Gastric cancer remains one of the most common cancers worldwide and one of the leading cause for cancerrelated deaths. Gastric adenocarcinoma is a multifactorial disease that is genetically, cytologically and architec...Gastric cancer remains one of the most common cancers worldwide and one of the leading cause for cancerrelated deaths. Gastric adenocarcinoma is a multifactorial disease that is genetically, cytologically and architecturally more heterogeneous than other gastrointestinal carcinomas.The aberrant activation of the Wnt/β-catenin signaling pathway is involved in the development and progression of a significant proportion of gastric cancer cases. This review focuses on the participation of the Wnt/b-catenin pathway in gastric cancer by offering an analysis of the relevant literature published in this field. Indeed, it is discussed the role of key factors in Wnt/β-catenin signaling and their downstream effectors regulating processes involved in tumor initiation, tumor growth, metastasis and resistance to therapy. Available data indicate that constitutive Wnt signalling resulting from Helicobacter pylori infection and inactivation of Wnt inhibitors(mainly by inactivating mutations and promoter hypermethylation) play an important role in gastric cancer. Moreover, a number of recent studies confirmed CTNNB1 and APC as driver genes in gastric cancer. The identification of specific membrane, intracellular, and extracellular components of the Wnt pathway has revealed potential targets for gastric cancer therapy. High-throughput "omics" approaches will help in the search for Wnt pathway antagonist in the near future.展开更多
Tissue engineering has provided new treatment alternatives for tissue reconstruction. Advances in the tissue engineeringfield have resulted in mechanical support and biological substitutes to restore, maintain or impr...Tissue engineering has provided new treatment alternatives for tissue reconstruction. Advances in the tissue engineeringfield have resulted in mechanical support and biological substitutes to restore, maintain or improve tissue/organs structuresand functions. The application of tissue engineering technology in the vaginal reconstruction treatment can not onlyprovide mechanical requirements, but also offer tissue repairing as an alternative to traditional approaches. In this review, wediscuss recent advances in cell-based therapy in combination with scaffolds strategies that can potentially be adopted forgynaecological transplantation.展开更多
文摘Gastric cancer remains one of the most common cancers worldwide and one of the leading cause for cancerrelated deaths. Gastric adenocarcinoma is a multifactorial disease that is genetically, cytologically and architecturally more heterogeneous than other gastrointestinal carcinomas.The aberrant activation of the Wnt/β-catenin signaling pathway is involved in the development and progression of a significant proportion of gastric cancer cases. This review focuses on the participation of the Wnt/b-catenin pathway in gastric cancer by offering an analysis of the relevant literature published in this field. Indeed, it is discussed the role of key factors in Wnt/β-catenin signaling and their downstream effectors regulating processes involved in tumor initiation, tumor growth, metastasis and resistance to therapy. Available data indicate that constitutive Wnt signalling resulting from Helicobacter pylori infection and inactivation of Wnt inhibitors(mainly by inactivating mutations and promoter hypermethylation) play an important role in gastric cancer. Moreover, a number of recent studies confirmed CTNNB1 and APC as driver genes in gastric cancer. The identification of specific membrane, intracellular, and extracellular components of the Wnt pathway has revealed potential targets for gastric cancer therapy. High-throughput "omics" approaches will help in the search for Wnt pathway antagonist in the near future.
文摘Tissue engineering has provided new treatment alternatives for tissue reconstruction. Advances in the tissue engineeringfield have resulted in mechanical support and biological substitutes to restore, maintain or improve tissue/organs structuresand functions. The application of tissue engineering technology in the vaginal reconstruction treatment can not onlyprovide mechanical requirements, but also offer tissue repairing as an alternative to traditional approaches. In this review, wediscuss recent advances in cell-based therapy in combination with scaffolds strategies that can potentially be adopted forgynaecological transplantation.
