A commentary on the interplay of biomaterials and cell adhesion:new insights in bone tissue regeneration

This article navigates the relationship between biomaterials and osteogenic cell adhesion,highlighting the importance of mimicking the physiological response for bone tissue regeneration.Within this spirit is an initial description of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix,explaining the leading role of integrins and cadherins in cell adhesion,and the intracellular signaling pathways elicited.Additionally,there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating the native environment,taking advantage of these known specific signaling pathways.Thefinal remarks lay on the need for careful consideration of in-vitro and in-vivo complexities in biomaterial development.

2-卤-3-氨基-2-烯丙亚胺化合物的合成

由具有 2位氢的 3 氨基 2 烯丙亚胺与N 氯或N 溴琥珀酰亚胺以甲苯作溶剂在常温下反应 ,制备了一些未见文献报道的 2 氯和 2 溴 3 氨基 2 烯丙亚胺 ,化合物结构均经元素分析 ,1HNMR 。