The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals,and the nitrile groups are versatile synthetic intermediates to other functionalized compounds.Herein,the asym...The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals,and the nitrile groups are versatile synthetic intermediates to other functionalized compounds.Herein,the asymmetric reduction ofα,β-unsaturated nitriles with water as a hydrogen source is reported.The reaction is catalyzed by the complex of[Ir(COD)Cl]_(2)and(R_(a),S)-Ph-Bn-SiPhox,and allows the preparation of useful enantioenriched chiral 3,3-disubstituted propionitriles with high optical purities in mild conditions.展开更多
基金grateful to the National Natural Science Foundation of China(Nos.21961045 and 22061048)the Basic Research Project of Chongqing Academy of Chinese Materia Medica(No.jbky20190028)+2 种基金the Fund Project of Yunnan Key Laboratory of Pharmacology for Natural Products(No.YKLPNP-K2303)Yunnan Provincial Key Laboratory Construction Plan Funding of UniversitiesYunnan Provincial Engineering Research Center Construction Plan Funding of Universities for their financial support.
文摘The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals,and the nitrile groups are versatile synthetic intermediates to other functionalized compounds.Herein,the asymmetric reduction ofα,β-unsaturated nitriles with water as a hydrogen source is reported.The reaction is catalyzed by the complex of[Ir(COD)Cl]_(2)and(R_(a),S)-Ph-Bn-SiPhox,and allows the preparation of useful enantioenriched chiral 3,3-disubstituted propionitriles with high optical purities in mild conditions.
