The efficacy and safety of NeuroWell antidepressant dietary supplement,Deanxit,and their combination in the treatment of mild-to-moderate depression:A randomized clinical trial

Depression is the leading global cause of,disability,affecting about 300 milion people worldwide.1;2 Depending on the number and severity of symptoms,depressive episodes can be classified as mild,moderate,and severe.Previous studies have typically focused on the treatment of severe refractory depression,while there have been few studies on the treatment of mild-to-moderate depression.

Corticospinal activity during a single-leg stance in people with chronic ankle instability

Purpose:The aim of the study was to determine whether corticospinal excitability and inhibition of the tibialis anterior during single-leg standing differs among individuals with chronic ankle instability(CAI),lateral ankle sprain copers,and healthy controls.Methods:Twenty-three participants with CAI,23 lateral ankle sprain copers,and 24 healthy control participants volunteered.Active motor threshold(AMT),normalized motor-evoked potential(MEP),and cortical silent period(CSP)were evaluated by transcranial magnetic stimulation while participants performed a single-leg standing task.Results:Participants with CAI had significantly longer CSP at 100%of AMT and lower normalized MEP at 120%of AMT compared to lateral ankle sprain copers(CSP100%:p=0.003;MEP120%:p=0.044)and controls(CSP100%:p=0.041;MEP120%:p=0.006).Conclusion:This investigation demonstrate altered corticospinal excitability and inhibition of the tibialis anterior during single-leg standing in participants with CAI.Further research is needed to examine the effects of corticospinal maladaptations to motor control of the tibial anterior on postural control performance in those with CAI.

Low-Load Bench Press Training to Fatigue Results in Muscle Hypertrophy Similar to High-Load Bench Press Training

The purpose of this study was to determine whether the training responses observed with low-load resistance exercise to volitional fatigue translates into significant muscle hypertrophy, and compare that response to high-load resistance training. Nine previously untrained men (aged 25 [SD 3] years at the beginning of the study, standing height 1.73 [SD 0.07] m, body mass 68.9 [SD 8.1] kg) completed 6-week of high load-resistance training (HL-RT) (75% of one repeti-tion maximal [1RM], 3-sets, 3x/wk) followed by 12 months of detraining. Following this, subjects completed 6 weeks of low load-resistance training (LL-RT) to volitional fatigue (30% 1 RM, 4 sets, 3x/wk). Increases (p 0.05) in magnetic resonance imaging-measured triceps brachii and pectorals major muscle cross-sectional areas were similar for both HL-RT (11.9% and 17.6%, respectively) and LL-RT (9.8% and 21.1%, respectively). In addition, both groups increased (p 0.05) 1RM and maximal elbow extension strength following training;however, the percent increases in 1RM (8.6% vs. 21.0%) and elbow extension strength (6.5% vs. 13.9%) were significantly (p 0.05) lower with LL-RT. Both protocols elicited similar increases in muscle cross-sectional area, however differences were observed in strength. An explanation of the smaller relative increases in strength may be due to the fact that detraining after HL-RT did not cause strength values to return to baseline levels thereby producing smaller changes in strength. In addition, the results may also suggest that the consistent practice of lifting a heavy load is necessary to maximize gains in muscular strength of the trained movement. These results demonstrate that significant muscle hypertrophy can occur without high-load resistance training and suggests that the focus on percentage of external load as the important deciding factor on muscle hypertrophy is too simplistic and inappropriate.

Effects of silent myocardial ischemia on functional fitness and physical independence in 60–79-year-old adults

Objective:We examined the effect of silent myocardial ischemia(SMI)on functional fitness levels and physical independence in 60–79-year-old individuals.Methods:We conducted a cross-sectional study with 716 older adults and used an electrocardiograph and an ambulatory electrocardiogram to diagnose those with SMI.Physical independence was assessed using the Composite Physical Function scale,whereas physical fitness was assessed using the Senior Fitness Test battery.Results:The 60-79-year-old females and males with SMI were more likely to have lower scores for lower and upper body strength,agility/dynamic balance,and aerobic endurance(p<0.05)than those without SMI.The scores for lower and upper body flexibility in all age groups for both genders were not significant(p>0.05).Binary logistic regression analysis revealed that old adults with SMI had a higher risk of losing physical independence later in life than those without SMI(p<0.05).Conclusion:This study showed that individuals with SMI have lower fitness levels and increased risk of losing physical independence than those without SMI.