This study was carried out to find out if alligator pepper can prevent the development of fetal macrosomia in Sprague-Dawley rats fed with high glycemic index diet. Fifteen adult female Sprague-Dawley rats of proven f...This study was carried out to find out if alligator pepper can prevent the development of fetal macrosomia in Sprague-Dawley rats fed with high glycemic index diet. Fifteen adult female Sprague-Dawley rats of proven fertility were acclimatized for a period of two weeks in a well-ventilated laboratory and fed with grower’s mash and water ad libitum. Thereafter, they were randomly placed in separate cages after which a male Sprague-Dawley rat of proven fertility was introduced into each of the cages containing the female rats. They were left in the cages for three days during, which mating was confirmed to have occurred. The male rats were then withdrawn from the female rats, which were placed in separate maternity cages. The female rats were randomly allocated to three groups A, B and C so there were 5 pregnant rats in each group. The rats in group A were fed with 50 g of grower’s mash daily while the rats in groups B and C were fed with 50 g of cooked fermented cassava respectively. All rats were given water ad libitum throughout the duration of the experiment. The rats in groups A and B were intraperitoneally injected with 13.3 ml per Kg body weight of distilled water while the rats in group C were intraperitoneally injected with 13.3 mg/Kg body weight of aqueous extract of alligator pepper respectively. They were observed for 18 - 25 days. The litters of the rats in group B had a significantly higher mean weight than the rats in group A while the litters of the rats in group C had a significantly lower mean weight than the rats in groups B. It was concluded that intraperitoneally injected aqueous extract of alligator pepper, in the first trimester of pregnancy, can prevent the development of fetal macrosomia in Sprague-Dawley rats.展开更多
Several studies have shown that sickle cell disease (SCD) is made worse by infections;it was necessary to carry out this study to ascertain the occurrence of intestinal parasitic infections to the number of SCD patien...Several studies have shown that sickle cell disease (SCD) is made worse by infections;it was necessary to carry out this study to ascertain the occurrence of intestinal parasitic infections to the number of SCD patients infected compared to Non-SCD patients, the impact of the infections on Pack cell volume (PCV) of the SCD patients in Nigeria populace. A total of 140 stool samples were collected from both SCD patients and Non-SCD patients. 3 ml of venous blood, seventy samples in total were collected from the SCD patients only. The blood and stool samples were collected from September 2005 to November 2005;structured questionnaire was administered to each of the patient that gave consent to be part of the study alongside with questionnaire interview. The stool samples were analysed macroscopically and microscopically using saline, iodine and formal-ether concentration technique. The blood samples were analysed by micro-heamatocrit method. The findings showed that a total of six parasites were identified among the SCD patients and a total of thirteen parasites were identified among Non-SCD patients. Although the prevalence of intestinal parasitic infections was low among the research participates, the identified parasites fell into the 4 major categories of intestinal parasites, an indication that SCD patients can be susceptible to any of the intestinal worms/protozoa. Despite a low prevalence of intestinal parasites among the studied individual at the time of this study, it is however, necessary for regular laboratory investigations for intestinal worm/protozoa since they are still a public health problem.展开更多
Air emissions during palm oil processing by smallholders are issues of public health concern demanding urgent intervention by environmentalist. In this study, six smallholder oil palm processing mills were studied inE...Air emissions during palm oil processing by smallholders are issues of public health concern demanding urgent intervention by environmentalist. In this study, six smallholder oil palm processing mills were studied inElele,Nigeria. Air emission parameters (NO2, NH3, CO, H2S, SO2, VOC), noise and meteorology (wind speed, temperature, relative humidity and pressure) were determined at three distances (10 ft,25 ftand50 ft) in both wind ward and lee ward directions from the mills covering boiling and digestion activities. The emissions from biomass were found to be significantly higher than that from fossil diesel, while noise was higher during digestion. The health implications of air emissions were discussed. The study concluded by directing attentions of regulatory agencies to monitor the activities of smallholder oil palm processing to ensure the environmental sustainability of their operations. In summary, evidence during boiling activity revealed that: · H2S ranged from - 2.400 ppm at10 ft, - 2.067 ppm at25 ftand - 0.833 ppm at50 ftfrom the mills in the wind ward direction, and - 1.167 ppm at10 ft, - 0.567 ppm at25 ftand - 0.367 ppm at50ftdistance from the mills in lee ward direction and was significantly lower during digestion. · SPM ranged from 1634 - 7853 μg/m3 at10 ft, 657 - 1110 μg/m3 at25 ftand 81 - 854 μg/m3 at50 ftfrom the mills in the wind ward direction, and 46 - 236 μg/m3 at10 ft, 44 - 120 μg/m3 at25 ftand 30 - 58 μg/m3 at50 ftfrom the mills in lee ward direction. SPM was significantly lower during digestion. · VOC ranged from 67 - 13.933 ppm at10 ft, 1.033 - 13.133 ppm at25ftand 0.500 -展开更多
Introduction: Cervical cancer remains a major cause of morbidity and mortality among the female population in sub-Saharan Africa. Vaccination against human papillomavirus (HPV), the main causative agent, has the poten...Introduction: Cervical cancer remains a major cause of morbidity and mortality among the female population in sub-Saharan Africa. Vaccination against human papillomavirus (HPV), the main causative agent, has the potential to eradicate cervical cancer. In-country evidence of sub-types of HPV associated with cervical cancer is scanty, thus necessitating this study. Methods: A cross-sectional study was performed using a multistage sampling technique. A molecular technique using the Cobas 4800 machine was used for genotyping. Results: 570 participants were recruited for the study. The mean age of the participants was 32.4 ± 5.2 years. The age of sexual debut ranged from 15 - 24 years with a median of 19 years. 194 participants were positive for high-risk HPV giving a prevalence of 34%. 3% (n = 17) were positive for HPV, 16. 4% (23) had a positive result for HPV, 18. 27% (n = 154) had a positive result for other high-risk groups (OHR) other than HPV 16 or 18. Positive status for high-risk HPV is associated with the presence of genital warts (OR = 7.5), a Positive HIV status (OR = 3.48), abnormal vaginal discharge (OR = 2.20), multiple sexual partners (OR = 2.30), and obesity (OR = 2.70). The prevalence of HIV in the study population was 6.84% (n = 39). Conclusion: Another High-risk HPV other than 16 and 18 appears to be the predominant form of HPV infection in Nigerian women. The risk of being positive for high-risk HPV is associated with the presence of genital warts, abnormal vaginal discharge, a positive HIV status, multiple sexual partners and Obesity. It is therefore necessary to disaggregate and study these high-risk sub-types.展开更多
文摘This study was carried out to find out if alligator pepper can prevent the development of fetal macrosomia in Sprague-Dawley rats fed with high glycemic index diet. Fifteen adult female Sprague-Dawley rats of proven fertility were acclimatized for a period of two weeks in a well-ventilated laboratory and fed with grower’s mash and water ad libitum. Thereafter, they were randomly placed in separate cages after which a male Sprague-Dawley rat of proven fertility was introduced into each of the cages containing the female rats. They were left in the cages for three days during, which mating was confirmed to have occurred. The male rats were then withdrawn from the female rats, which were placed in separate maternity cages. The female rats were randomly allocated to three groups A, B and C so there were 5 pregnant rats in each group. The rats in group A were fed with 50 g of grower’s mash daily while the rats in groups B and C were fed with 50 g of cooked fermented cassava respectively. All rats were given water ad libitum throughout the duration of the experiment. The rats in groups A and B were intraperitoneally injected with 13.3 ml per Kg body weight of distilled water while the rats in group C were intraperitoneally injected with 13.3 mg/Kg body weight of aqueous extract of alligator pepper respectively. They were observed for 18 - 25 days. The litters of the rats in group B had a significantly higher mean weight than the rats in group A while the litters of the rats in group C had a significantly lower mean weight than the rats in groups B. It was concluded that intraperitoneally injected aqueous extract of alligator pepper, in the first trimester of pregnancy, can prevent the development of fetal macrosomia in Sprague-Dawley rats.
文摘Several studies have shown that sickle cell disease (SCD) is made worse by infections;it was necessary to carry out this study to ascertain the occurrence of intestinal parasitic infections to the number of SCD patients infected compared to Non-SCD patients, the impact of the infections on Pack cell volume (PCV) of the SCD patients in Nigeria populace. A total of 140 stool samples were collected from both SCD patients and Non-SCD patients. 3 ml of venous blood, seventy samples in total were collected from the SCD patients only. The blood and stool samples were collected from September 2005 to November 2005;structured questionnaire was administered to each of the patient that gave consent to be part of the study alongside with questionnaire interview. The stool samples were analysed macroscopically and microscopically using saline, iodine and formal-ether concentration technique. The blood samples were analysed by micro-heamatocrit method. The findings showed that a total of six parasites were identified among the SCD patients and a total of thirteen parasites were identified among Non-SCD patients. Although the prevalence of intestinal parasitic infections was low among the research participates, the identified parasites fell into the 4 major categories of intestinal parasites, an indication that SCD patients can be susceptible to any of the intestinal worms/protozoa. Despite a low prevalence of intestinal parasites among the studied individual at the time of this study, it is however, necessary for regular laboratory investigations for intestinal worm/protozoa since they are still a public health problem.
文摘Air emissions during palm oil processing by smallholders are issues of public health concern demanding urgent intervention by environmentalist. In this study, six smallholder oil palm processing mills were studied inElele,Nigeria. Air emission parameters (NO2, NH3, CO, H2S, SO2, VOC), noise and meteorology (wind speed, temperature, relative humidity and pressure) were determined at three distances (10 ft,25 ftand50 ft) in both wind ward and lee ward directions from the mills covering boiling and digestion activities. The emissions from biomass were found to be significantly higher than that from fossil diesel, while noise was higher during digestion. The health implications of air emissions were discussed. The study concluded by directing attentions of regulatory agencies to monitor the activities of smallholder oil palm processing to ensure the environmental sustainability of their operations. In summary, evidence during boiling activity revealed that: · H2S ranged from - 2.400 ppm at10 ft, - 2.067 ppm at25 ftand - 0.833 ppm at50 ftfrom the mills in the wind ward direction, and - 1.167 ppm at10 ft, - 0.567 ppm at25 ftand - 0.367 ppm at50ftdistance from the mills in lee ward direction and was significantly lower during digestion. · SPM ranged from 1634 - 7853 μg/m3 at10 ft, 657 - 1110 μg/m3 at25 ftand 81 - 854 μg/m3 at50 ftfrom the mills in the wind ward direction, and 46 - 236 μg/m3 at10 ft, 44 - 120 μg/m3 at25 ftand 30 - 58 μg/m3 at50 ftfrom the mills in lee ward direction. SPM was significantly lower during digestion. · VOC ranged from 67 - 13.933 ppm at10 ft, 1.033 - 13.133 ppm at25ftand 0.500 -
文摘Introduction: Cervical cancer remains a major cause of morbidity and mortality among the female population in sub-Saharan Africa. Vaccination against human papillomavirus (HPV), the main causative agent, has the potential to eradicate cervical cancer. In-country evidence of sub-types of HPV associated with cervical cancer is scanty, thus necessitating this study. Methods: A cross-sectional study was performed using a multistage sampling technique. A molecular technique using the Cobas 4800 machine was used for genotyping. Results: 570 participants were recruited for the study. The mean age of the participants was 32.4 ± 5.2 years. The age of sexual debut ranged from 15 - 24 years with a median of 19 years. 194 participants were positive for high-risk HPV giving a prevalence of 34%. 3% (n = 17) were positive for HPV, 16. 4% (23) had a positive result for HPV, 18. 27% (n = 154) had a positive result for other high-risk groups (OHR) other than HPV 16 or 18. Positive status for high-risk HPV is associated with the presence of genital warts (OR = 7.5), a Positive HIV status (OR = 3.48), abnormal vaginal discharge (OR = 2.20), multiple sexual partners (OR = 2.30), and obesity (OR = 2.70). The prevalence of HIV in the study population was 6.84% (n = 39). Conclusion: Another High-risk HPV other than 16 and 18 appears to be the predominant form of HPV infection in Nigerian women. The risk of being positive for high-risk HPV is associated with the presence of genital warts, abnormal vaginal discharge, a positive HIV status, multiple sexual partners and Obesity. It is therefore necessary to disaggregate and study these high-risk sub-types.
