期刊文献+
共找到185,207篇文章
< 1 2 250 >
每页显示 20 50 100
Investigation on the Knowledge, Attitude and Practice of Oral Health among Medical College and University Undergraduate
1
作者 Xiuying Guan Dongming Li +4 位作者 Deping Zou Xin Yu Shuyin Pan Zheng Yang Jianzhong Huang 《Health》 2024年第7期602-614,共13页
Objectives: This study aims to investigate the status of knowledge, attitude and practice (KAP) of oral health among medical undergraduate students, and provide reference for implementing oral health interventions. Me... Objectives: This study aims to investigate the status of knowledge, attitude and practice (KAP) of oral health among medical undergraduate students, and provide reference for implementing oral health interventions. Methods: A total of 528 undergraduate students enrolled in Fuzhou Medical College from February 2023 to September 2023 were selected as the research subjects. Their oral health KAP were investigated, and the oral health behavior habits of different types of medical students were compared, and possible influencing factors were analyzed. Results: The total awareness rate of oral health knowledge among medical students is 77.0%, with an average score of 3.85 ± 1.16 points. The overall positive rate of oral health attitudes among medical students is 80.0%, with an average score of 3.19 ± 0.72 points. The total qualified rate of oral health behavior is 65.9%, with an average score of 4.61 ± 1.23 points. The scores of oral health knowledge, attitudes, and behaviors among medical students are related to gender, major, smoking status, and oral health status. The frequency of brushing teeth in the female group was higher than that in the male group, while the habit of brushing teeth before bedtime and the frequency of timely replacement of toothbrushes when deformed were lower, with statistical significance (p 0.05). The frequency of timely replacement of toothbrushes varies among medical students from different majors, and the difference is statistically significant (p 0.05). People who have a habit of eating hot and cold food have a higher frequency of brushing their teeth every day, and the difference is statistically significant (p 0.05). Non smokers have a better habit of brushing their teeth before bedtime and a higher frequency of timely replacement when their toothbrush deforms, with a statistically significant difference (p 0.05). The frequency of using fluoride toothpaste or medicated toothpaste, having a habit of unilateral chewing, and timely replacement of toothbrushes when deformed in patients with existing oral problems is higher than that of those without oral problems, and the difference is statistically significant (p 0.05). Conclusion: The knowledge, attitude, and behavior of oral health among medical students in this school are above average. Students with different genders, dietary and smoking habits, and oral health status have different oral health behavioral habits. It is recommended to include oral health education in mandatory courses for various medical majors. 展开更多
关键词 Medical Students Oral Health Knowledge Attitude Practice Correlation Analysis
下载PDF
Establishment and Exploration of Functional Party Groups in Science and Technology Institutes under the Academy System:A Case Study of Runze College of Ningxia University
2
作者 Yue ZHOU 《Meteorological and Environmental Research》 2024年第5期17-20,共4页
The education and management of college student Party members is the focus of student Party building work in colleges and universities.In the context of students second classroom being conducted in the academy,the man... The education and management of college student Party members is the focus of student Party building work in colleges and universities.In the context of students second classroom being conducted in the academy,the management of student Party members should enhance their Party spirit cultivation through improving their self-management and self-monitoring.After the comprehensive reform of Ningxia University,Runze College targeted the characteristics of agricultural majors and set up functional Party groups to enable student Party members to play a pioneering and exemplary role in the second classroom.Runze College relies on the academy system and breaks through the traditional one-way management mode led by Party branch teachers in the second classroom of college students.It leverages the role of functional Party groups in off campus science and technology academies,and integrates Party building work into daily teaching and research and solving agricultural production technology problems for local villagers,achieving the goal of promoting and integrating Party building and business work,and improving each other. 展开更多
关键词 Academy system Science and technology academy Functional Party group Establishment and exploration
下载PDF
Innovation and Practice of the Cultivation Mode of Application-Oriented Undergraduate Talents in Agricultural and Forestry Colleges under the Guidance of the Spirit of the Great Northern Wilderness
3
作者 Dawei Yin Xiaohong Guo +10 位作者 Hui Yang Wen Zheng Mingyu Fan Xiaodan Xu Qitao Li Xiuzhi Wang Hongyu Li Guiping Zheng Haize Wang Menghong Liu Yueyue Liu 《Open Journal of Applied Sciences》 2024年第8期2027-2038,共12页
Heilongjiang reclamation area has made great progress since its development and construction, among which the agricultural and forestry colleges in China have played a key role in the input of talents for the producti... Heilongjiang reclamation area has made great progress since its development and construction, among which the agricultural and forestry colleges in China have played a key role in the input of talents for the production of reclamation area, and the spirit of the Great Wilderness has important strategic significance for the cultivation of agricultural and forestry talents. Taking Heilongjiang Bayi Agricultural University as an example, this paper analyzes the ways of the Great Northern Wilderness Spirit for cultivating application-oriented undergraduate talents in agricultural and forestry colleges, improving the curriculum system of undergraduate talents through innovation, strengthening the cultivation of students’ innovative ability, leading students’ scientific research and academic level, and enhancing students’ practical ability. To innovate the cultivation mode of application-oriented undergraduate talents in agricultural and forestry colleges under the guidance of the spirit of the Great Northern Wilderness, and to provide a reference mode for the cultivation of undergraduate talents in agricultural and forestry colleges in China. 展开更多
关键词 Northern Wilderness Spirit Undergraduate Talents Research Application Cultivation Mode INNOVATION
下载PDF
Collaborative Cultivation of Ideological and Political Education and Undergraduate Management in Colleges and Universities Under the Guidance of Moral Education
4
作者 Jianyuan Xie 《Journal of Contemporary Educational Research》 2024年第4期221-225,共5页
Guided by moral education,improving the ideological and moral quality of college students is an important goal of college education.To achieve this goal,it is necessary to strengthen ideological and political educatio... Guided by moral education,improving the ideological and moral quality of college students is an important goal of college education.To achieve this goal,it is necessary to strengthen ideological and political education and continuously improve the level of undergraduate management.This paper outlines the feasibility of collaborative cultivation of ideological and political education and undergraduate management in colleges and universities and analyzes its significance and the specific implementation strategies,with a view to providing valuable references for relevant colleges and universities to carry out educational work. 展开更多
关键词 Moral education Colleges and universities Ideological and political education Undergraduate management
下载PDF
Exploration of the “Four-Three-Four” Internship and Training Mode in Higher Vocational Colleges Under the Modern Vocational Education System
5
作者 Jifeng Liu Na Han +2 位作者 Xiaojiao Li Jing Wang Xuezhen Feng 《Journal of Contemporary Educational Research》 2024年第3期111-117,共7页
This article mainly introduces the innovative internship and training model of vocational colleges,including five aspects such as“four-party collaboration,three-stage progression,four-way integration,value-added eval... This article mainly introduces the innovative internship and training model of vocational colleges,including five aspects such as“four-party collaboration,three-stage progression,four-way integration,value-added evaluation,and double selection and promotion.”The model aims to improve students’practical skills and professional quality to better adapt to market demand and social development.The article also presents the prospects of the future internship and training model,including strengthening cooperation and communication with industry enterprises,focusing on students’personalized development and practical skill cultivation,and establishing a scientific and objective evaluation and feedback mechanism. 展开更多
关键词 Four-party collaboration Three-stage progression Four-way integration Value-added evaluation Double selection and promotion
下载PDF
Research on Professional Teaching Reform of the E-Commerce Major in Vocational Colleges Under the Internet Era
6
作者 Yong Liang 《Journal of Contemporary Educational Research》 2024年第5期21-26,共6页
With the rapid development of science and technology,the face of human society has undergone great changes;with the emergence of the Internet era,all kinds of educational technology,equipment,and software in vocationa... With the rapid development of science and technology,the face of human society has undergone great changes;with the emergence of the Internet era,all kinds of educational technology,equipment,and software in vocational colleges have been widely used to carry out education and teaching,and has achieved remarkable results.Based on this,colleges and universities’electronic commerce(e-commerce)professional teachers should try to rely on the Internet to build information teaching classrooms,introduce advanced methods to build efficient classrooms by integrating teaching resources,and optimize the top-level design,so as to activate the classroom atmosphere,mobilize students’emotions,make them immersed in the teaching of electronic commerce courses.In view of this,this paper combines the existing theory and experience,first analyzes the dilemma faced by the current teaching of e-commerce in vocational colleges,then discusses the practical significance of teaching reform based on the Internet era,and lastly puts forward the specific practice path. 展开更多
关键词 INTERNET Vocational colleges E-commerce major Teaching reform
下载PDF
Reform Practice of College Students’ Employment Guidance Course under the Concept of Curriculum Ideology and Politics
7
作者 Lei Yan 《Journal of Contemporary Educational Research》 2024年第8期220-225,共6页
Under the background of“fostering character and civic virtue,”higher education must effectively integrate ideological and political education.The concept of curriculum ideology and politics has become increasingly d... Under the background of“fostering character and civic virtue,”higher education must effectively integrate ideological and political education.The concept of curriculum ideology and politics has become increasingly developed and sophisticated,which can be a guiding concept for the teaching and reform practice of college students’employment guidance courses.Based on educational observation and logical analysis,this paper elaborates on the connotation of the concept of curriculum ideology and politics,analyzes the key points of the reform of college students’employment guidance courses under this concept,and affirms the value of course reform.On this basis,this paper specifically analyzes the common problems in the reform of the employment guidance course under the new concept and makes a detailed interpretation of the performance problems such as the vague course objectives and the lack of innovation in the course teaching methods.Combined with the relevant problems,this paper proposes strategies such as building the course objective system by linking the curriculum ideology and politics,and driving the teaching innovation of the course from multiple perspectives,aiming to provide more references for the corresponding course reform. 展开更多
关键词 Curriculum ideology and politics Employment guidance Curriculum reform
下载PDF
Investigation of the Current Situation of Innovation Ability Education of Vocational College Students Under the Guidance of Ideological and Political Education
8
作者 Xiaolin Fan Nurjulidezi Baheti Yonghong Gu 《Journal of Contemporary Educational Research》 2024年第3期73-77,共5页
Innovation ability is the ability to continuously provide new ideas,theories,methods,and inventions with economic,social,and ecological values in the fields of technology and various practical activities.The ideologic... Innovation ability is the ability to continuously provide new ideas,theories,methods,and inventions with economic,social,and ecological values in the fields of technology and various practical activities.The ideological and political education of vocational school students should be student-oriented and close to reality and life.It is necessary to improve the pertinence,effectiveness,attractiveness,and infectiousness of ideological and political education,and cultivate socialist builders and successors with all-round development of morality,intelligence,physique,and beauty.In this paper,we investigate and understand the practice of innovation ability education in colleges and universities at home and abroad,especially the current situation of professional practice teaching in Xinjiang Vocational Colleges.The construction of a professional practice base in vocational colleges is systematically studied. 展开更多
关键词 Ideological and political education Innovation ability education Vocational college students
下载PDF
Research on the Reform of Assessment under the Blended Teaching Mode:Taking the Teaching Practice of English Stylistics in Guangdong Technology College as an Example
9
作者 Jie Zhang 《Journal of Contemporary Educational Research》 2024年第11期145-152,共8页
English Stylistics is provided as an elective course by the Business English major at Guangdong Technology College,whose evaluation mechanism significantly impacts how well students learn the language.A novel assessme... English Stylistics is provided as an elective course by the Business English major at Guangdong Technology College,whose evaluation mechanism significantly impacts how well students learn the language.A novel assessment model is put forth in this study with the intention of transforming from a single summative assessment to a combination of formative and summative assessment in light of the shortcomings of the current assessment methodology in the course.In order to take advantage of blended teaching and integrate the online and offline learning resources of English Stylistics,all-round reforms have been carried out at multiple levels,including teaching content,teaching methods,and assessment approaches.Therefore,a more reasonable and diversified assessment method has been adopted to more comprehensively reflect students’learning objectives and proficiency in foreign languages. 展开更多
关键词 Blended teaching Assessment method English Stylistics
下载PDF
Grain yield and N uptake of maize in response to increased plant density under reduced water and nitrogen supply conditions 被引量:4
10
作者 Jingui Wei Qiang Chai +5 位作者 Wen Yin Hong Fan Yao Guo Falong Hu Zhilong Fan QimingWang 《Journal of Integrative Agriculture》 SCIE CSCD 2024年第1期122-140,共19页
The development of modern agriculture requires the reduction of water and chemical N fertilizer inputs.Increasing the planting density can maintain higher yields,but also consumes more of these restrictive resources.H... The development of modern agriculture requires the reduction of water and chemical N fertilizer inputs.Increasing the planting density can maintain higher yields,but also consumes more of these restrictive resources.However,whether an increased maize density can compensate for the negative effects of reduced water and N supply on grain yield and N uptake in the arid irrigated areas remains unknown.This study is part of a long-term positioning trial that started in 2016.A split-split plot field experiment of maize was implemented in the arid irrigated area of northwestern China in 2020 to 2021.The treatments included two irrigation levels:local conventional irrigation reduced by 20%(W1,3,240 m^(3)ha^(-1))and local conventional irrigation(W2,4,050 m^(3)ha^(-1));two N application rates:local conventional N reduced by 25%(N1,270 kg ha^(-1))and local conventional N(360 kg ha^(-1));and three planting densities:local conventional density(D1,75,000 plants ha^(-1)),density increased by 30%(D2,97,500 plants ha-1),and density increased by 60%(D3,120,000 plants ha^(-1)).Our results showed that the grain yield and aboveground N accumulation of maize were lower under the reduced water and N inputs,but increasing the maize density by 30% can compensate for the reductions of grain yield and aboveground N accumulation caused by the reduced water and N supply.When water was reduced while the N application rate remained unchanged,increasing the planting density by 30% enhanced grain yield by 13.9% and aboveground N accumulation by 15.3%.Under reduced water and N inputs,increasing the maize density by 30% enhanced N uptake efficiency and N partial factor productivity,and it also compensated for the N harvest index and N metabolic related enzyme activities.Compared with W2N2D1,the N uptake efficiency and N partial factor productivity increased by 28.6 and 17.6%under W1N1D2.W1N2D2 had 8.4% higher N uptake efficiency and 13.9% higher N partial factor productivity than W2N2D1.W1N2D2 improved urease activity and nitrate reductase activity by 5.4% at the R2(blister)stage and 19.6% at the V6(6th leaf)stage,and increased net income and the benefit:cost ratio by 22.1 and 16.7%,respectively.W1N1D2 and W1N2D2 reduced the nitrate nitrogen and ammoniacal nitrogen contents at the R6 stage in the 40-100 cm soil layer,compared with W2N2D1.In summary,increasing the planting density by 30% can compensate for the loss of grain yield and aboveground N accumulation under reduced water and N inputs.Meanwhile,increasing the maize density by 30% improved grain yield and aboveground N accumulation when water was reduced by 20% while the N application rate remained constant in arid irrigation areas. 展开更多
关键词 water and N reduction plant density MAIZE grain yield N uptake compensation effect
下载PDF
Activation of the wnt/β-catenin/CYP1B1 pathway alleviates oxidative stress and protects the blood-brain barrier under cerebral ischemia/reperfusion conditions 被引量:9
11
作者 Xingyong Chen Nannan Yao +4 位作者 Yanguang Mao Dongyun Xiao Yiyi Huang Xu Zhang Yinzhou Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1541-1547,共7页
Accumulating evidence suggests that oxidative stress and the Wnt/β-catenin pathway participate in stroke-induced disruption of the blood-brain barrier.However,the potential links between them following ischemic strok... Accumulating evidence suggests that oxidative stress and the Wnt/β-catenin pathway participate in stroke-induced disruption of the blood-brain barrier.However,the potential links between them following ischemic stroke remain largely unknown.The present study found that cerebral ischemia leads to oxidative stress and repression of the Wnt/β-catenin pathway.Meanwhile,Wnt/β-catenin pathway activation by the pharmacological inhibito r,TWS119,relieved oxidative stress,increased the levels of cytochrome P4501B1(CYP1B1)and tight junction-associated proteins(zonula occludens-1[ZO-1],occludin and claudin-5),as well as brain microvascular density in cerebral ischemia rats.Moreove r,rat brain microvascular endothelial cells that underwent oxygen glucose deprivation/reoxygenation displayed intense oxidative stress,suppression of the Wnt/β-catenin pathway,aggravated cell apoptosis,downregulated CYP1B1and tight junction protein levels,and inhibited cell prolife ration and migration.Overexpression ofβ-catenin or knockdown ofβ-catenin and CYP1B1 genes in rat brain mic rovascular endothelial cells at least partly ameliorated or exacerbated these effects,respectively.In addition,small interfering RNA-mediatedβ-catenin silencing decreased CYP1B1 expression,whereas CYP1B1 knoc kdown did not change the levels of glycogen synthase kinase 3β,Wnt-3a,andβ-catenin proteins in rat brain microvascular endothelial cells after oxygen glucose deprivatio n/reoxygenation.Thus,the data suggest that CYP1B1 can be regulated by Wnt/β-catenin signaling,and activation of the Wnt/β-catenin/CYP1B1 pathway contributes to alleviation of oxidative stress,increased tight junction levels,and protection of the blood-brain barrier against ischemia/hypoxia-induced injury. 展开更多
关键词 blood-brain barrier CYP1B1 oxidative stress oxygen glucose deprivation/reoxygenation tight junction vascular endothelial cells Wnt/β-catenin pathway β-catenin
下载PDF
The underlying mechanism of variety–water–nitrogen–stubble damage interactions on yield formation in ratoon rice with low stubble height under mechanized harvesting 被引量:2
12
作者 Jingnan Zou Ziqin Pang +11 位作者 Zhou Li Chunlin Guo Hongmei Lin Zheng Li Hongfei Chen Jinwen Huang Ting Chen Hailong Xu Bin Qin Puleng Letuma Weiwei Lin Wenxiong Lin 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第3期806-823,共18页
Agronomic measures are the key to promote the sustainable development of ratoon rice by reducing the damage from mechanical crushing to the residual stubble of the main crop, thereby mitigating the impact on axillary ... Agronomic measures are the key to promote the sustainable development of ratoon rice by reducing the damage from mechanical crushing to the residual stubble of the main crop, thereby mitigating the impact on axillary bud sprouting and yield formation in ratoon rice. This study used widely recommended conventional rice Jiafuzhan and hybrid rice Yongyou 2640 as the test materials to conduct a four-factor block design field experiment in a greenhouse of the experimental farm of Fujian Agricultural and Forestry University, China from 2018 to 2019.The treatments included fertilization and no fertilization, alternate wetting and drying irrigation and continuous water flooding irrigation, and plots with and without artificial crushing damage on the rice stubble. At the same time, a 13C stable isotope in-situ detection technology was used to fertilize the pot experiment. The results showed significant interactions among varieties, water management, nitrogen application and stubble status.Relative to the long-term water flooding treatment, the treatment with sequential application of nitrogen fertilizer coupled with moderate field drought for root-vigor and tiller promotion before and after harvesting of the main crop, significantly improved the effective tillers from low position nodes. This in turn increased the effective panicles per plant and grains per panicle by reducing the influence of artificial crushing damage on rice stubble and achieving a high yield of the regenerated rice. Furthermore, the partitioning of 13C assimilates to the residual stubble and its axillary buds were significantly improved at the mature stage of the main crop, while the translocation rate to roots and rhizosphere soil was reduced at the later growth stage of ratooning season rice. This was triggered by the metabolism of hormones and polyamines at the stem base regulated by the interaction of water and fertilizer at this time. We therefore suggest that to achieve a high yield of ratoon rice with low stubble height under mechanized harvesting, the timely application of nitrogen fertilizer is fundamental,coupled with moderate field drying for root-vigor preservation and tiller promotion before and after the mechanical harvesting of the main crop. 展开更多
关键词 mechanized harvesting ratoon rice rice stubble yield attributes
下载PDF
Failure transition of shear-to-dilation band of rock salt under triaxial stresses 被引量:3
13
作者 Jianfeng Liu Xiaosong Qiu +3 位作者 Jianxiong Yang Chao Liang Jingjing Dai Yu Bian 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第1期56-64,共9页
Great potential of underground gas/energy storage in salt caverns seems to be a promising solution to support renewable energy.In the underground storage method,the operating cycle unfortunately may reach up to daily ... Great potential of underground gas/energy storage in salt caverns seems to be a promising solution to support renewable energy.In the underground storage method,the operating cycle unfortunately may reach up to daily or even hourly,which generates complicated pressures on the salt cavern.Furthermore,the mechanical behavior of rock salt may change and present distinct failure characteristics under different stress states,which affects the performance of salt cavern during the time period of full service.To reproduce a similar loading condition on the cavern surrounding rock mass,the cyclic triaxial loading/unloading tests are performed on the rock salt to explore the mechanical transition behavior and failure characteristics under different confinement.Experimental results show that the rock salt samples pre-sent a diffused shear failure band with significant bulges at certain locations in low confining pressure conditions(e.g.5 MPa,10 MPa and 15 MPa),which is closely related to crystal misorientation and grain boundary sliding.Under the elevated confinement(e.g.20 MPa,30 MPa and 40 MPa),the dilation band dominates the failure mechanism,where the large-size halite crystals are crushed to be smaller size and new pores are developing.The failure transition mechanism revealed in the paper provides additional insight into the mechanical performance of salt caverns influenced by complicated stress states. 展开更多
关键词 Rock salt Cyclic mechanical loading Shear band Dilation band Underground gas storage(UGS)
下载PDF
Effects of thinning on the understory light environment of different stands and the photosynthetic performance and growth of the reforestation species Phoebe bournei 被引量:2
14
作者 Shicheng Su Nianqing Jin Xiaoli Wei 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第1期12-28,共17页
Light levels determine regeneration in stands and a key concern is how to regulate the light environment of different stand types to the requirements of the understory.In this study,we selected three stands typical in... Light levels determine regeneration in stands and a key concern is how to regulate the light environment of different stand types to the requirements of the understory.In this study,we selected three stands typical in south China(a Cryptomeria japonica plantation,a Quercus acutissima plantation,and a mixed stand of both)and three thinning intensities to determine the best understory light environ-ment for 3-year-old Phoebe bournei seedlings.The canopy structure,understory light environment,and photosynthe-sis and growth indicators were assessed following thin-ning.Thinning improved canopy structure and understory light availability of each stand;species composition was the reason for differences in the understory light environ-ment.Under the same thinning intensity,the mixed stand had the greatest light radiation and most balanced spectral composition.P.bournei photosynthesis and growth were closely related to the light environment;all three stands required heavy thinning to create an effective and sustained understory light environment.In a suitable understory light environment,the efficiency of light interception,absorption,and use by seedlings was enhanced,resulting in a higher carbon assimilation the main limiting factor was stomatal conductance.As a shade-avoidance signal,red/far-red radia-tion is a critical factor driving changes in photosynthesis and growth of P.bournei seedlings,and a reduction increased light absorption and use capacity and height:diameter ratios.The growth advantage transformed from diameter to height,enabling seedlings to access more light.Our findings suggest that the regeneration of shade-tolerant species such as P.bournei could be enhanced if a targeted approach to thinning based on stand type was adopted. 展开更多
关键词 THINNING Understory light environment Phoebe bournei Photosynthetic performance Growth performance
下载PDF
Understanding the spectrum of non-motor symptoms in multiple sclerosis:insights from animal models 被引量:1
15
作者 Poornima D.E.Weerasinghe-Mudiyanselage Joong-Sun Kim +1 位作者 Taekyun Shin Changjong Moon 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期84-91,共8页
Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic,physically debilitating neurological disorder.In addition to experiencing motor disabi... Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic,physically debilitating neurological disorder.In addition to experiencing motor disability,patients with multiple sclerosis also experience a variety of nonmotor symptoms,including cognitive deficits,anxiety,depression,sensory impairments,and pain.However,the pathogenesis and treatment of such non-motor symptoms in multiple scle rosis are still under research.Preclinical studies for multiple sclerosis benefit from the use of disease-appropriate animal models,including experimental autoimmune encephalomyelitis.Prior to understanding the pathophysiology and developing treatments for non-motor symptoms,it is critical to chara cterize the animal model in terms of its ability to replicate certain non-motor features of multiple sclerosis.As such,no single animal model can mimic the entire spectrum of symptoms.This review focuses on the non-motor symptoms that have been investigated in animal models of multiple sclerosis as well as possible underlying mechanisms.Further,we highlighted gaps in the literature to explain the nonmotor aspects of multiple sclerosis in expe rimental animal models,which will serve as the basis for future studies. 展开更多
关键词 ANXIETY cognitive deficit DEPRESSION experimental autoimmune encephalomyelitis motor disability neurological disorder PAIN PATHOPHYSIOLOGY preclinical study sensory impairments
下载PDF
Clinical manifestations,diagnosis and long-term prognosis of adult autoimmune enteropathy:Experience from Peking Union Medical College Hospital 被引量:2
16
作者 Mu-Han Li Ge-Chong Ruan +9 位作者 Wei-Xun Zhou Xiao-Qing Li Sheng-Yu Zhang Yang Chen Xiao-Yin Bai Hong Yang Yu-Jie Zhang Peng-Yu Zhao Ji Li Jing-Nan Li 《World Journal of Gastroenterology》 SCIE CAS 2024年第19期2523-2537,共15页
BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis an... BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis and prognosis.METHODS We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic criteria.RESULTS Diarrhea in AIE patients was characterized by secretory diarrhea.The common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and ileum.Villous blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal biopsies.Moreover,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte antibodies.All patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)days.Immunosuppressants were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s lymphoma.The cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,respectively.CONCLUSION Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult AIE.The long-term prognosis is still unsatisfactory despite corticosteroid and immunosuppressant medications,which highlights the need for early diagnosis and novel medications. 展开更多
关键词 Autoimmune enteropathy Clinical manifestations Diagnostic criteria Pathological features Long-term prognosis
下载PDF
Seismic response of a mid-story isolated structure considering SSI in mountainous areas under long-period earthquakes 被引量:1
17
作者 Wan Feng Qin Shengwu +7 位作者 Liu Dewen Zhao Tiange Zheng Yanping Shan Hang Li Zhiang Peng Fusong Xu Jingran Lei Min 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第1期151-161,共11页
At present,there is not much research on mid-story isolated structures in mountainous areas.In this study,a model of a mid-story isolated structure considering soil-structure interaction(SSI)in mountainous areas is es... At present,there is not much research on mid-story isolated structures in mountainous areas.In this study,a model of a mid-story isolated structure considering soil-structure interaction(SSI)in mountainous areas is established along with a model that does not consider SSI.Eight long-period earthquake waves and two ordinary earthquake waves are selected as inputs for the dynamic time history analysis of the structure.The results show that the seismic response of a mid-story isolated structure considering SSI in mountainous areas can be amplified when compared with a structure that does not consider SSI.The structure response under long-period earthquakes is larger than that of ordinary earthquakes.The structure response under far-field harmonic-like earthquakes is larger than that of near-fault pulse-type earthquakes.The structure response under near-fault pulse-type earthquakes is larger than that of far-field non-harmonic earthquakes.When subjected to long-period earthquakes,the displacement of the isolated bearings exceeded the limit value,which led to instability and overturning of the structure.The structure with dampers in the isolated story could adequately control the nonlinear response of the structure,effectively reduce the displacement of the isolated bearings,and provide a convenient,efficient and economic method not only for new construction but also to retrofit existing structures. 展开更多
关键词 SSI in mountainous areas long-period earthquakes mid-story isolated structure structural dynamic analysis
下载PDF
Highly selective photocatalytic reduction of CO_(2) to CH_(4) on electron-rich Fe species cocatalyst under visible light irradiation 被引量:1
18
作者 Qianying Lin Jiwu Zhao +8 位作者 Pu Zhang Shuo Wang Ying Wang Zizhong Zhang Na Wen Zhengxin Ding Rusheng Yuan Xuxu Wang Jinlin Long 《Carbon Energy》 SCIE EI CAS CSCD 2024年第1期255-266,共12页
Efficient photocatalytic reduction of CO_(2) to high-calorific-value CH4,an ideal target product,is a blueprint for C_(1)industry relevance and carbon neutrality,but it also faces great challenges.Herein,we demonstrat... Efficient photocatalytic reduction of CO_(2) to high-calorific-value CH4,an ideal target product,is a blueprint for C_(1)industry relevance and carbon neutrality,but it also faces great challenges.Herein,we demonstrate unprecedented hybrid SiC photocatalysts modified by Fe-based cocatalyst,which are prepared via a facile impregnation-reduction method,featuring an optimized local electronic structure.It exhibits a superior photocatalytic carbon-based products yield of 30.0μmol g^(−1) h^(−1) and achieves a record CH_(4) selectivity of up to 94.3%,which highlights the effectiveness of electron-rich Fe cocatalyst for boosting photocatalytic performance and selectivity.Specifically,the synergistic effects of directional migration of photogenerated electrons and strongπ-back bonding on low-valence Fe effectively strengthen the adsorption and activation of reactants and intermediates in the CO_(2)→CH_(4) pathway.This study inspires an effective strategy for enhancing the multielectron reduction capacity of semiconductor photocatalysts with low-cost Fe instead of noble metals as cocatalysts. 展开更多
关键词 artificial synthesis of CH_(4) electronic structure optimization Fe species cocatalyst photocatalytic CO_(2) reduction SiC
下载PDF
Emulsifying property,antioxidant activity,and bitterness of soybean protein isolate hydrolysate obtained by Corolase PP under high hydrostatic pressure 被引量:1
19
作者 Haining Guan Chunmei Feng +3 位作者 Min Ren Xiaojun Xu Dengyong Liu Xiaoqin Diao 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1271-1278,共8页
Enzymatic hydrolysis of proteins can enhance their emulsifying properties and antioxidant activities.However,the problem related to the hydrolysis of proteins was the generation of the bitter taste.Recently,high hydro... Enzymatic hydrolysis of proteins can enhance their emulsifying properties and antioxidant activities.However,the problem related to the hydrolysis of proteins was the generation of the bitter taste.Recently,high hydrostatic pressure(HHP)treatment has attracted much interest and has been used in several studies on protein modification.Hence,the study aimed to investigate the effects of enzymatic hydrolysis by Corolase PP under different pressure treatments(0.1,100,200,and 300 MPa for 1-5 h at 50℃)on the emulsifying property,antioxidant activity,and bitterness of soybean protein isolate hydrolysate(SPIH).As observed,the hydrolysate obtained at 200 MPa for 4 h had the highest emulsifying activity index(47.49 m^(2)/g)and emulsifying stability index(92.98%),and it had higher antioxidant activities(44.77%DPPH free radical scavenging activity,31.12%superoxide anion radical scavenging activity,and 61.50%copper ion chelating activity).At the same time,the enhancement of emulsion stability was related to the increase of zeta potential and the decrease of mean particle size.In addition,the hydrolysate obtained at 200 MPa for 4 h had a lower bitterness value and showed better palatability.This study has a broad application prospect in developing food ingredients and healthy foods. 展开更多
关键词 Soybean protein isolate High hydrostatic pressure EMULSIFICATION ANTIOXIDANT Bitter taste
下载PDF
Spatiotemporal changes of gross primary productivity and its response to drought in the Mongolian Plateau under climate change 被引量:1
20
作者 ZHAO Xuqin LUO Min +3 位作者 MENG Fanhao SA Chula BAO Shanhu BAO Yuhai 《Journal of Arid Land》 SCIE CSCD 2024年第1期46-70,共25页
Gross primary productivity(GPP)of vegetation is an important constituent of the terrestrial carbon sinks and is significantly influenced by drought.Understanding the impact of droughts on different types of vegetation... Gross primary productivity(GPP)of vegetation is an important constituent of the terrestrial carbon sinks and is significantly influenced by drought.Understanding the impact of droughts on different types of vegetation GPP provides insight into the spatiotemporal variation of terrestrial carbon sinks,aiding efforts to mitigate the detrimental effects of climate change.In this study,we utilized the precipitation and temperature data from the Climatic Research Unit,the standardized precipitation evapotranspiration index(SPEI),the standardized precipitation index(SPI),and the simulated vegetation GPP using the eddy covariance-light use efficiency(EC-LUE)model to analyze the spatiotemporal change of GPP and its response to different drought indices in the Mongolian Plateau during 1982-2018.The main findings indicated that vegetation GPP decreased in 50.53% of the plateau,mainly in its northern and northeastern parts,while it increased in the remaining 49.47%area.Specifically,meadow steppe(78.92%)and deciduous forest(79.46%)witnessed a significant decrease in vegetation GPP,while alpine steppe(75.08%),cropland(76.27%),and sandy vegetation(87.88%)recovered well.Warming aridification areas accounted for 71.39% of the affected areas,while 28.53% of the areas underwent severe aridification,mainly located in the south and central regions.Notably,the warming aridification areas of desert steppe(92.68%)and sandy vegetation(90.24%)were significant.Climate warming was found to amplify the sensitivity of coniferous forest,deciduous forest,meadow steppe,and alpine steppe GPP to drought.Additionally,the drought sensitivity of vegetation GPP in the Mongolian Plateau gradually decreased as altitude increased.The cumulative effect of drought on vegetation GPP persisted for 3.00-8.00 months.The findings of this study will improve the understanding of how drought influences vegetation in arid and semi-arid areas. 展开更多
关键词 gross primary productivity(GPP) climate change warming aridification areas drought sensitivity cumulative effect duration(CED) Mongolian Plateau
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部