A universal platform with M_n doping and hyaluronic acid （HA） modification, based on mesoporous silica （mSiO2）, was designed and used as a basic multifunctional material with magnetic resonance （MR） imaging. Fur...A universal platform with M_n doping and hyaluronic acid （HA） modification, based on mesoporous silica （mSiO2）, was designed and used as a basic multifunctional material with magnetic resonance （MR） imaging. Furthermore, we added flexible functions through the addition of functional molecules. Specially, two typical compounds, hydrophobic perfluorooctyl bromide （PFOB） and hydrophilic doxorubicin （DOX）, were loaded into the channels to obtain PFOB@Mn@mSiO2@HA （PMMH） or DOX@Mn@mSiO2@HA （DMMH） or imaging and therapy, respectively. The were highly targeted to the lymph system in nanoparticles for dual-mode imaging PMMH and DMMH nanoparticles vitro and in vivo. MR and ultrasound imaging of PMMH nanoparticles were performed in the lymph system, while MR imaging and chemotherapy of DMMH nanoparticles was used to detect cancer. These results showed that both PMMH and DMMH nanoparficles can be designed with high lymph targeting efficiency. PMMH nanoparticles are a dual-mode contrast agent for both ultrasound and MR imaging for the lymph system and DMMH nanoparticles are powerful agents for the combined diagnosis and therapy of cancer in vivo.展开更多
基金The work is supported by Shanghai Rising-Star Program （No. 13QB1402200）, Shanghai Minhang district talent development special fund, National Key Technology Research and Development Program （No. 2014BAK05B02） and National Natural Science Foundation of China （Nos. 81271638 and 81371622）.
文摘A universal platform with M_n doping and hyaluronic acid （HA） modification, based on mesoporous silica （mSiO2）, was designed and used as a basic multifunctional material with magnetic resonance （MR） imaging. Furthermore, we added flexible functions through the addition of functional molecules. Specially, two typical compounds, hydrophobic perfluorooctyl bromide （PFOB） and hydrophilic doxorubicin （DOX）, were loaded into the channels to obtain PFOB@Mn@mSiO2@HA （PMMH） or DOX@Mn@mSiO2@HA （DMMH） or imaging and therapy, respectively. The were highly targeted to the lymph system in nanoparticles for dual-mode imaging PMMH and DMMH nanoparticles vitro and in vivo. MR and ultrasound imaging of PMMH nanoparticles were performed in the lymph system, while MR imaging and chemotherapy of DMMH nanoparticles was used to detect cancer. These results showed that both PMMH and DMMH nanoparficles can be designed with high lymph targeting efficiency. PMMH nanoparticles are a dual-mode contrast agent for both ultrasound and MR imaging for the lymph system and DMMH nanoparticles are powerful agents for the combined diagnosis and therapy of cancer in vivo.
