洲际酒店、DFS环球免税集团国际强手联合打造奢华盛宴——“感受洲际,享受生活”时尚慈善晚会

由成都世纪城洲际大饭店、DFS环球免税集团联合打造的一场奢华盛宴——“感受洲际，享受生活”时尚慈善鸡尾酒派对，3月18日晚在成都世纪城洲际大饭店隆重举行。这场盛宴因为由洲际酒店和DFS环球免税集团的强强联手令成都的夜晚更加光芒璀璨，更添时尚奢华。

CXCR4+ and SDF-1+ Bone Marrow Cells Are Mobilized into the Blood Stream in Acute Myocardial Infarction and Acute Ischemia

Cell therapy has shown beneficial effects on ventricular function and tissue regeneration in patients with acute and chronic myocardial infarction, although with diverse grades of variability in the results, possibly by proportion, subtype and cell cycle status. Objective: Identify and phenotypically characterize, via CXCR4 and SDF-1 expression, the bone marrow cell subpopulations that are mobilized into the bloodstream in patients with Acute Myocardial Infarction (AMI) and Acute Ischemia (AI) such as acute angina and Chronic Ischemia (CI) such as chronic stable angina, and also determine the cell cycle status of these cells. Method: Patients with AMI and AI were recruited in the ICCU, and patients with CI in the departments of cardiology and cardiovascular surgery. The quantification of cellular subpopulations was made by cytofluorometry with a FACS caliburcyto fluorometry (Becton Dickinson) with specific FITC-labeled anti human monoclonal antibodies against CD34, CD133, CD117, CD48, CXCR4, SDF-1 and Ki67 (Becton Dickinson). Serum concentration of IL-6 and IL-8 were determined by a sequential solid phase chemiluminescent assay performed in a SIEMENS IMMULITE 1000 Analyzer. Statistical analysis was made with the SPSS version 20.0 for Windows. A p value 3/ml) than that in AI (9.2 ± 1.3 × 103/ml) and CI (6.6 ± 1.1 × 103/ml) patients (p p = 0.22 to 0.39), but interestingly in AMI and AI patients, cells were CXCR4+ in almost half of these mobilized cells, although the proportion was significantly higher in AMI patients (46.8% ± 7.1% to 55.7% ± 6.3% vs 23% ± 1.6% to 28.4% ± 2.1%, p = 0.03 to 0.05). A similar behavior was observed with the Ki67 antibody (29.9% ± 2.1% to 36.1% ± 6.3% vs 10% ± 1.2% to 24% ± 1.1%, p = 0.001 to 0.05). Bivariate analysis of the results showed a significant correlation of the cell proportion in AMI but not in AI and CI patients (p = 0.001 to 0.05;0.12 to 0.87 and 0.17 to 0.92 respectively). The amount of myocardial tissue infarcted did not show any correlation with the amount of cellular subpopulations mobilized to peripheral blood (r = 0.10 to 0.20;p = 0.21 to 0.64) from the bone marrow. Conclusion: The proportion of cellular subpopulations with regenerative potential mobilized to circulation during an event of Acute Myocardial Infarction is significantly higher than during an event of acute angina and chronic stable angina, with a significant proportion of mobilized cells that expressed CXCR4, most of which were already in some of the cell cycle phases.

墨西哥化学集团执行生态设计(DFE)

本文总结了一家墨西哥企业在化学品部门研发领域执行生态设计(DfE)的经验.DfE是一种可持续发展战略.它可以被用于检测潜在的环境风险,开发新产品和新工艺.DfE手册一出版,就分几个步骤循序渐进地开始执行.希望利益相关者采用DfE是出于信念而不是义务.因此,十分强调教育和机遇的确认.在项目的最后阶段,选择了两个正在开展的技术项目进行分析:一个尚处于试验阶段,另一个已经处于商业阶段.

墨西哥化学集团执行生态设计(DFE)

本文总结了一家墨西哥企业在化学品部门研发领域执行生态设计(DfE)的经验.DfE是一种可持续发展战略.它可以被用于检测潜在的环境风险,开发新产品和新工艺.DfE手册一出版,就分几个步骤循序渐进地开始执行.希望利益相关者采用DfE是出于信念而不是义务.因此,十分强调教育和机遇的确认.在项目的最后阶段,选择了两个正在开展的技术项目进行分析:一个尚处于试验阶段,另一个已经处于商业阶段.

添加不同粒径及比例的纤维素对鱼糜制品凝胶特性的影响

该实验通过研究添加不同粒径和不同比例的纤维素对鱼丸、鱼肠和鱼糕的白度、持水力、凝胶强度、全质构分析、水分分布和感官品质的影响来确定最佳添加粒径及比例。研究发现,纤维素的添加能有效提高3种常见鱼糜制品的白度、持水力、凝胶强度和质构特性,降低自由水的含量。鱼丸、鱼肠和鱼糕的持水力、凝胶强度、硬度、咀嚼性和不易流动水的比例会随着纤维素粒径的增大而增大,随着添加比例的增大而呈现先增大后减小的趋势。研究发现,纤维素粒径为200μm,添加比例为2%(质量分数)时,加工的鱼糜制品会更受消费者青睐。综合考虑,在添加纤维素粒径为200μm,添加比例在2%(质量分数)时,能最大程度地提高3种常见鱼糜制品的品质,分别能将鱼丸、鱼肠和鱼糕的持水力提高14.5%、22.1%和8.9%;凝胶强度提高121.9%、108.7%和65.5%;硬度提高97.5%、107.0%和158.8%;不易流动水比例提高0.8%、1.7%和1.7%。

Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(MASLD)risk stratification.Our ability to identify patients with MASLD with advanced fibrosis and at higher risk for adverse outcomes is still limited.Incorporating novel biomarkers could represent a meaningful improvement to current risk predictors.With this aim,omics technologies have revolutionized the process of MASLD biomarker discovery over the past decades.While the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and utility.If we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in MASLD clinical practice is rigorous and,therefore,not easily accomplished.This article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving MASLD biomarker research.

基于多光谱方法和计算模拟的细胞色素CYP1A2与阿奇霉素的结合机制研究

为了解阿奇霉素(AZI)在模拟的人体环境中与CYP1A2的结合情况,探索AZI在人体内的转化机制,本论文使用分子对接、分子动力学模拟、荧光光谱、紫外分光光度法、傅立叶变换红外光谱、圆二色光谱等多种实验方法,阐明AZI与CYP1A2之间的相互作用机制。分子对接结果表明AZI与CYP1A2的结合方式是半包裹并且以疏水作用力相结合。分子动力学模拟结果表明,CYP1A2-AZI复合物的均方根偏差(RMSD)值增大;均方根波动(RMSF)值表明复合物体系柔性较大;回旋半径(Rg)值表明蛋白质特定区域的结构松散。荧光猝灭光谱实验表明,CYP1A2与AZI是以静态猝灭机制结合在一起。热力学参数表明AZI与CYP1A2之间的主导作用力为疏水作用力。时间分辨光谱表明AZI对CYP1A2的机制为静态猝灭。紫外光谱实验表明AZI与CYP1A2反应生成了复合物。红外光谱实验结果表明CYP1A2的二级结构含量发生了改变。圆二色光谱证实AZI对CYP1A2的二级结构产生影响。

Natural variation in maize gene ZmSBR1 confers seedling resistance to Fusarium verticillioides

Maize seedling blight caused by Fusarium verticillioides is a widely occurring maize disease,but the genetics and mechanisms of resistance are not well understood.In this study,GWAS performed by MLM and 3VmrMLM identified 40 and 20 QTNs,associated with seedling blight resistance.These methods identified 49 and 36 genes,respectively.Functional verification of candidate gene ZmSBR1 identified by both methods showed that the resistance of a mutant line to seedling blight decreased by 0.37 grade points after inoculation with F.verticillioides,compared with the WT.The length of the stem rot lesion caused by F.verticillioides increased by 86%in mutant seedlings,and the relative length of the adult plant stalk rot increased by 35%in mutant plants compared to the wild type after inoculation with Fusarium graminearum.Transcriptome analysis showed that expression of defense-related genes after inoculation was down-regulated in the mutant compared to the wild type,synthesis of secondary metabolites associated with resistance was reduced,and the immune response triggered by PAMP decreased,resulting in decreased resistance of mutant maize seedlings.Candidate gene association analysis showed that most maize inbred lines carried the susceptible haplotype.A functional PCR marker was developed.The results demonstrated that ZmSBR1 conferred resistance to multiple Fusarium diseases at the seedling and adult growth stages and had important application value in breeding.

印象派女艺术家的成长,身份确认和价值再发现——以贝尔特·莫里索为例

贝尔特·莫里索是印象派女艺术家,但由于种种原因,一直都被淹没在艺术史中。本文将从莫里索的艺术成长之路、莫里索对女性题材的表达与艺术同行对此的评价、19世纪艺术展览和经销商对莫里索的推动以及艺术史学家对莫里索价值的再发现等章节度去探讨她是如何在当时以男权为主的艺术世界获得一席之地,却在去世时遭到艺术家身份的质疑,后来又被艺术史学家再次发现其价值的过程。

Linking 24-h Movement Behavior Guidelines to Cognitive Difficulties,Internalizing and Externalizing Problems in Preterm Youth

Background:Given the heightened risk of developmental challenges associated with preterm birth,it is crucial to explore interventions that may ameliorate potential adverse outcomes.This study aimed to examine whether meeting the 24-h movement behavior(24-HMB)guidelines,which include recommendations on physical activity(PA),screen time(ST),and sleep(SL),is related to indicators of cognitive difficulties,internalizing problems(e.g.,depression and anxiety),and externalizing problems(e.g.,difficulties in making friends and arguing)in a sample of preterm youth(children and adolescents born preterm).Methods:In this cross-sectional study,data from 3410 preterm youth(aged 6 to 17 years)were included for data analyses.Multivariable logistic regression was used to investigate associations between meeting the 24-HMB guidelines and the above-mentioned health outcomes,while controlling for sociodemographic and health-related factors.Results:The prevalence of meeting 24-HMB guidelines varied across independent and integrated components of the 24-HMB guidelines.Meeting the ST guideline alone(p<0.05)and integrated guidelines(i.e.,ST+SL and ST+SL+PA)were associated with fewer cognitive difficulties and reduced internalizing and externalizing problems(p<0.05).Specifically,meeting the SL guideline alone and integrated guidelines(i.e.,SL+ST)were associated with lower odds of depression and anxiety(p<0.01).Additionally,meeting independent,and integrated(PA and/or ST)guidelines were associated with less pronounced difficulties in making friends and arguing(p<0.05).Meeting 24-HMB guidelines in an isolated and integrated manner are linked to better cognitive performance and fewer internalizing and externalizing problems in preterm youth.Conclusion:Results suggest that advocating for the implementation of the 24-HMB guidelines may reduce cognitive challenges and behavioral issues,which is of high relevance for improving public health.Future longitudinal studies in preterm youth should investigate how modifying specific 24-HMB behaviors,especially ST,influence cognitive difficulties,internalizing and externalizing problems in this vulnerable population.

Boll weevils in dry bolls:is there a performance disadvantage?

Background Anthonomus grandis grandis is the main cotton pest in the Americas,with the potential to become a pest in other continents.The insect uses the plant's reproductive organs for feeding,oviposition,and survival strategies in the off-season,sheltering in dry bolls.This study aimed to know the reproductive potential,feeding,longevity,and morphometric characteristics of boll weevils from dry bolls,squares,and traps.Adults were obtained from infested squares,dry bolls,and traps installed in cotton fields and the Caatinga area.Thirty weevil pairs were maintained in the laboratory to assess the oviposition,feeding holes,longevity,and morphometric measurements of the parental and F_(1) generations.Results In the parental generation,boll weevils from traps(the Caatinga area and cotton cultivation)showed greater reproductive potential.Boll weevils from squares and the Caatinga area showed greater feeding activity compared with those from cotton cultivation.Greater rostrum length,thorax+abdomen length,and abdomen width were observed in boll weevils from cotton cultivation and dry bolls.The origin of boll weevils parental generation did not affect progeny emergence time.The F_(1) generation of boll weevils showed significant differences in average longevity depending on the origin of different microhabitats.Furthermore,differences in rostrum lengths were observed,with the boll weevils coming from traps installed in cotton cultivation,the Caatinga area,and dry bolls being the largest.Regarding thorax+abdomen length and abdomen width,the highest values were observed in those from the Caatinga area and cotton cultivation.Conclusion It was proven that dry bolls did not affect the reproductive,feeding,and longevity performance of boll weevils,enabling better insect fitness(reproduction and size)in relation to those coming from squares.The use of dry bolls as off-season shelter is an important survival strategy for the boll weevil.

Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease

This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit.

Influence of variables related to soil weathering on the geomechanical performance of tropical soils

This paper presents an experimental and analytical investigation of the influence of variables related to soil weathering on the geomechanical performance of sand-silt mixtures containing lateritic soils,i.e.intensely weathered tropical soils with the influence of interparticle bonding.The sand-silt mixtures containing different relative proportions between uniform sand and lateritic soil were produced,and geomechanical soil characterization tests were performed.Based on the results,a transition from a primarily coarse-to a fine-grained prevailing soil structure was found to cause considerable impact on the geomechanical performance of these soils,as evidenced by design variables related to soil mineralogy and size distribution characteristics.Specifically,fines contents of both individual soil particles and soil aggregations were found to correlate with experimental results,while the relative proportion between sesquioxides(aluminum,and iron oxides),and silica,i.e.sesquioxide-silica ratios(SSR^(-1)),facilitated estimates concerning changes in geomechanical performance.Finally,the application of the sandsilt mixtures containing lateritic soil on soil walls reinforced with polymeric strips was also evaluated,further emphasizing the potential advantages of adopting variables related to soil weathering on design guidelines concerning tropical soils.

Relationships between Features of EmergingAdulthood, Situated Decisions toward PhysicalActivity, and Physical Activity among CollegeStudents: The Moderating Role of ExerciseIntensity Tolerance

A significant portion of emerging adults do not achieve recommended levels of physical activity (PA). Previous studies observedassociations between features of emerging adulthood and PA levels, while the potential psychological mechanisms that mightexplain this phenomenon are not fully understood. In this context, there is some evidence that situated decisions towardphysical activity (SDPA) and exercise-intensity tolerance might influence PA level. To provide empirical support for thisassumption, the current study investigated whether (i) features of emerging adulthood are linked to SDPA, which, in turn,might affect PA engagement;(ii) exercise-intensity tolerance moderate the relationship between SDPA and PA level;and (iii)SDPA is a mediator of the relationship between features of emerging adulthood and PA levels under the prerequisite thatexercise-intensity tolerance moderates the link between SDPA and PA engagement. In this study a group of 1,706 Chinesecollege students was recruited and asked to complete a set of questionnaires assessing their SDPA, PA levels, exercise-intensitytolerance, and features associated with emerging adulthood, namely Self-exploration, Instability, and Possibility. Our resultsindicated that SDPA positively predicted PA levels and this relationship became stronger when exercise-intensity tolerance wasused as a moderator. Furthermore, it was observed that individuals with a higher level of Instability and a lower level ofPossibility during emerging adulthood exhibited a lower level of SDPA. Taken together, the results of our study providefurther insights on a potential psychological mechanism linking features of emerging adulthood and physical activity.

从《少女与独角兽》看中世纪晚期新贵族的女性教育

女性形象的定义服务于女性教育。挂毯《少女与独角兽》的淑女形象反映了中世纪新贵族的理想女性标准,这与中世纪女性教育的原则相一致,即使她们成为完美的妻子。在这样的女性期待下,挂毯的用意远远超出感官寓言画或仅供贵族表达高雅这一相当笼统的主题,作品表明了女性教育特有的一些思想和要求。这种教育的有效性,从维斯特家族的女性命运可以看出。因此,该文将中世纪的文学作品与挂毯中少女形象的道德寓意对比解读,同时联系维斯特家族的女性命运来探究新贵族阶层的女性教育,最终的解释都指向了女性教育的思想内涵与要求。

完善我国海事调查制度的思考——基于海事调查报告及责任认定书的可诉性分析

通过梳理海事调查报告及责任认定书的法律属性,对其可诉与不可诉的法律基础进行分析,基于行政法公平、正义原则,分析海事调查报告对行政相对人产生的影响,针对相关救济途径和手段缺失等问题,提出建议,以期澄清理论认识,助益实务。

多种园林植物降雨截流服务功能的时效性研究

为探讨不同乔灌搭配园林植物的降雨截流能力,对16种乔灌搭配1年内22批次有效降水事件下的截流数据进行分析。结果表明,以杜英+杜鹃、杜英+山茶、香樟+海桐、香樟+山茶、樱花+檵木为组合的植物降雨截流能力在时长上表现最好;在植物降雨截流服务功能的有效时间内,以山茶作为灌木层的乔灌搭配具有明显优势。在降水事件进行到后期时,以香樟+山茶、樱花+檵木为乔灌搭配的植物组合的林冠截流能力呈现缓慢上升的趋势。综上所述,杜英+山茶与香樟+山茶的植物搭配在应对城市内涝时具有显著优势,樱花+檵木、樱花+山茶在应对城市内涝时具有较大优势。

Can rainfall seasonality trigger soil water repellency in a tropical riparian forest?

Though riparian areas generally have a shallow water table and higher soil moisture compared to up slope areas,climatic seasonality may trigger water repellency in tropical riparian forests,which,if persistent,could negatively affect essential ecosystem functions related to water resources protection such as reduced overland-flow,sediment transport,and nutrient filtration.The objective of this study was to answer the following:can tropical riparian forests develop water repellency?If so,does water repellency affect infiltration on a seasonal basis?For this,water repellency and infiltration were measured in a grid of 72points during a dry and a wet month of a tropical riparian forest with a shallow water table in a region with highly marked climatic seasonality.Water repellency and infiltration were significantly different between the wet and dry months.Water repellency affected negatively infiltration in the dry month,its effect in the wet month was insignificant.As a result,a higher infiltration capacity was observed over the wet period.Previous research has claimed that the development and persistence of repellency in soils could promote other hydrological processes such as overland flow.The findings shown here demonstrate that such phenomenon does not persist longer than the dry season.

Control of tendon cell fate in the embryonic limb: A molecular perspective

The molecular cascade underlying tendon formation starts when progenitor cells begin to express the Scleraxis(Scx)gene.Scx knockout mice develop some but not all tendons,suggesting that additional factors are necessary for tendon commitment,maintenance,and differentiation.Other transcription factors,such as Mohawk(Mkx)or early growth response(Egr),maintain Scx expression and extracellular matrix formation during fibrillogenesis.The inhibition of wingless and int-related protein signaling is necessary and sufficient to induce the expression of Scx.Once the commitment of tenogenic lineage occurs,transforming growth factor-beta(TGFβ)induces the Scx gene expression,becoming involved in the maintenance of tendon cell fate.From this point of view,we discussed two phases of the tenogenic process during limb development:dependent and independent of mechanical forces.Finally,we highlight the importance of understanding embryonic tendon development to improve therapeutic strategies in regenerative medicines for tendons.

房屋白蚁防治档案信息资源的开发利用探析

白蚁防治档案信息是白蚁防治过程的历史记录,是白蚁防治全过程的真实反映,白蚁防治档案对白蚁防治规划、施工、管理发挥着巨大的作用。目前对于白蚁防治档案信息资源的开发利用还存在较大问题,主要体现在被动式服务、浅层次利用、信息化滞后、共享程度低等方面。该文详细分析了出现这些问题的原因,提出了加强白蚁防治档案开发利用的科学措施,可供相关从业人员参考。