Soil and water conservation is essential for sustaining food production and for preserving the environment in arid and semi arid lands （ASALs） where conditions for agriculture and other land use systems are often ha...Soil and water conservation is essential for sustaining food production and for preserving the environment in arid and semi arid lands （ASALs） where conditions for agriculture and other land use systems are often harsh and unpredictable. The ASALs of Algeria are an important source of a variety of non wood forest products like Stipa tenacissima L. plant （esparto grass）. This research was conducted to determine the effects of different low concentration （〈 I%） polyacrylaJnide, Stipa tenacissima L. fiber （esparto grass fibers） and its mixtures with the polymer at water retention in arid and semi arid soil. All samples are characterized by infrared spectroscopy, X-ray Diffractometry, thermal analysis TG DSC and scanning electron micrographs （SEM）. The results showed that polymer blend in soil could improve better soil physical proprieties decreased evaporation and increase water retention in arid soils compared with application of any other blend at the same concentration. The use of Polyacrylamide-Cellulose blend appears to promise for reducing the labor cost of irrigation at arid and semi-arid soils, and offers safe and environmentally friendly inexpensive materials. The importance of Polyacrylamide-Cellulose blends to alleviate poor physical properties and retain water in these arid regions to sustain plant growth.展开更多
In this work, we evaluated the quality of paracetamol generic tablets while seeking its two main impurities namely 4-para-aminophenol (4-AP) and 4-para-nitrophenol (4-NP) which have nephrotoxic and teratogenic propert...In this work, we evaluated the quality of paracetamol generic tablets while seeking its two main impurities namely 4-para-aminophenol (4-AP) and 4-para-nitrophenol (4-NP) which have nephrotoxic and teratogenic properties. Ninety-four (94) samples were collected at various levels of the medicine supply chain and illegal markets in Benin for quality control tests such as visual inspection, pharmacotechnical tests as mass variation, disintegration test, dissolution test, followed by HPLC UV-Vis identification and assay of paracetamol, 4-AP and 4-NP. The analytes were separated on C18 Lichrocart column (250 mm × 4.0 mm i.d, 5 μm);the mobile phase was MeOH:10 mM ammonium acetate buffer pH 6.8 (35:65) pumped at a flow rate of 1 ml/min. The detection was done at 245 nm. Analysis of our results shows that 77.7% of the samples did not comply with the visual inspection test requirements, 2.1% did not pass the mass variation test, 24.3% of the sample batches didn’t comply with the disintegration test requirements. In addition none of these uncomply batches passed the dissolution test, even if the identification test indicated that all samples contained paracetamol. None contained 4-NP (acceptance limit < 0.05% m/m;BP), while 3 of 94 samples contained 4-AP but within acceptance limit (4-AP < 0.1% m/m;BP). As for the paracetamol assay, 80.9% complied with the specifications of the pharmacopoeias taken as reference (90% - 110%;USP). Further, broader studies should be conducted according to the same rules of good practice for a more comprehensive analysis of the situation. Generally the quality control of paracetamol in most African countries, particularly in Benin, is based on pharmacotechnical tests and paracetamol assay. This work, in addition to the usual tests, showed the importance to search for paracetamol and other drugs’ impurities during their routine quality control.展开更多
文摘Soil and water conservation is essential for sustaining food production and for preserving the environment in arid and semi arid lands （ASALs） where conditions for agriculture and other land use systems are often harsh and unpredictable. The ASALs of Algeria are an important source of a variety of non wood forest products like Stipa tenacissima L. plant （esparto grass）. This research was conducted to determine the effects of different low concentration （〈 I%） polyacrylaJnide, Stipa tenacissima L. fiber （esparto grass fibers） and its mixtures with the polymer at water retention in arid and semi arid soil. All samples are characterized by infrared spectroscopy, X-ray Diffractometry, thermal analysis TG DSC and scanning electron micrographs （SEM）. The results showed that polymer blend in soil could improve better soil physical proprieties decreased evaporation and increase water retention in arid soils compared with application of any other blend at the same concentration. The use of Polyacrylamide-Cellulose blend appears to promise for reducing the labor cost of irrigation at arid and semi-arid soils, and offers safe and environmentally friendly inexpensive materials. The importance of Polyacrylamide-Cellulose blends to alleviate poor physical properties and retain water in these arid regions to sustain plant growth.
文摘In this work, we evaluated the quality of paracetamol generic tablets while seeking its two main impurities namely 4-para-aminophenol (4-AP) and 4-para-nitrophenol (4-NP) which have nephrotoxic and teratogenic properties. Ninety-four (94) samples were collected at various levels of the medicine supply chain and illegal markets in Benin for quality control tests such as visual inspection, pharmacotechnical tests as mass variation, disintegration test, dissolution test, followed by HPLC UV-Vis identification and assay of paracetamol, 4-AP and 4-NP. The analytes were separated on C18 Lichrocart column (250 mm × 4.0 mm i.d, 5 μm);the mobile phase was MeOH:10 mM ammonium acetate buffer pH 6.8 (35:65) pumped at a flow rate of 1 ml/min. The detection was done at 245 nm. Analysis of our results shows that 77.7% of the samples did not comply with the visual inspection test requirements, 2.1% did not pass the mass variation test, 24.3% of the sample batches didn’t comply with the disintegration test requirements. In addition none of these uncomply batches passed the dissolution test, even if the identification test indicated that all samples contained paracetamol. None contained 4-NP (acceptance limit < 0.05% m/m;BP), while 3 of 94 samples contained 4-AP but within acceptance limit (4-AP < 0.1% m/m;BP). As for the paracetamol assay, 80.9% complied with the specifications of the pharmacopoeias taken as reference (90% - 110%;USP). Further, broader studies should be conducted according to the same rules of good practice for a more comprehensive analysis of the situation. Generally the quality control of paracetamol in most African countries, particularly in Benin, is based on pharmacotechnical tests and paracetamol assay. This work, in addition to the usual tests, showed the importance to search for paracetamol and other drugs’ impurities during their routine quality control.
