The compleo(H_(2)O)4(3,3’-azpy)(3,3’-azpy)_(3)(PF_(6))_(2)}_(n)(3,3’-azpy=3,3’-azobispyridine)has been synthesized and characterized.The crystal(C_(40)H_(40)F_(12)CoN_(16)O_(4)P_(2),M r=1157.75)belongs to the tric...The compleo(H_(2)O)4(3,3’-azpy)(3,3’-azpy)_(3)(PF_(6))_(2)}_(n)(3,3’-azpy=3,3’-azobispyridine)has been synthesized and characterized.The crystal(C_(40)H_(40)F_(12)CoN_(16)O_(4)P_(2),M r=1157.75)belongs to the triclinic system,space groupP1with the following crystallographi c parameters:a=10.759(2),b=11.012(2),c=23.207(4)?;α=85.330(10),β=83.470(10),γ=69.770(10)°;V=2560.6(8)?3,D c=1.502g·cm-3,μ(Mo Kα)=0.498mm^(-1),F(000)=1178,Z=2,and final R_(1)=0.0469,w R_(2)=0.1053for observed reflections 5549(I>2.00σ(I)).The X-ray analysis reveals that cob alt?cation coordination environment is a distorted octahedral geometry,the Co^(2+)ion is coordinated by four oxygen ato ms of water in the equatorial plane,while the two nitrogen atoms of 3,3’-azpy occupy the axial positions.The complex forms a one-di mensional chain structure via3,3’-azpy bridging ligand.The one-dimension al chain forms three-dimensional network by hydrogen bonds andπ-πinter-actions.展开更多
Objective： Angiogennesis, the formation of new blood vessels from the existing vascular bed, is essential step for growth and invasion of primary rumor. Vascular endothelial growth factor （VEGF） is known to play cr...Objective： Angiogennesis, the formation of new blood vessels from the existing vascular bed, is essential step for growth and invasion of primary rumor. Vascular endothelial growth factor （VEGF） is known to play crucial role in tumor angiogenesis. In the present study, we investigate the expression of VEGF and VEGF-mRNA in the angiogennesis, metastasis and prognosis of lung cancer. Methods： The VEGF cellular distributions and expression in 38 specimens of patients with lung cancer were investigated with immunohistochemistry stain technology. The total RNAs in 38 tissues of lung cancer was measured, then the levels of VEGF-mRNA expression were analyzed by a reverse-transcription polymerase chain reaction （RT-PCR） assay. The levels of VEGF in sera of patients with lung cancer, benign lung diseases and healthy controls were detected through Enzyme linked immunosorbent assay （ELISA） method. Results： The VEGF positive stain was 76% in 38 cases of lung cancer specimens. The 89% rate of VEGF stain was found for clinical stage Ⅲ cases and 92% for stage Ⅳ lung cancers. The significantly higher expression of VEGF was evidenced in patients with lymph node metastasis （84%）, distant metastasis （90%）, and lung cancers with lower histological differentiation （89%）, respectively. The expression level of total RNA was significantly higher in patients with lung cancers than that in their paracancerons or distant lung tissues. The VEGF expressions were tightly correlated with total RNA concentration of lung carcinoma （ P 〈 0.01 ）. The predominant expressions of VEGF121 and VEGF165 gene fragments were found in lung cancer specimens by RT-PCR analysis. No significant difference of serum VEGF levels was detected between cases with lung cancer and patients with benign diseases. However, the VEGF level of cases with benign diseases was decreased significantly after patients with anti-inflammation medication. Conclusion： The present data suggested that the rumor tissue VEGF expression and VEGF-mRNA analysis in patients with lung cancer be a useful indicator for angiogenesis and metastasis of lung cancer.展开更多
Objective To evaluate whether Brugada’s wide QRS tachycardia criteria could be used to differentiate ventricular tachycardia(VT) from superventricular tachycardia(SVT) in patients with reexcitation syndrome or preexi...Objective To evaluate whether Brugada’s wide QRS tachycardia criteria could be used to differentiate ventricular tachycardia(VT) from superventricular tachycardia(SVT) in patients with reexcitation syndrome or preexisting bundle branch block(BBB). Methods 76 patients with preexcitation syndrome ,97 patients with CRBBB and 50 patients with CLBBB were enrolled .The wide QRS cmplex was evaluated whether to fulfill the criteria of VT or SVT with Brugada’s wide QRS tachycardia stepwise criteria .Toavoid the affects of some complications and drugs on the QRS morphology,the myocardial infartion ,obvious heart enlargement ,patients receiving antiarrhythmic drugs and congenitial heart disease were excluded.Result According to Brugada’s criteria ,all 76 cases(100%) with preexcitation syndrome fulfilled the diagnosis criteria of VT, while in all 147 patients with BBB only two(1.4%)fulfilled the criteria of VT. Conclusion The Brugada’s stepwise criteria could not be used in patients with preexcitation syndrome but could be used for the differentiation VT frome SVT in patients with preexisting bundle branch block.The results suggest that the criteria might be sensitive and specific in differentiation of wide QRS tachycardia between concentric and eccentric ventricular depolarization.展开更多
文摘The compleo(H_(2)O)4(3,3’-azpy)(3,3’-azpy)_(3)(PF_(6))_(2)}_(n)(3,3’-azpy=3,3’-azobispyridine)has been synthesized and characterized.The crystal(C_(40)H_(40)F_(12)CoN_(16)O_(4)P_(2),M r=1157.75)belongs to the triclinic system,space groupP1with the following crystallographi c parameters:a=10.759(2),b=11.012(2),c=23.207(4)?;α=85.330(10),β=83.470(10),γ=69.770(10)°;V=2560.6(8)?3,D c=1.502g·cm-3,μ(Mo Kα)=0.498mm^(-1),F(000)=1178,Z=2,and final R_(1)=0.0469,w R_(2)=0.1053for observed reflections 5549(I>2.00σ(I)).The X-ray analysis reveals that cob alt?cation coordination environment is a distorted octahedral geometry,the Co^(2+)ion is coordinated by four oxygen ato ms of water in the equatorial plane,while the two nitrogen atoms of 3,3’-azpy occupy the axial positions.The complex forms a one-di mensional chain structure via3,3’-azpy bridging ligand.The one-dimension al chain forms three-dimensional network by hydrogen bonds andπ-πinter-actions.
文摘Objective： Angiogennesis, the formation of new blood vessels from the existing vascular bed, is essential step for growth and invasion of primary rumor. Vascular endothelial growth factor （VEGF） is known to play crucial role in tumor angiogenesis. In the present study, we investigate the expression of VEGF and VEGF-mRNA in the angiogennesis, metastasis and prognosis of lung cancer. Methods： The VEGF cellular distributions and expression in 38 specimens of patients with lung cancer were investigated with immunohistochemistry stain technology. The total RNAs in 38 tissues of lung cancer was measured, then the levels of VEGF-mRNA expression were analyzed by a reverse-transcription polymerase chain reaction （RT-PCR） assay. The levels of VEGF in sera of patients with lung cancer, benign lung diseases and healthy controls were detected through Enzyme linked immunosorbent assay （ELISA） method. Results： The VEGF positive stain was 76% in 38 cases of lung cancer specimens. The 89% rate of VEGF stain was found for clinical stage Ⅲ cases and 92% for stage Ⅳ lung cancers. The significantly higher expression of VEGF was evidenced in patients with lymph node metastasis （84%）, distant metastasis （90%）, and lung cancers with lower histological differentiation （89%）, respectively. The expression level of total RNA was significantly higher in patients with lung cancers than that in their paracancerons or distant lung tissues. The VEGF expressions were tightly correlated with total RNA concentration of lung carcinoma （ P 〈 0.01 ）. The predominant expressions of VEGF121 and VEGF165 gene fragments were found in lung cancer specimens by RT-PCR analysis. No significant difference of serum VEGF levels was detected between cases with lung cancer and patients with benign diseases. However, the VEGF level of cases with benign diseases was decreased significantly after patients with anti-inflammation medication. Conclusion： The present data suggested that the rumor tissue VEGF expression and VEGF-mRNA analysis in patients with lung cancer be a useful indicator for angiogenesis and metastasis of lung cancer.
文摘Objective To evaluate whether Brugada’s wide QRS tachycardia criteria could be used to differentiate ventricular tachycardia(VT) from superventricular tachycardia(SVT) in patients with reexcitation syndrome or preexisting bundle branch block(BBB). Methods 76 patients with preexcitation syndrome ,97 patients with CRBBB and 50 patients with CLBBB were enrolled .The wide QRS cmplex was evaluated whether to fulfill the criteria of VT or SVT with Brugada’s wide QRS tachycardia stepwise criteria .Toavoid the affects of some complications and drugs on the QRS morphology,the myocardial infartion ,obvious heart enlargement ,patients receiving antiarrhythmic drugs and congenitial heart disease were excluded.Result According to Brugada’s criteria ,all 76 cases(100%) with preexcitation syndrome fulfilled the diagnosis criteria of VT, while in all 147 patients with BBB only two(1.4%)fulfilled the criteria of VT. Conclusion The Brugada’s stepwise criteria could not be used in patients with preexcitation syndrome but could be used for the differentiation VT frome SVT in patients with preexisting bundle branch block.The results suggest that the criteria might be sensitive and specific in differentiation of wide QRS tachycardia between concentric and eccentric ventricular depolarization.
