AIM:To investigate effects of anti-TNF biologic drugs on uveitis severity(comparing visual acuity log MAR levels) in Behcet patients.METHODS:Three databases Pub Med, Scopus, and the Web of Science were searched for qu...AIM:To investigate effects of anti-TNF biologic drugs on uveitis severity(comparing visual acuity log MAR levels) in Behcet patients.METHODS:Three databases Pub Med, Scopus, and the Web of Science were searched for qualified papers focusing on the anti-TNF-α factors treatment in Behcet’s disease(BD)-associated uveitis. Studies that were designed pre and post anti-TNF drug treatment, were selected. After determining the search strategy for this study, the relevant data were extracted. RESULTS:The initial search was performed in the target databases and a total of about 1458 articles were found. Fifteen articles were selected for systematic review and only 12 of them had inclusion criteria for Meta-analysis(with visual acuity data). The mean dose of prednisolone before and after biological treatments was reported in 5 studies(28.56 and 7.56 mg/kg, respectively). Also, the preliminary results indicate a significant reduction in visual acuity log MAR levels(MD=-1.5 IU/L, 95%CI:-2.1,-0.01).CONCLUSION:Biological drugs significantly reduce the dose of prednisolone and affect visual acuity values.展开更多
Introduction: Osteoporosis is a multifactorial skeletal disease that is characterized by reduced bone mineral density (BMD). BMD values depend on several factors such as age, sex and age at menopause. The purpose of t...Introduction: Osteoporosis is a multifactorial skeletal disease that is characterized by reduced bone mineral density (BMD). BMD values depend on several factors such as age, sex and age at menopause. The purpose of this study was to determine the prevalence and changes in bone mineral density in Iranian patients. Methods: Three hundred patients were selected through random sampling technique in 2009. BMD was assessed by Norland (Excell) technique at the lumbar and femoral neck. Weight and height were measured through standard methods. A thorough history was taken from each patient. The data was analyzed using SPSS software version 13.0. P-values less than 0.05 were considered statistically significant. Results: From among the 300 studied patients, 86.6% were female. their mean age was 52.7 years. Their average body mass index (BMI) was 28.14 kg/m2. Mean T-Score at lumbar spine and femoral neck was -1.07 ±1.19 and -1.75 ± 1.33 respectively. Mean BMD value at lumbar spine and femoral neck was 0.92 ± 0.19 and 0.77 ± 0.16 respectively. The prevalence of osteoporosis at lumbar spine and femoral neck was 33.7% and 16.7, respectively. There was a significant correlation between age, BMI and BMD values (P-Value Conclusion: This study shows that ageing and low BMI are risk factors associated with bone loss. it is recommended to measure BMD and implement prevention programs for high-risk people.展开更多
To the Editor,Systemic lupus erythematosus(SLE)is a chronic autoimmune systemic disease in which the immune system attacks healthy cells and tissues throughout the body with a broad variety of clinical manifestations,...To the Editor,Systemic lupus erythematosus(SLE)is a chronic autoimmune systemic disease in which the immune system attacks healthy cells and tissues throughout the body with a broad variety of clinical manifestations,and is more prevalent in African American women and women than in other ethnic minority groups.1 The maximum estimation for the prevalence of SLE in the United States is about 320,000 patients.2 However,the first presentation of SLE often mimics a viral syndrome with constitutional symptoms,like,a low-grade fever,fatigue,and weight loss,and maybe arthralgia or arthritis;it may present in several other ways and have an abrupt onset with target-organ involvement,particularly in Hispanics(61%)and African Americans(45%)compared with Whites(41%).1 Neurological manifestations are common in SLE,named neuropsychiatric SLE,and its prevalence ranges between 14%and 95%,which is more common in children than adults.The involvement of the nervous system is coupled with worse outcomes and mortality rates vary from 2%to 45%.Psychoses,seizures,and cranial nerve involvement,in particular,have been given much emphasis.Besides,visual defects secondary to involvement of the visual pathways posterior to the optic chiasm,presenting as homonymous hemianopia,were rarely reported in SLE.3-5 On the other hand,homonymous hemianopia as the first manifestation of SLE is extremely rare in the literature.In this paper,we present a patient who experienced homonymous hemianopia as the initial presentation of SLE.展开更多
文摘AIM:To investigate effects of anti-TNF biologic drugs on uveitis severity(comparing visual acuity log MAR levels) in Behcet patients.METHODS:Three databases Pub Med, Scopus, and the Web of Science were searched for qualified papers focusing on the anti-TNF-α factors treatment in Behcet’s disease(BD)-associated uveitis. Studies that were designed pre and post anti-TNF drug treatment, were selected. After determining the search strategy for this study, the relevant data were extracted. RESULTS:The initial search was performed in the target databases and a total of about 1458 articles were found. Fifteen articles were selected for systematic review and only 12 of them had inclusion criteria for Meta-analysis(with visual acuity data). The mean dose of prednisolone before and after biological treatments was reported in 5 studies(28.56 and 7.56 mg/kg, respectively). Also, the preliminary results indicate a significant reduction in visual acuity log MAR levels(MD=-1.5 IU/L, 95%CI:-2.1,-0.01).CONCLUSION:Biological drugs significantly reduce the dose of prednisolone and affect visual acuity values.
文摘Introduction: Osteoporosis is a multifactorial skeletal disease that is characterized by reduced bone mineral density (BMD). BMD values depend on several factors such as age, sex and age at menopause. The purpose of this study was to determine the prevalence and changes in bone mineral density in Iranian patients. Methods: Three hundred patients were selected through random sampling technique in 2009. BMD was assessed by Norland (Excell) technique at the lumbar and femoral neck. Weight and height were measured through standard methods. A thorough history was taken from each patient. The data was analyzed using SPSS software version 13.0. P-values less than 0.05 were considered statistically significant. Results: From among the 300 studied patients, 86.6% were female. their mean age was 52.7 years. Their average body mass index (BMI) was 28.14 kg/m2. Mean T-Score at lumbar spine and femoral neck was -1.07 ±1.19 and -1.75 ± 1.33 respectively. Mean BMD value at lumbar spine and femoral neck was 0.92 ± 0.19 and 0.77 ± 0.16 respectively. The prevalence of osteoporosis at lumbar spine and femoral neck was 33.7% and 16.7, respectively. There was a significant correlation between age, BMI and BMD values (P-Value Conclusion: This study shows that ageing and low BMI are risk factors associated with bone loss. it is recommended to measure BMD and implement prevention programs for high-risk people.
文摘To the Editor,Systemic lupus erythematosus(SLE)is a chronic autoimmune systemic disease in which the immune system attacks healthy cells and tissues throughout the body with a broad variety of clinical manifestations,and is more prevalent in African American women and women than in other ethnic minority groups.1 The maximum estimation for the prevalence of SLE in the United States is about 320,000 patients.2 However,the first presentation of SLE often mimics a viral syndrome with constitutional symptoms,like,a low-grade fever,fatigue,and weight loss,and maybe arthralgia or arthritis;it may present in several other ways and have an abrupt onset with target-organ involvement,particularly in Hispanics(61%)and African Americans(45%)compared with Whites(41%).1 Neurological manifestations are common in SLE,named neuropsychiatric SLE,and its prevalence ranges between 14%and 95%,which is more common in children than adults.The involvement of the nervous system is coupled with worse outcomes and mortality rates vary from 2%to 45%.Psychoses,seizures,and cranial nerve involvement,in particular,have been given much emphasis.Besides,visual defects secondary to involvement of the visual pathways posterior to the optic chiasm,presenting as homonymous hemianopia,were rarely reported in SLE.3-5 On the other hand,homonymous hemianopia as the first manifestation of SLE is extremely rare in the literature.In this paper,we present a patient who experienced homonymous hemianopia as the initial presentation of SLE.
