" (JIN’s 3 acupoints groups) in treatment of mental retardation. Methods: A total of 38 female mice were randomly divided into normal control (n=10), sham operation (n=10), model (n=8) and acupuncture (n=10) groups. "Si Shen Zhen" [4 points around "Baihui" (GV 20): 0.3 cm anterior, posterior, left and right to GV 20 respectively], and "Zhi San Zhen" ["Shenting" (GV 24) and bilateral "Benshen" (GB 13)] of "JIN San Zhen" series are used. The memory ability, AChE positive fiber density and mono amines transmitters of the brain are used as the indexes. Results: After 8 days’ treatment, cerebral ischemia induced mental retardation (decline of learning memory ability) was improved significantly shown by Y maze test (P<0.05-0.01), simultaneously, AChE positive fiber density of the frontal cerebral cortex and hippocampus, serotonie (5 HT), noradrenaline (NA) and dopamine (DA) contents of the brain increased significantly (P<0.05). Conclusion: Acupuncture induced increase of AChE, 5 HT, NA and DA in the brain may contribute to the effect of acupuncture in improving the memory capability of the RD mice.展开更多
文摘Objective: To explore the possible mechanisms of "JIN San Zhen" (JIN’s 3 acupoints groups) in treatment of mental retardation. Methods: A total of 38 female mice were randomly divided into normal control (n=10), sham operation (n=10), model (n=8) and acupuncture (n=10) groups. "Si Shen Zhen" [4 points around "Baihui" (GV 20): 0.3 cm anterior, posterior, left and right to GV 20 respectively], and "Zhi San Zhen" ["Shenting" (GV 24) and bilateral "Benshen" (GB 13)] of "JIN San Zhen" series are used. The memory ability, AChE positive fiber density and mono amines transmitters of the brain are used as the indexes. Results: After 8 days’ treatment, cerebral ischemia induced mental retardation (decline of learning memory ability) was improved significantly shown by Y maze test (P<0.05-0.01), simultaneously, AChE positive fiber density of the frontal cerebral cortex and hippocampus, serotonie (5 HT), noradrenaline (NA) and dopamine (DA) contents of the brain increased significantly (P<0.05). Conclusion: Acupuncture induced increase of AChE, 5 HT, NA and DA in the brain may contribute to the effect of acupuncture in improving the memory capability of the RD mice.
