Four new polyhydroxylated steroids plaksterols A–D(1–4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol(5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol(6), were isolated from m...Four new polyhydroxylated steroids plaksterols A–D(1–4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol(5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol(6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.展开更多
The stimulus-responsive room-temperature phosphorescence(RTP)materials have become an increasingly significant topic in the fields of bioimaging,sensing,and anticounterfeiting.However,this kind of materials is scarce ...The stimulus-responsive room-temperature phosphorescence(RTP)materials have become an increasingly significant topic in the fields of bioimaging,sensing,and anticounterfeiting.However,this kind of materials is scarce to date,especially for the ones with delicate stimulus-responsive behavior.Herein,a universal strategy for multilevel thermal erasure of RTP via chromatographic separation of host-guest doping RTP systems is proposed.The tunable host-guest systems,matrix materials,heating temperature,and time are demonstrated to allow precise six-level data encryption,QR code encryption,and thermochromic phosphorescence encryption.Mechanistic study reveals that the thermal-responsive property might be attributed to molecular thermal motion and the separation effect of the silica gel,which provides expanded applications of host-guest RTP materials such as cold chain break detection.This work offers a simple yet universal way to construct advanced responsive RTP materials.展开更多
基金supported by the National Key Research and Development Program of China (No. 2018YFC-0310903)the National Natural Science Foundation of China (Nos.21572210,41776136 and 81991522)NSFC-Shandong Joint Fund for Marine Science Research Centers (No. U1606403)。
文摘Four new polyhydroxylated steroids plaksterols A–D(1–4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol(5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol(6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.
基金This work was supported by the National Natural Science Foundation of China(Nos.21605125 and 22134005)the Natural Science Foundation of Chongqing(No.cstc2020jcyjmsxmX0992).
文摘The stimulus-responsive room-temperature phosphorescence(RTP)materials have become an increasingly significant topic in the fields of bioimaging,sensing,and anticounterfeiting.However,this kind of materials is scarce to date,especially for the ones with delicate stimulus-responsive behavior.Herein,a universal strategy for multilevel thermal erasure of RTP via chromatographic separation of host-guest doping RTP systems is proposed.The tunable host-guest systems,matrix materials,heating temperature,and time are demonstrated to allow precise six-level data encryption,QR code encryption,and thermochromic phosphorescence encryption.Mechanistic study reveals that the thermal-responsive property might be attributed to molecular thermal motion and the separation effect of the silica gel,which provides expanded applications of host-guest RTP materials such as cold chain break detection.This work offers a simple yet universal way to construct advanced responsive RTP materials.
