Interleukin-12(IL-12) is a critical cytokine representing the link between the cellular and humoral branches of host immune defense apparatus.IL-12-induced cytotoxic lymphocyte(CTL) development is a central mechanism ...Interleukin-12(IL-12) is a critical cytokine representing the link between the cellular and humoral branches of host immune defense apparatus.IL-12-induced cytotoxic lymphocyte(CTL) development is a central mechanism in immune responses against intracellular infectious agents as well as malignant growth.However, the molecular basis of tumor-specific CTL responses mediated by IL-12 remains poorly defined.In this study, we addressed this issue in a comprehensive manner to probe into IL-12-induced anti-tumor responses by global gene expression profiling of mRNA expression in CD8^+ T cells in a transplantable syngeneic mouse mammary carcinoma model treated or not with recombinant IL-12.A strong tumor regression was induced by the IL-12 treatment.An introspection of differential gene expression at an early stage of the IL-12-initiated CTL activation reveals interesting genes and molecular pathways that may account for the marked tumor regression, and is likely to provide a rich source of potential targets for further research and development of effective therapeutic modalities.Cellular & Molecular Immunology.2004;1(5):357-366.展开更多
文摘Interleukin-12(IL-12) is a critical cytokine representing the link between the cellular and humoral branches of host immune defense apparatus.IL-12-induced cytotoxic lymphocyte(CTL) development is a central mechanism in immune responses against intracellular infectious agents as well as malignant growth.However, the molecular basis of tumor-specific CTL responses mediated by IL-12 remains poorly defined.In this study, we addressed this issue in a comprehensive manner to probe into IL-12-induced anti-tumor responses by global gene expression profiling of mRNA expression in CD8^+ T cells in a transplantable syngeneic mouse mammary carcinoma model treated or not with recombinant IL-12.A strong tumor regression was induced by the IL-12 treatment.An introspection of differential gene expression at an early stage of the IL-12-initiated CTL activation reveals interesting genes and molecular pathways that may account for the marked tumor regression, and is likely to provide a rich source of potential targets for further research and development of effective therapeutic modalities.Cellular & Molecular Immunology.2004;1(5):357-366.
