This study investigated the use of a product based on yacon (PBY) in microbiological, physical-chemical and intestinal characteristics of Wistar rats artificially constipated with Loperamide®. Thirty-two rats ...This study investigated the use of a product based on yacon (PBY) in microbiological, physical-chemical and intestinal characteristics of Wistar rats artificially constipated with Loperamide®. Thirty-two rats were divided into four groups: Control (C), Constipated Control (CC), PBY (not constipated) and Constipated PBY (PBYC). The dosage of 0.14 g of FOS+ inulin/kg was tested. Microbiota, pH and faeces characteristics of faeces and caecal contents were evaluated. Caecal weight, morphometry of caecal villi and the concentration of short-chain fatty acids were determined. Higher caecal weight was identified in the PBYC animals as well as higher width, height and depth of cripts. The PBY group showed the highest (p < 0.05) concentration of butyrate (93.2 ± 65.5 mmol/L). The supplementation with PBY positively altered the intestine epithelial tissue in constipated animals, keeping the integrity of the caecum crypts.展开更多
The importance of maintaining a healthy intestinal microbiota in the health of the host has been increasingly clarified. This microbiota may appear unbalanced in diseases such as colitis, diarrhea, irritable bowel syn...The importance of maintaining a healthy intestinal microbiota in the health of the host has been increasingly clarified. This microbiota may appear unbalanced in diseases such as colitis, diarrhea, irritable bowel syndrome and constipation. To rebalance the microbiota and improve the symptoms of constipation, it is recommended to intake prebiotics, probiotics and symbiotics, which works in the modulation of a healthy intestinal microbiota and favors the production of short-chain fatty acids that have a positive effect on intestinal transit. In addition, some studies indicate that there is a relation between the brain and the intestine that influences the behavior of individuals with intestinal dysbiosis. Thus, the reestablishment of the eubiosis in constipated patients through the functional compounds (prebiotics, probiotics and symbiotics) has been showing promising results regarding the modulation of constipation and improvement of the clinical picture. This review will emphasize the relation of prebiotics, probiotics and symbiotics in the modulation of intestinal constipation. New food sources of these compounds should be evaluated for their efficacy, dose and effect to establish a proper management.展开更多
The article reflects on the “philosophy of dialogue” of Martín Buber for the analysis of the relationship of women who live with arterial hypertension. With the theoretical proposal of Buber, considering the so...The article reflects on the “philosophy of dialogue” of Martín Buber for the analysis of the relationship of women who live with arterial hypertension. With the theoretical proposal of Buber, considering the social context from the world view of the disease, this leads to relationships of suffering and anguish, but with dialogue among the people who live with this disease it is observed in specific cases of chronic disease. Likewise, the panorama of the problem is the interaction between the social being and the disease, in order to generate a dialogue between the disease and the women who live daily this condition.展开更多
基金supported by the National Council of Scientific and Technological Development—CNPqthe Foundation for Research Support of the State of Minas Gerais—FAPEMIG.
文摘This study investigated the use of a product based on yacon (PBY) in microbiological, physical-chemical and intestinal characteristics of Wistar rats artificially constipated with Loperamide®. Thirty-two rats were divided into four groups: Control (C), Constipated Control (CC), PBY (not constipated) and Constipated PBY (PBYC). The dosage of 0.14 g of FOS+ inulin/kg was tested. Microbiota, pH and faeces characteristics of faeces and caecal contents were evaluated. Caecal weight, morphometry of caecal villi and the concentration of short-chain fatty acids were determined. Higher caecal weight was identified in the PBYC animals as well as higher width, height and depth of cripts. The PBY group showed the highest (p < 0.05) concentration of butyrate (93.2 ± 65.5 mmol/L). The supplementation with PBY positively altered the intestine epithelial tissue in constipated animals, keeping the integrity of the caecum crypts.
文摘The importance of maintaining a healthy intestinal microbiota in the health of the host has been increasingly clarified. This microbiota may appear unbalanced in diseases such as colitis, diarrhea, irritable bowel syndrome and constipation. To rebalance the microbiota and improve the symptoms of constipation, it is recommended to intake prebiotics, probiotics and symbiotics, which works in the modulation of a healthy intestinal microbiota and favors the production of short-chain fatty acids that have a positive effect on intestinal transit. In addition, some studies indicate that there is a relation between the brain and the intestine that influences the behavior of individuals with intestinal dysbiosis. Thus, the reestablishment of the eubiosis in constipated patients through the functional compounds (prebiotics, probiotics and symbiotics) has been showing promising results regarding the modulation of constipation and improvement of the clinical picture. This review will emphasize the relation of prebiotics, probiotics and symbiotics in the modulation of intestinal constipation. New food sources of these compounds should be evaluated for their efficacy, dose and effect to establish a proper management.
文摘The article reflects on the “philosophy of dialogue” of Martín Buber for the analysis of the relationship of women who live with arterial hypertension. With the theoretical proposal of Buber, considering the social context from the world view of the disease, this leads to relationships of suffering and anguish, but with dialogue among the people who live with this disease it is observed in specific cases of chronic disease. Likewise, the panorama of the problem is the interaction between the social being and the disease, in order to generate a dialogue between the disease and the women who live daily this condition.
