Among a variety of adaptive designs, stage-wise design, especially, two-stage design is an important one because patient responses are not available immediately but are available in batches or intermittently in some s...Among a variety of adaptive designs, stage-wise design, especially, two-stage design is an important one because patient responses are not available immediately but are available in batches or intermittently in some situations. In this paper, by Bayesian method, the general formula of asymptotical optimal worth is given, meanwhile the length of some optimal designs at first stage concerning two-stage trials in several important cases has been obtained.展开更多
基金the National Natural Science Foundation of China (Grant No.10271001).
文摘Among a variety of adaptive designs, stage-wise design, especially, two-stage design is an important one because patient responses are not available immediately but are available in batches or intermittently in some situations. In this paper, by Bayesian method, the general formula of asymptotical optimal worth is given, meanwhile the length of some optimal designs at first stage concerning two-stage trials in several important cases has been obtained.
