期刊文献+
共找到8篇文章
< 1 >
每页显示 20 50 100
Optimization of a Multi-node System Reliability Model
1
作者 魏展明 周凡 陈耀武 《Journal of Donghua University(English Edition)》 EI CAS 2011年第5期451-455,共5页
In order to improve the reliability of an electronic or a computer system, redundant components always need to be added as part of the system. When an active component falls, a standby component will be activated to g... In order to improve the reliability of an electronic or a computer system, redundant components always need to be added as part of the system. When an active component falls, a standby component will be activated to guarantee the system in operation continuously. The standby component and the switching device have been usually assumed to be continuously functional duriv,g the setup of the reliability model. In fact, it is these two asstuxtptions that induce deviations during modeling and introduce variances for the system reliability design. Through modeling and optiming the dependability of the synchronous clock system that decomposed from a multi-node system, a new reliability model which takes these two elements into consideration has been developed. Simulation results demonstrate that the upgraded reliability model is closer Io the actual dependability of the real system. The capability of the system reliability design is also improved as a result. 展开更多
关键词 RELIABILITY REDUNDANCY hot-spare cold standby SWITCH
下载PDF
内源性和外源性NO对大鼠动脉压力感受器反射的调节(英文) 被引量:1
2
作者 宁钢民 杨晓玲 +1 位作者 李海燕 郑筱祥 《航天医学与医学工程》 CAS CSCD 北大核心 2004年第6期391-396,共6页
目的研究内源性和外源性一氧化氮 (NO)对动脉压力感受器反射的不同作用。方法静脉注射苯肾上腺素 (PE ,30 μg·kg- 1 ) ,改变大鼠血压 ,诱发动脉压力感受器反射。分别静脉注射硝普钠 (SNP ,1 0 .2 μg·kg- 1 )和L 精氨酸 (L A... 目的研究内源性和外源性一氧化氮 (NO)对动脉压力感受器反射的不同作用。方法静脉注射苯肾上腺素 (PE ,30 μg·kg- 1 ) ,改变大鼠血压 ,诱发动脉压力感受器反射。分别静脉注射硝普钠 (SNP ,1 0 .2 μg·kg- 1 )和L 精氨酸 (L Arg ,2 5mg·kg- 1 )以产生外源性和内源性NO ,静脉注射L NAME( 1 0mg·kg- 1 )抑制内源性NO的产生 ,并估测NO的产生或抑制对压力感受器敏感性的影响。结果与正常状态比较 ,L Arg使大鼠压力感受器反射敏感性 (Gmax)和血压 -心率拟合曲线斜率τ显著下降 [Gmax=- 1 .469± 0 .1 2 0beats/(min·mmHg)vs. - 0 .664± 0 .0 80beats/(min·mmHg) ,P <0 .0 1 ;τ =0 .0 86±0 .0 0 5vs .0 .0 4 9± 0 .0 0 7,P <0 .0 5 ]。SNP尽管也引起了上述参数的减小 ,但作用不显著。与L Arg和SNP的作用相反 ,L NAME导致了Gmax和τ的上升 ,但变化不显著。结论内源性和外源性NO对压力感受器反射的作用不同 ,内源性NO可能抑制压力感受器反射的敏感性。 展开更多
关键词 一氧化氮 自主神经系统 动脉 压力反射 敏感性 一氧化氮合酶
下载PDF
A Lower and Upper Bound Method for Complex System Reliability Evaluation 被引量:1
3
作者 魏展明 周凡 陈耀武 《Journal of Donghua University(English Edition)》 EI CAS 2011年第5期445-450,共6页
It is hard for the existing methods to obtain the expression of the system reliability for most of the practical complex systems with a large number of components and possible stales. A new regression algorithm based ... It is hard for the existing methods to obtain the expression of the system reliability for most of the practical complex systems with a large number of components and possible stales. A new regression algorithm based on the lower and upper bounds is presented in this paper, which can obtain the system reliability analytically without concerning the structure of the complex system. The method has been applied to a real system and the reliability results are compared with those acquired by the classical method and the parametric method. The effectiveness and accuracy of the proposed method have been testified. 展开更多
关键词 RELIABILITY lower bound upper bound regression algorithm
下载PDF
Changes of paired-pulse evoked responses during the development of epileptic activity in the hippocampus 被引量:1
4
作者 Zhou-yan FENG Xiao-jing ZHENG Cong TIAN Yang WANG Hao-yu XING 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2011年第9期704-711,共8页
Dysfunction of inhibitory synaptic transmission can destroy the balance between excitatory and inhibitory synaptic inputs in neurons,thereby inducing epileptic activity.The aim of the paper is to investigate the effec... Dysfunction of inhibitory synaptic transmission can destroy the balance between excitatory and inhibitory synaptic inputs in neurons,thereby inducing epileptic activity.The aim of the paper is to investigate the effects of successive excitatory inputs on the epileptic activity induced in the absence of inhibitions.Paired-pulse orthodromic and antidromic stimulations were used to test the changes in the evoked responses in the hippocampus.Picrotoxin(PTX),γ-aminobutyric acid(GABA) type A(GABA A) receptor antagonist,was added to block the inhibitory synaptic transmission and to establish the epileptic model.Extracellular evoked population spike(PS) was recorded in the CA1 region of the hippocampus.The results showed that the application of PTX induced a biphasic change in the paired-pulse ratio of PS amplitude.A short latency increase of the second PS(PS2) was later followed by a reappearance of PS2 depression.This type of depression was observed in both orthodromic and antidromic paired-pulse responses,whereas the GABAergic PS2 depression [called paired-pulse depression(PPD)] during baseline recordings only appeared in orthodromic-evoked responses.In addition,the depression duration at approximately 100 ms was consistent with a relative silent period observed within spontaneous burst discharges induced by prolonged application of PTX.In conclusion,the neurons may ignore the excitatory inputs and intrinsically generate bursts during epileptic activity.The depolarization block could be the mechanisms underlying the PPD in the absence of GABA A inhibitions.The distinct neuronal responses to stimulations during different epileptic stages may implicate the different antiepileptic effects of electrical stimulation. 展开更多
关键词 EPILEPSY Paired-pulse depression γ-Aminobutyric acid(GABA) Picrotoxin(PTX) CA1 region In-vivo
原文传递
A mini-review and perspective on ferroptosis-inducing strategies in cancer therapy 被引量:3
5
作者 Shuaifei Wang Hongwei Liao +1 位作者 Fangyuan Li Daishun Ling 《Chinese Chemical Letters》 SCIE CAS CSCD 2019年第4期847-852,共6页
Ferroptosis, as a new type of cell death caused by lipid peroxidation, has attracted much attention since it was first identified in 2012. A lot of progress has been made in unraveling its mechanisms and therapeutic p... Ferroptosis, as a new type of cell death caused by lipid peroxidation, has attracted much attention since it was first identified in 2012. A lot of progress has been made in unraveling its mechanisms and therapeutic potential as a target for cancer therapy. Hitherto, there are mainly two strategies widely adopted for designing ferroptosis-inducing agents, which include increasing the intracellular reactive oxygen species(ROS) level by Fenton reaction, and inactivating the glutathione peroxidase 4(GPX4). In this mini-review,we summarize the recent advances in ferroptosis-based anticancer treatments with a highlight on nanomaterials, and discuss the current challenges faced by those agents from the perspective of in vivo applications. Moreover, by generalizing ferroptosis induced by excess iron ions to cell death caused by the polyvalent metal-mediated oxidative burden, we introduce a new paradigm of cancer treatment by exploiting various polyvalent metals to disrupt the vulnerable redox balance in cancer cells, which may greatly diversify our arsenal to combat cancer. 展开更多
关键词 Ferroptosis Fenton reaction Reactive oxygen species LIPID PEROXIDATION GLUTATHIONE PEROXIDASE 4
原文传递
Controlled Cell Patterning on Bioactive Surfaces with Special Wettability 被引量:1
6
作者 Xiaofeng Zhou Jiaqian Li +3 位作者 Hongyan Sun Yi Hu Lufeng Che Zuankai Wang 《Journal of Bionic Engineering》 SCIE EI CSCD 2017年第3期440-447,共8页
The ability to control cell patterning on artificial substrates with various physicochemical properties is of essence for important implications in cytology and biomedical fields. Despite extensive progress, the abili... The ability to control cell patterning on artificial substrates with various physicochemical properties is of essence for important implications in cytology and biomedical fields. Despite extensive progress, the ability to control the cell-surface interaction is complicated by the complexity in the physiochemical features of bioactive surfaces. In particular, the manifesta- tion of special wettability rendered by the combination of surface roughness and surface chemistry further enriches the cell-surface interaction. Herein we investigated the cell adhesion behaviors of Circulating Tumor Cells (CTCs) on topog- raphically patterned but chemically homogeneous surfaces. Harnessing the distinctive cell adhesion on surfaces with different topography, we further explored the feasibility of controlled cell patterning using periodic lattices of alternative topographies. We envision that our method provides a designer's toolbox to manage the extracellular environment. 展开更多
关键词 cell patterning WETTABILITY SUPERHYDROPHILIC surface chemistry circulating tumor cells
原文传递
Progress in defining heterogeneity and modeling periglomerular cells in the olfactory bulb
7
作者 YING Nan TIAN Jian +4 位作者 YU SaiNan ZHOU Jing LING ShuCai XIA Ling YE XueSong 《Science China(Life Sciences)》 SCIE CAS 2012年第7期567-575,共9页
In recent years the evolution of olfactory bulb periglomerular cells,as well as the function of periglomerular cells in olfactory encoding,has attracted increasing attention.Studies of neural information encoding base... In recent years the evolution of olfactory bulb periglomerular cells,as well as the function of periglomerular cells in olfactory encoding,has attracted increasing attention.Studies of neural information encoding based on the analysis of simulation and modeling have given rise to electrophysiological models of periglomerular cells,which have an important role in the understanding of the biology of these cells.In this review we provide a brief introduction to the anatomy of the olfactory system and the cell types in the olfactory bulb.We elaborate on the latest progress in the study of the heterogeneity of periglomerular cells based on different classification criteria,such as molecular markers,structure,ion channels and action potentials.Then,we discuss the several existing electrophysiological models of periglomerular cells,and we highlight the problems and defects of these models.Finally,considering our present work,we propose a future direction for electrophysiological investigations of periglomerular cells and for the modeling of periglomerular cells and olfactory information encoding. 展开更多
关键词 periglomerular cell PATCH-CLAMP modeling and simulation HETEROGENEITY
原文传递
Inter-satellite range-finding method with high precision and large range based on optoelectronic resonance
8
作者 陈斌 于晋龙 +4 位作者 王菊 李天宇 王文睿 于洋 谢田元 《Chinese Optics Letters》 SCIE EI CAS CSCD 2016年第11期43-47,共5页
As microsatellite technology develops,precise inter-satellite measurement shows its significance in distributed satellite systems.In this Letter,a novel technique is proposed for measuring the inter-satellite distance... As microsatellite technology develops,precise inter-satellite measurement shows its significance in distributed satellite systems.In this Letter,a novel technique is proposed for measuring the inter-satellite distance,which adopts optoelectronic resonance and has a function of self-referencing.Resonance cavities have a high spectral purity and a high oscillation frequency.By utilizing the accumulative amplification principle to convert the measurement of distance to that of the frequency,high accuracy is achieved.In the experiment,this measuring scheme has a large measuring range between 1 and 6 km(can be potentially larger),and the accuracy is better than 1.5 urn.The relative accuracy reaches the level of 10^-10. 展开更多
关键词 Range finding RESONANCE
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部