Activin plays an important role in numerous physiological processes such as cell differentiation and remodeling, regeneration and repair of tissues from various organs, angiogenesis, morphogenesis of glandular organs,...Activin plays an important role in numerous physiological processes such as cell differentiation and remodeling, regeneration and repair of tissues from various organs, angiogenesis, morphogenesis of glandular organs, pluripotency and differentiation of stem cells, cell adhesion and apoptosis. It participates in reproductive processes like embryogenesis, in the expression of Follicle Stimulating Hormone and Luteinizing Hormone and maturation of ovarian follicles and therefore has application in the area of reproduction of vertebrates. Given the economic importance of activin, we develop an efficient and economical method for the production of recombinant human activin A (rACT), using as expression system the yeast Pichia pastoris. rACT showed biological activity as it induced, on submicromolar dose, the increase of ovarian mass and the ovulation process in a mammal model.展开更多
Breast weight is one of the most economically important traits in the poultry industry, but direct selection for weight is expensive. The use of ultrasonography enables in vivo measurements of the broiler’s breast mu...Breast weight is one of the most economically important traits in the poultry industry, but direct selection for weight is expensive. The use of ultrasonography enables in vivo measurements of the broiler’s breast muscle size, which may be much more feasible for broiler selection. Previous studies of broilers concluded that ultrasound of the breast muscle is feasible and favorable for meat production. According to previously obtained genetic parameters, breast weight could be efficiently improved by ultrasound of the breast muscle. The use of ultrasonography for the indirect selection of breast weight does not affect the body composition or meat quality of broilers, despite the meat’s paleness and shear force;therefore, the use of ultrasound as a selection criterion might be a useful monitoring tool. Studies on the utilization of ultrasound in broiler breeding programs allow a better understanding of the relationship between traits of economic interest and the establishment of the selection schemes.展开更多
It is reported that neurodegeneration is a process that is implicated in both neuropharmacological disorders and brain aging [1].Research has shown that natural products have a wide range of pharmacological and biolog...It is reported that neurodegeneration is a process that is implicated in both neuropharmacological disorders and brain aging [1].Research has shown that natural products have a wide range of pharmacological and biological activities, some of which have the potential for use in the treatment of Parkinson’s disease (PD)[1].展开更多
文摘Activin plays an important role in numerous physiological processes such as cell differentiation and remodeling, regeneration and repair of tissues from various organs, angiogenesis, morphogenesis of glandular organs, pluripotency and differentiation of stem cells, cell adhesion and apoptosis. It participates in reproductive processes like embryogenesis, in the expression of Follicle Stimulating Hormone and Luteinizing Hormone and maturation of ovarian follicles and therefore has application in the area of reproduction of vertebrates. Given the economic importance of activin, we develop an efficient and economical method for the production of recombinant human activin A (rACT), using as expression system the yeast Pichia pastoris. rACT showed biological activity as it induced, on submicromolar dose, the increase of ovarian mass and the ovulation process in a mammal model.
文摘Breast weight is one of the most economically important traits in the poultry industry, but direct selection for weight is expensive. The use of ultrasonography enables in vivo measurements of the broiler’s breast muscle size, which may be much more feasible for broiler selection. Previous studies of broilers concluded that ultrasound of the breast muscle is feasible and favorable for meat production. According to previously obtained genetic parameters, breast weight could be efficiently improved by ultrasound of the breast muscle. The use of ultrasonography for the indirect selection of breast weight does not affect the body composition or meat quality of broilers, despite the meat’s paleness and shear force;therefore, the use of ultrasound as a selection criterion might be a useful monitoring tool. Studies on the utilization of ultrasound in broiler breeding programs allow a better understanding of the relationship between traits of economic interest and the establishment of the selection schemes.
基金supported by the following grants:FAPESP(Fundacao de AmparoàPesquisa do Estado de Sao Paulo)CNPq(Conselho Nacional de Desenvolvimento Científico e Tecnológico)+1 种基金CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nível Superior)FAPEMIG (Fundacao de AmparoàPesquisa do Estado de Minas Gerais)。
文摘It is reported that neurodegeneration is a process that is implicated in both neuropharmacological disorders and brain aging [1].Research has shown that natural products have a wide range of pharmacological and biological activities, some of which have the potential for use in the treatment of Parkinson’s disease (PD)[1].
