This study was undertaken to investigate the regulatory effect of Resveratrol (Res) on the proliferation and apop- tosis of synoviocytes of patients with rheumatoid arthritis (RA), as the proliferation of synoviocytes...This study was undertaken to investigate the regulatory effect of Resveratrol (Res) on the proliferation and apop- tosis of synoviocytes of patients with rheumatoid arthritis (RA), as the proliferation of synoviocytes of patients was deter- mined by MTT chromatometry and the apoptosis of these cells was assayed with TUNEL flow cytometry. It was found in this experiment that the degree of cell proliferation of the Res-treated group with dosages of 50-400 μM was significantly reduced in comparison with that of the control group, but percentage of the apoptotic cells demonstrated with TUNEL labeling was el- evated under treatment with Res at the same dosages in a concentration-dependent manner. The difference between the Res- treated group and the control group was quite significant ( P < 0.01). It is concluded that Res shows a potent anti-prolifera- tive effect on synoviocytes of patients with RA with induction of cell apoptosis, and it is likely a valuable candidate for the chemotherapy and management of patients with RA.展开更多
文摘This study was undertaken to investigate the regulatory effect of Resveratrol (Res) on the proliferation and apop- tosis of synoviocytes of patients with rheumatoid arthritis (RA), as the proliferation of synoviocytes of patients was deter- mined by MTT chromatometry and the apoptosis of these cells was assayed with TUNEL flow cytometry. It was found in this experiment that the degree of cell proliferation of the Res-treated group with dosages of 50-400 μM was significantly reduced in comparison with that of the control group, but percentage of the apoptotic cells demonstrated with TUNEL labeling was el- evated under treatment with Res at the same dosages in a concentration-dependent manner. The difference between the Res- treated group and the control group was quite significant ( P < 0.01). It is concluded that Res shows a potent anti-prolifera- tive effect on synoviocytes of patients with RA with induction of cell apoptosis, and it is likely a valuable candidate for the chemotherapy and management of patients with RA.
