Recently, typing of polymorphisms on the X chromosome has become a standard technique in forensic genetics and a growing number of short tandem repeats (STR) has been established in this chromosome related to genetic ...Recently, typing of polymorphisms on the X chromosome has become a standard technique in forensic genetics and a growing number of short tandem repeats (STR) has been established in this chromosome related to genetic population studies. Knowledge of marker recombination is very important especially when the X chromosome typing is used in forensic kinship analysis. It is known that the meiotic recombination is not a simple function of the physical distance between segments of the DNA but the recombination events between them tend to be clustered at special regions of the chromosome. Information on the rate of recombination among markers can be gathered by studying families through several generations. In this work we have typed DNA samples of pedigree consisting of nineteen families in Rio de Janeiro, constituted of grandfather, mother and grandson, and in some cases grandmother and aunt, and reported the recombination of 10 STR markers of the X chromosome. The study of the linkage analysis using the LOD score has shown that the marker pairs DXS8378-DXS7423, DXS7132-DXS9898, DXS7132-GATA172D05 DXS9898-DXS7133 and DXS6809-DXS7133 are not transmitted in a random way, during a recombination event.展开更多
Here we constructed a charged gravastar model formed by an interior de Sitter spacetime, a charged dynamical infinitely thin shell with an equation of state and an exterior de Sitter-Reissner-Nordstrom spacetime. We f...Here we constructed a charged gravastar model formed by an interior de Sitter spacetime, a charged dynamical infinitely thin shell with an equation of state and an exterior de Sitter-Reissner-Nordstrom spacetime. We find that the presence of the charge is crucial to the stability of these structures. It can as much favor the stability of a bounded excursion gravastar, and still converting it in a stable gravastar, as make disappear a stable gravastar, depending on the range of the charge considered. There is also formation of black holes and, above certain values, the presence of the charge allows the formation of naked singularity. This is an important example in which a naked singularity emerges as a consequence of unstabilities of a gravastar model, which reinforces that gravastar is not an alternative model to black hole.展开更多
基金the financial support granted by Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro(FAPERJ),DNA Program-State University and Justice Court of Rio de Janeiro,Brazil and R.C.
文摘Recently, typing of polymorphisms on the X chromosome has become a standard technique in forensic genetics and a growing number of short tandem repeats (STR) has been established in this chromosome related to genetic population studies. Knowledge of marker recombination is very important especially when the X chromosome typing is used in forensic kinship analysis. It is known that the meiotic recombination is not a simple function of the physical distance between segments of the DNA but the recombination events between them tend to be clustered at special regions of the chromosome. Information on the rate of recombination among markers can be gathered by studying families through several generations. In this work we have typed DNA samples of pedigree consisting of nineteen families in Rio de Janeiro, constituted of grandfather, mother and grandson, and in some cases grandmother and aunt, and reported the recombination of 10 STR markers of the X chromosome. The study of the linkage analysis using the LOD score has shown that the marker pairs DXS8378-DXS7423, DXS7132-DXS9898, DXS7132-GATA172D05 DXS9898-DXS7133 and DXS6809-DXS7133 are not transmitted in a random way, during a recombination event.
基金The financial assistance from FAPERJ/UERJ(CFCB and MFAdaS)is gratefully acknowledgedThe authors(RC,MFAdaS)acknowledge the financial support from FAPERJ(no.E-26/171.754/2000,E-26/171.533/2002,E-26/170.951/2006,E-26/110.432/2009 and E-26/111.714/2010)+1 种基金The authors(RC and MFAdaS)also acknowledge the financial support from Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq-Brazil(no.450572/2009-9,301973/2009-1 and 477268/2010-2)The author(MFAdaS)also acknowledges the financial support from Financiadora de Estudos e Projetos-FINEP-Brazil(Ref.2399/03).
文摘Here we constructed a charged gravastar model formed by an interior de Sitter spacetime, a charged dynamical infinitely thin shell with an equation of state and an exterior de Sitter-Reissner-Nordstrom spacetime. We find that the presence of the charge is crucial to the stability of these structures. It can as much favor the stability of a bounded excursion gravastar, and still converting it in a stable gravastar, as make disappear a stable gravastar, depending on the range of the charge considered. There is also formation of black holes and, above certain values, the presence of the charge allows the formation of naked singularity. This is an important example in which a naked singularity emerges as a consequence of unstabilities of a gravastar model, which reinforces that gravastar is not an alternative model to black hole.
