Global Effect of Climate Change on Seasonal Cycles,Vector Population and Rising Challenges of Communicable Diseases:A Review

This article explains ongoing changes in global climate and their effect on the resurgence of vector and pathogen populations in various parts of the world.Today,major prevailing changes are the elevation of global temperature and accidental torrent rains,floods,droughts,and loss of productivity and food commodities.Due to the increase in water surface area and the longer presence of flood water,the breeding of insect vectors becomes very high;it is responsible for the emergence and re-emergence of so many communicable diseases.Due to the development of resistance to chemicals in insect pests,and pathogens and lack of control measures,communicable zoonotic diseases are remerging with high infectivity and mortality.This condition is becoming more alarming as the climate is favoring pathogen-host interactions and vector populations.Rapid changes seen in meteorology are promoting an unmanageable array of vector-borne infectious diseases,such as malaria,Japanese encephalitis,filarial,dengue,and leishmaniasis.Similarly,due to unhygienic conditions,poor sanitation,and infected ground and surface water outbreak of enteric infections such as cholera,vibriosis,and rotavirus is seen on the rise.In addition,parasitic infection ascariasis,fasciolosis,schistosomiasis,and dysentery cases are increasing.Today climate change is a major issue and challenge that needs timely quick solutions.Climate change is imposing non-adaptive forced human migration territorial conflicts,decreasing ecosystem productivity,disease outbreaks,and impelling unequal resource utilization.Rapid climate changes,parasites,pathogens,and vector populations are on the rise,which is making great threats to global health and the environment.This article highlighted the necessity to develop new strategies and control measures to cut down rising vector and pathogen populations in endemic areas.For finding quick solutions educational awareness,technology up-gradation,new vaccines,and safety measures have to be adopted to break the cycle of dreadful communicable diseases shortly.

Morphological Changes and Antioxidant Activity of <i>Stevia rebaudiana</i>under Water Stress

Stevia rebaudiana, a herbaceous perennial shrub contains steviol glycosides, as an alternative source of sugar for diabetic patients. Water being an integral part plays a vital role in the maintenance of plant life. Availability of water is one of the limiting factors determining plant distribution and survival in natural ecosystem. The objective of this study was to investigate the ability of tolerance of Stevia plants to water stress. Potted plants of Stevia were subjected to different levels of water regimes (100 ml, 200 ml, 300 ml) per day, whereas control plants were watered daily with about 400 ml water. Plant height, leaf area, electrolyte leakage and antioxidant enzyme activity (peroxidase and catalase) were assayed during the experimental period. All these parameters were severely affected under water stress condition. Stress treatment caused an increase in electrolyte leakage compared to control. Plant height decreased under severe stress condition whereas a sharp increase in antioxidant enzyme activity was observed in stressed plants as compared to untreated control plants. Our experiment emphasizes the importance of proper watering schedule for the cultivation of Stevia as an agricultural crop to meet the challenges for sugar and energy crisis.

Microwave assisted synthesis,spectroscopy and biochemical aspects of lanthanum(Ⅲ) and praseodymium(Ⅲ) complexes with oxadiazole functionalised dithiocarbazinates

The new lanthanum (Ⅲ) and praseodymium (Ⅲ) complexes of the general formula [Ln(L)3] (Ln=La(Ⅲ) or Pr(Ⅲ); LK=potassium salt of dithiocarbazinates) were prepared by both, conventional thermal and by the use of microwave technology. Elemental analyses, electrical conductance, magnetic moment and electronic, infrared, far-infrared, 1H and 13C NMR spectral studies were used to characterize the complexes. The molecular weights of few complexes were determined by FAB-mass spectra. Nephelauxetic ratio, covalency parameter and bonding parameter for these complexes were also calculated. The probable structures of the complexes were proposed. The antifungal and antibacterial activities of the complexes were evaluated. The activities were correlated with the structures of the compounds.

Effects of plant latex based anti-termite formulations on Indian white termite <i>Odontotermes obesus</i>(Isoptera: Odontotermitidae) in sub-tropical high infestation areas

In the present investigation various bioassays were conducted to evaluate the anti-termite efficacy of plant latex based formulations to control population of Indian white termite in subtropical soil. Results reveal that crude latex, its fractions and combinatorial fractions have shown very high toxicity against O. obesus. The LD50 values for different latex fractions of 24 h were in a range of 5.0-17.613 μg/mg while combined mixtures of Calotropis procera have shown synergistic activity against termites and caused comparably high mortality with LD50 1.987-6.016 μg/mg. The mortality rate was found dose and time dependent as it was found to be increased with an increase in dose and exposure period. In olfactometry tests, C. procera latex solvent fractions have shown significant repellency at a very low dose 0.010-0.320 μg/mg. Interestingly, solvent fractions have significantly repelled large numbers of worker termites due to volatile action of active components of latex and different additives. ED50 values obtained in crude latex were 0.121 μg/mg body weights while combinatorial formulations have shown ED50 in between 0.015-0.036 μg/mg. Statistical analysis of repelled and un-repelled termites gave a low Chi-square value (X2 value = 0.890) which is an indicator of independence of repellent action in randomly selected termite groups. In field experiments pre-soaked cotton threads impregnated with Calotropis procera crude latex were tagged around tree trunks of Tectona grandis provided a wider protection against O. obesus. By employing these pre-coated threads, termite infestation and tunneling activity were significantly decreased (p Calotropis procera possesses enough anti-termite potential against Indian white termite, O. obesus population. If used these, formulations may also provide wide a range of control against other kinds of pests including house hold, medical and veterinary. However, Calotropis procera latex based formulations can be recommended for effective control of termites in high infestation areas by applying spray, or in form of poison baits or as fumigant in pure form.

Study of Intermolecular Interactions in Liquid Crystals: Para-butyl-p’-cyano-biphenyl

Various characteristics of mesomorphism can be explained using intermolecular interactions between a pair of liquid crystalline molecules. The intermolecular interactions have been calculated considering multipole-multicentere expansion method and modified by second order perturbation treatments. For calculation of multipole i.e. charge, dipole, etc. at each atomic center of molecules, para-butyl-p’-cyano-biphenyl, GAMESS, an ab initio program, with 6-31G* basis set has been used. The stacking, in-plane and terminal interaction energies explain the liquid crystalline behaviour of the system.

A Method for Polarizing More Number of Impurity-Vacancy Dipoles

Free rotating impurity-vacancy (IV) dipoles in an alkali halide matrix are polarized to the extent of 1/3 of the total number of IV dipoles. An experimental procedure is suggested in this article which will help in the polarization of IV dipoles to the extent of 2/3 of the total number of IV dipoles. In the suggested experimental procedure, the electric field will be applied at first in one direction and then will be applied in succession in opposite direction. Ionic thermocurrent technique is employed to ascertain the increase in polarization of IV dipoles.

Markers for Global Climate Change and Its Impact on Social, Biological and Ecological Systems: A Review

Present article sketches out major climate induced changes in marine, aquatic and terrestrial life. Few important biomarkers such as ecological, meteorological, socioeconomic, thermal, biophysical and biological, behavioral markers of climate change and global environmental stress have been highlighted to predict the future challenges and finding appropriate solutions. Though, so many climate change induced effects are visible but few unpredictable effects may be seen in future. Therefore, all such effects have been acknowledged, and tried to find appropriate solutions. Most visible effect is collection of high amounts of carbon dioxide in the atmosphere which is responsible for green house effect and causing natural calamities round the globe. It is not only jeopardized the survival of terrestrial, fresh water animals mainly planktons, bottom dwellers;coral reefs, algae, fish fauna in marine environment belong to different taxon but also responsible for disruption of ocean’s food web due to non-assimilation of extra carbon dioxide by the ocean water. There is a sharp decline in fresh water and sea shore micro-flora and micro-fauna. Other major visible effects are loss of biodiversity, depletion of forests, land degradation, severe floods and draughts. On other hand sudden changes in weather conditions causing irreparable devastations due to hurricanes and typhoons, storms, lightening, earthquakes and tsunamis are normally on rise. Both economic and ecological breakdowns are occurring more frequently which are more impactful and persistent. Climate change is major human health stressor;it is making fragmentation of socio-cultural bonds and reducing fertility of soil finally crop production. Climate change is imposing non-adaptive forced human migration, territorial conflicts, decreasing ecosystem productivity, disease out breaks, and impelling unequal resource utilization.

Antimicrobial Activity of Fruit Latexes from Ten Laticiferous Plants

In the present investigation antibacterial activity of latexes from ten Indian plant species Spondias dulcis (Amra), Diospyros melanoxylon (Tendu), Terminalia bellirica (Wahera), Ficus glomerata (Gular), Phyllanthus emblica (Awla), Thevetia nerifolia (Kaner), Carica papaya (Papita), Calotropis procera (Ak), Ficus benghalensis (Bargad), Atrocarpus heterophyllus (Kathal) collected from Go-rakhpur, North India were determined in various in vitro systems. MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) values were determined in growth inhibitory bioassays by using different increasing concentrations of various latex extracts. Latex samples were diluted by using serial micro dilution method up to 10-10 method with Luria broth culture medium. These values were obtained significantly 2 - 3 times lower than that of broad spectrum antibiotic drugs. Besides this, inhibition zone diameters were measured in agar disc diffusion assay. A known volume i.e. 0.1 - 20 μg/μl of each latex were coated on separate sterile filter paper discs (Whatman No. 1) measuring 6 mm in size. Latex fractions registered significantly higher growth inhibition than that of broad spectrum antimicrobial drugs. Present study indicates the potential use of shows that both latex and its components and latex as are valuable source of medicinal products/active principles that can be used for treatment of life threatening infectious diseases. Because of higher inhibitory and cidal potential obtained in latexes than the synthetic drugs these that could lead to become efficient phytomedicines mainly to have and develop as complete drug formulations against to control infectious microbes.

Anti-bacterial Properties of Transition Metal Complexes of Copper Metal Ion:A Mini Review

Bacterial infections are a major cause for impulsive deaths in human beings.Bacterial infections of the respiratory,gastrointestinal and central nervous system account for the majority of cases of sudden casualties.Readily available drugs are getting ineffective by each passing day as the mutation is very fast in these pathogenic microbes resulting in drug resistance.The growing resistance of bacteria necessitates the development of new and effective compounds of desired characteristics that could bar the rapid development of bacterial cell inside of the host body.Along with cellular resistance for clinical antibiotics,co-bacterial infections during microbial attacks(viz.virus,fungus,protozoans etc.)also demand for some novel antibacterial drugs having high efficacy and minimal side effects on human body.These antibiotics should also be compatible with remedies ongoing for core microbial infections.So,in demand of search for effective antibacterial moieties,the scope of transition metal complexes as drug gives a good signal against the pathogenic bacteria by inhibiting their growth.The action of metal complexes on bacterial cell may be due to impremiablity,enzymatic interruptions,ribosomal interactions,disturbance in the path of protein synthesis,denaturing of genetic materials etc.inside the cell.Metals in complexes may interrupt the lipophilisity through the bacterial cell wall.Inclusion of metal ions in organic moieties behaving as ligand delocalizeπ-electrons upon the entire chelate ring and this chelation results in overlapping of ligand orbital and partial sharing of(+)ve charge of metal ion with donor atoms.These structural modifications in metal and organic lone pair donor species are the supposed reasons for their enhanced antimicrobial activities against pathogenic microbes.The present review focuses on the impact of recently synthesized,well characterized mono and binuclear transition metal complexes of Cu ions that have the potential to be the drug of the decade in medicinal inorganic chemistry for treating the bacterial diseases.