Capsaicin exerts anti-benign prostatic hyperplasia effects via inhibiting androgen receptor signaling pathway

Background:Benign prostatic hyperplasia(BPH)is a common condition in middle-aged and elderly men.Enlargement of the prostate causes lower urinary tract symptoms.Capsaicin is a phytochemical extracted from chili peppers and exerts many pharmacological actions,such as anti-tumor and anti-inflammatory effects.Methods:Our study investigated the effect of capsaicin in vitro and in a mouse model in vivo.A prostatic stromal myofibroblast cell line(WPMY-1)was co-incubated with testosterone(1µM)and different concentrations of capsaicin(10–100µM)for 24 and 48 h.Capsaicin(10–100µM)significantly inhibited testosterone-treated WPMY-1 cell growth at 48 h by MTT assay.The testosterone propionate(7.5 mg/kg)-induced BPH mouse model was used to examine the anti-proliferative effect of capsaicin.Treatment with capsaicin(10 mg/kg)for 14 days significantly attenuated prostatic hyperplasia.Finasteride was used as a positive control.Results:Capsaicin significantly decreased prostate weight and prostate index(prostate/body weight ratio)in BPH mice.The expression of 5α-reductase type II,androgen receptor(AR)and prostate specific antigen(PSA)protein expression and PSA serum were all significantly reduced in capsaicin-treated BPH mice.In addition,capsaicin also activated transient receptor potential vanilloid 1 mediated apoptosis and autophagy in BPH mice.Conclusion:These results demonstrate multiple positive effects of capsaicin in controlling prostate growth and suggest its therapeutic potential in the treatment of BPH.

Study on the Flocculability of Metal Ions by Bacillus Mucilaginosus GY03 Strain

这研究处理金属离子 byBacillus mucilaginosus GY03 紧张的二种类型的 flocculability ，与 pH 条件的影响上的一个重音， GY03 生产的凝聚剂的体积和时间在象Pb2+和Mn2+和凝聚剂的能力那样的金属熨斗的吸附上拉紧吸附不同集中的金属离子。结果证明微生物引起的凝聚剂生产了 byBacillus mucilaginosus GY03 紧张高度能够絮凝金属离子，而是表演关于 Pb2+ 和 Mn2+ 的吸附的不同有效性。根据试验性的数据和实际废水处理条件，絮凝的相关回归方程被推出了，它在实践发现了一些申请。这研究的试验性的结果证明微生物引起的凝聚剂生产了 byBacillus mucilaginosus 能被用来对待金属性的包含离子的浪费水。在实际申请，微生物引起的凝聚剂的体积要求了，絮凝条件应该根据金属离子，阴离子的作文和另外的金属的溶解度的性质被拿进全面考虑，在有要过去常的凝聚剂的费用和有效性的联合。在这个实验使用的凝聚剂有的优点在絮凝的大量 pH 值，小凝聚剂卷，和快速的速度上被使用。这种凝聚剂因此在申请的优秀前景以内。关键词微生物引起的凝聚剂 - 杆菌 mucilaginosus - 硅酸盐细菌 - flocculability - 废水处理这个研究工程被州的关键实验室财政上联合支持。中国科学院(HDH010901 ) 和中国的环境地球化学基础博士后的科学基础(2003033496 ) 。

Review on Mutation in Lateral Root of Rice

Rice roots include seminal roots, adventitious roots, lateral roots and root hairs, At present, progresses in the research of rice roots have been achieved in many aspects, such as root morphology, root activity, root reaction to various environmental factors as a contribution of root growth and rice yield, the relationship between root growth and stems/leaves/flowers/rice, genetic laws of root characters, etc. However, there are very few researches on lateral root mutant. This paper reviewed progresses of the lateral root mutant of rice from the perspectives of phytomorphology to plant physiology and biochemistry to the gene mapping, consisting of mechanism of developing lateral root of rice, gene cloning and functional analysis of lateral root development, the relationship between auxin and lateral roots, agronomic traits of lateral roots mutant, structure and morphology of root hairs, gravity anomaly of root, redox metabolism and proteomics researches of the mutation in lateral root of rice.

Systematic pharmacology analysis of Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate

The purpose of this study is to use the newly synthesized molecule Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate(M)as a research object,the pharmacological mechanism of the molecule was analyzed by using a series of Systematic pharmacology methods.The results show that the M molecule has a higher drug-like DL value of 0.59 and better molecular property parameters,namely Hdon=4,Hacc=10 and AlogP=0.94;A total of 11 M molecules related targets,namely F2,ESR1,AR,F10,CA2,DPP4,CCNA2,PRSS1,CDK2,GSK3B and PTPN1;A total of 140 diseases are associated with M molecule targets,and these diseases are mainly related to cancer and cardiovascular diseases;A total of 52 pathways involve the pharmacological mechanisms of M molecules,which are mainly related to cancer and other related diseases;GO-enriched analysis showed that these targets are closely related to the regulation of peptidase activity and biological processes such as blood coagulation and hemostasis.This article clearly demonstrated the pharmacological mechanism of M molecule,which provides references for exploring the pharmacological mechanism of new compounds.

Synthesis of Enaminone-Pd(Ⅱ)Complexes and Their Application in Catalysing Aqueous Suzuki-Miyaura Cross Coupling Reaction

A series of Pd(Ⅱ)-enaminone complexes,termed Pd(eao)2,have been synthesized and characterized.The investigation on the catalytic activities of these new Pd(Ⅱ)-reagents has proved that the Pd(ea0)2-1 possesses excellent catalytic activity for the Suzuki-Miyaura cross coupling reactions of aryl bromides/chlorides with ary/vinyl boronic acids in the environmentally benign media of aqueous PEG400 at low loading(5 mol‰).The superiority of this Pd(Ⅱ)-reagent to those commercial Pd(Ⅱ)and Pd(0)catalysts in catalyzing the reactions has been confirmed by parallel experiments.What's more,Pd(eao)2-2 has been found as a practical catalyst for the homo-coupling reactions of aryl boronic acids.

ROS is essential for initiation of energy deprivation-induced autophagy

Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear.