Cholangiocarcinoma(CCA)is a highly aggressive biliary tree malignancy with intrahepatic and extra-hepatic sub-types that differ in molecular pathogeneses,epidemiology,clinical manifestations,treatment,and prognosis.Th...Cholangiocarcinoma(CCA)is a highly aggressive biliary tree malignancy with intrahepatic and extra-hepatic sub-types that differ in molecular pathogeneses,epidemiology,clinical manifestations,treatment,and prognosis.The over-all prognosis and patient survival remains poor because of lack of early diagnosis and effective treatments.Preclini-cal in vivo studies have become increasingly paramount as they are helpful not only for the study of the fundamental molecular mechanisms of CCA but also for developing novel and effective therapeutic approaches of this fatal cancer.Recent advancements in cell and molecular biology have made it possible to mimic the pathogenicity of human CCA in chemical-mechanical,infection-induced inflammatory,implantation,and genetically engineered animal models.This review is intended to help investigators understand the particular strengths and weaknesses of the currently used in vivo animal models of human CCA and their related mod-eling techniques to aid in the selection of the one that is the best for their research needs.展开更多
基金This work was supported by the Outstanding Young Talents Program in Higher Education Institutions of Anhui Province(No.gxfx2017066)the 512 Talent Cultivation Plan of Bengbu Medical College(No.by51202208)+2 种基金the internal grants from both Distinguished Young Scholars Science Foundation(No.2019byyfyjq02)General New Technology Project(No.2020144)of the First Affiliated Hospital of Bengbu Medical CollegeBaoan Ji is supported by the NCI-funded Mayo Clinic SPORE in Hepatobiliary Cancer(P50 CA210964).
文摘Cholangiocarcinoma(CCA)is a highly aggressive biliary tree malignancy with intrahepatic and extra-hepatic sub-types that differ in molecular pathogeneses,epidemiology,clinical manifestations,treatment,and prognosis.The over-all prognosis and patient survival remains poor because of lack of early diagnosis and effective treatments.Preclini-cal in vivo studies have become increasingly paramount as they are helpful not only for the study of the fundamental molecular mechanisms of CCA but also for developing novel and effective therapeutic approaches of this fatal cancer.Recent advancements in cell and molecular biology have made it possible to mimic the pathogenicity of human CCA in chemical-mechanical,infection-induced inflammatory,implantation,and genetically engineered animal models.This review is intended to help investigators understand the particular strengths and weaknesses of the currently used in vivo animal models of human CCA and their related mod-eling techniques to aid in the selection of the one that is the best for their research needs.
