A MICROCOMPUTER PROGRAM PACKAGE FOR PHARMACOKINETICS AND BIOPHARMACEUTICS

In this paper, a microcomputer program package for pharmacokinetics and biopharmaceutics (PKBP) was presented. This package is applicable to various calculations for pharmacokinetics and biopharmaceutics. Some mathematical models and computing methods were developed. It has been used over 200 users.

Tendency of homogeneous radial deformation during electromagnetic compression of aluminium tube

Electromagnetic forming is one of the high-rate forming methods that can be extensively used to form and join axisymmetric metal sheet and tube. Tendency of homogeneous radial deformation during electromagnetic compression of aluminium tube was investigated through the design optimization method based on sequential coupling numerical simulation and experiments. The results show that the tendency depends on the length ratio of tube to coil (R), which has a critical value (Rc) corresponding to the relatively homogeneous radial deformation along axial direction. The tube length relative to Rc is insensitive to the discharge voltage. When R is greater than Rc, the deformed tube presents horn shape and the shorter coil makes for local deformation. If R is less than Rc, the deformed tube presents drum shape and the longer coil contributes to larger deformation at tube end. Rc increases with coli length and could approach to 1; inversely, it could approach to 0. These results indicate the design optimization method based on the sequential coupling numerical simulation is feasible, which can be used to realize the controllable and precise deformation of metal tube.

Different hybrid machine intelligence techniques for handling IoT-based imbalanced data

In the eta of automatic task processing or designing complex algorithms,to analyse data,it is always pertinent to find teal-life solutions using cutting-edge tools and techniques to generate insights into the data.The data-driven machine learning models are now offering more or less worthy results when they are certainly balanced in the input data sets.Imbalanced data occurs when an unequal distribution of classes occurs in the input datasets.Building a predictive model on the imbalanced data set would cause a model that appears to yield high accuracy but does not generalize well to the new data in the minority class.Now the time has come to look into the datasets which are not so-called Cbalanced,in nature but such datasets are generally encountered frequently in a workspace.To prevent creating models with false levels of accuracy the imbalanced data should be rearranged before creating a predictive model.Those data are,sometimes,voluminous,heterogeneous and complex in nature and generate from different autonomous sources with distributed and decentralized control.The driving force is to efficiently handle these data sets using latest tools and techniques for research and commercial insights.The present article provides different such tools and techniques,in different computing&ameworks,to handle such Internet of Things and other related datasets to review common techniques for handling imbalanced data in data ecosystems and offers a comparative data modelling framework in Keras for balanced and imbalanced datasets.

Fish Production, Water Quality and Bacteriological Parameters of Koi Carp Ponds Under Live-food and Manure Based Management Regimes

To test the effectiveness of introducing live zooplankton against direct manuring in ornamental fish ponds upon their survival and production, larvae of koi carp, Cyprinus carpio L., were cultured for 11 weeks in earthen ponds maintained according to four management regimes： （1） live zooplankton fed to carp larvae （LF）; （2） direct fertilization with poultry manure （PM）; （3） direct fertilization with cowdung （CD）; and （4） a control treatment （C）. There were three replicates for each treatment. The growth of heterotrophic bacteria and pathogenic microorganisms like Aeromonas sp. and Pseudomonas sp. were also examined in response to pond management. Values of dissolved oxygen were significantly higher （P〈0.05） in the water of LF ponds, compared to other treatments, while the PM and CD treatments recorded were significantly higher （P〈0.05） values of PO4 - P, NH4 - N, NO3 - N, NO2 - N, specific conductivity, alkalinity, and BOD, compared to the LF and C treatments. The percentages of organic carbon and total nitrogen in the bottom sediments were higher in the PM and CD treatments compared to LF （P〈0.05）. Average counts of heterotrophic bacteria in the water of PM and CD ponds were significantly higher than other treatments （P〈0.05）. The development of Aeromonas sp. and Pseudomonas sp. were significantly higher （P〈0.05） in the PM and CD treatments. Weight gain of koi carp stocked in LF was significantly higher （P〈0.05） than that of fish in the other treatments. There was a significant difference in the survival rate of koi carp among the treatments ranging from 67.21% in C to 90.11% in LF. The results suggest that raising koi carp larvae in ponds and feeding them exogenously with zooplankton would support high rates of survival and production through maintenance of better water quality and greater abundance of zooplankton in the system. Significantly lower abundance of Aeromonas sp. and Pseudomonas sp. in the LF treatment considerably lowered any possibility of occurrence of bacterial disease.

NUMERICAL SIMULATION OF OIL MIGRATION-ACCUMULATION OF MULTILAYER AND ITS APPLICATION

From such actual conditions as the effects of fluid mechanics in porous media and three-dimensional geology characteristics, the mathematical model and a kind of modified method of second order splitting-up implicit iterative scheme were put forward. For the actual problem of Dongying hollow (single layer) and Huimin hollow (multilayer) of Shengli Petroleum Oil Field, this numerical simulation test and the actual conditions are basically coincident, thus the well-known problem has been solved.

Controlling Diffusion by Varying Width of Layers in Nano Channel

Diffusive dynamics of fluid forming layers of high and low density regions in a nanochannel has been investigated.Diffusion coefficient in direction parallel and perpendicular to the confining wall has been found to show behaviour which is not observed in micro channel or bulk systems.The behaviour of diffusion is found to be controlled by the width of layers formed in nanochannel due to wall and particle interactions.This is an important result as width of layers and hence flow of fluid inside nano pores/tube can be controlled by an external source.

An ab initio Study on the Structural and Bonding Properties of Li_2Si_3O_7

A theoretical study on the structural and electronic properties of Li2Si3O7 is performed by using density functional theory（DFT） method.The molecular structure of the crystal and two kinds of [SiO4]-tetrahedra with different number of non-bridging oxygen（Qn） are analyzed.The structure of crystal Li2Si3O7 can be considered as a framework of corner-sharing tetrahedra.From the band structure（BS）,total density of state（TDOS） and projected density of state（PDOS） of the crystal,the structures of Q3,Q4,and LiO4 tetrahedra as well as their bonding characters are presented.For lithium trisilicate,we find the bond cation-NBO（nonbridging oxygen and oxygen atoms bonding to one silicon atom only） is stronger than the bond cation-BO（bridging oxygen and oxygen atoms bonding to two silicon atoms）.By analyzing the ionicity of two different types of bonds of silicon-oxygen according to the Mulliken population analysis,we also find that the Si-NBO bonds have higher ionicity than Si-BO for crystalline lithium trisilicate,which agrees with other lithium silicates.

Remote Scheduling System for Drip Irrigation System Using Geographic Information System

The Internet is widely accessible in Tanzania. Most of the technologies used in different organizations have changed to address their functions using web based information systems. In this paper, attempt is made to design software system using geographical information system (GIS) for the spatial and temporal distribution of irrigation supply for large-scale drip irrigation systems in Tanzania. Map based information system has gained popularity after evolution of simple tools to present spatial information using Internet. Due to water scarcity, it is envisioned that by 2050 the world won’t have enough water for communities, industries and agriculture. Web based precision irrigation system refers to deployment of remotely precision irrigation services using the application interface that connects to the Internet. Hence, this study presents the GIS in the context of precision farming to achieve precision irrigation strategy with special reference to precision farming of tea in Tanzania. The GIS-based irrigation scheduling system was designed for the scheduling daily drip irrigation water deliveries and regular monitoring of irrigation delivery performance for maximum yield. The “Scheduling” program computes the right amount of irrigation deliveries based on tea water requirements. The “Monitoring” program gives information on the uniformity of water distribution and the shortfall or excess.

Magnetic Resonance Imaging and DWI Features of Orbital Rhabdomyosarcoma

Purpose: To describe the magnetic resonance imaging(MRI)features of orbital rhabdomyosarcoma(RMS).Methods: Thirty-nine patients with histopathologically confirmed orbital RMS were retrospectively reviewed. All patients underwent orbital conventional MRI, including axial, sagittal,and coronal T1-weighted, T2-weighted, and postcontrast T1-weighted sequences. The location, shape, margin, and MRI signal of the 39 lesions were reviewed. DWI in 15 patients and susceptibility weighted imaging(SWI) in 2 patients were also analyzed.Results: Orbital MRI was available in 39 patients and revealed a soft tissue mass in the orbital region in all cases. Of the 39 patients, the primary tumor sites were limited to the orbital proper in 31 cases, while 28 cases had extraocular muscle invasion and 8 cases had extraorbital invasion. All lesions were unilateral. Thirty-three cases were well-defined soft tissue masses and 6 cases appeared as less well-defined softtissue masses. Thirty-four cases showed homogeneous isointense or slightly hypointense signals on T1-weighted imaging(T1WI) and hyperintense signal on T2-weighted imaging(T2WI) compared with extraocular muscles. Five cases had heterogeneous signals with focal areas of increased signal on T1WI or decreased signal on T2WI, including 1 case with hypointense signal on SWI. The mean apparent diffusion coefficient(ADC) value of the viable part of tumors was(0.925±0.09)×10-3mm2/ s. All cases showed moderate to marked enhancement after contrast administration.Conclusion: Several MRI features-including homogeneous isointense or slightly hypointense signal on T1WI and slightly hyperintense signal on T2WI, relative low ADC values, and moderate to marked enhancement, extraocular muscles invasion, and extraorbital extensionare helpful in the diagnosis of orbital RMS.

Optical and Acoustic Branches in the Vibrational Spectrum of a Diatomic Penrose Lattice

Vibrational dejisitics of states for a diatomic Penrose lattice are calculated.They show apparently acoustic and optical brandies.The acoustic branches appear smooth and continuous, while the optical branches are peakrich and liave some small gaps.Detailed analysis shows thut the denftity of states in the acoustic branches is attributedl to the phonons and the fracton-like excitations and.that in the optical blanches due to some localized vibrational modes.

以标准化发展信息化

香港大学的IT部门要求所有的员工必须学习ITIL的课程培训并通过考核。

Model Study of Basin Soil Loss (BSL) in the Loess Plateau of China (Ⅱ)

According to the influence of underlayer factor upon the basin erosion and in the support of Geographic Information System (GIS) of Loess Plateau(LPIS), the Gushanchuan Basin is divided into several regions with different erosion intensity. Correlating them to the BSL quantity, the complete soil loss model is established. By using this model, the soil loss quantity of the whole basin as well as each erosion intensity region can be estimated.

Scaling relation of domain competition on(2+1)-dimensional ballistic deposition model with surface diffusion

During heteroepitaxial overlayer growth multiple crystal domains nucleated on a substrate surface compete with each other in such a manner that a domain covered by neighboring ones stops growing.The number density of active domains ρ decreases as the height h increases.A simple scaling argument leads to a scaling law of ρ~ h^（-γ） with a coarsening exponent γ=d/z,where d is the dimension of the substrate surface and z the dynamic exponent of a growth front.This scaling relation is confirmed by performing kinetic Monte Carlo simulations of the ballistic deposition model on a two-dimensional（d=2） surface,even when an isolated deposited particle diffuses on a crystal surface.