This review presents unique information rarely seen in a description of a politically extreme right wing terrorist. During the trial following the terror acts in Norway on July 22nd 2011, the author, a forensic psychi...This review presents unique information rarely seen in a description of a politically extreme right wing terrorist. During the trial following the terror acts in Norway on July 22nd 2011, the author, a forensic psychiatrist was at the time engaged by a national Norwegian newspaper to comment on the court proceedings. The author has later thoroughly gone through all available background material such as the terrorist’s childhood, relationship to his mother, childhood psychological evaluation, the interviews made by the forensic psychiatrists and information from the police documents. This information is shared in the review. The author also discusses how it was possible for two pairs of court appointed experienced forensic psychiatrists to arrive at completely different conclusions. One pair concluded with insanity due to Paranoid Schizophrenia and the second pair found no signs of psychotic disorder at all and concluded with Narcissistic Personality Disorder. The court found the terrorist capable to stand trial and sentenced him to 21 years in preventive detention with 10 years to be served before the possibility to apply for an appeal.展开更多
Intraperitoneal carcinomatosis(PC)may occur with several tumor entities.The prognosis of patients suffering from PC is usually poor.Present treatment depends on the cancer entity and includes systemic chemotherapy,rad...Intraperitoneal carcinomatosis(PC)may occur with several tumor entities.The prognosis of patients suffering from PC is usually poor.Present treatment depends on the cancer entity and includes systemic chemotherapy,radiation therapy,hormonal therapy and surgical resection.Only few patients may also benefit from hyperthermic intraperitoneal chemotherapy with a complete tumor remission.These therapies are often accompanied by severe systemic side-effects.One approach to reduce side effects is to target chemotherapeutic agents to the tumor with carrier devices.Promising experimental results have been achieved using drug-eluting beads(DEBs).A series of in vitro and in vitro experiments has been conducted to determine the suitability of their extravascular use.These encapsulation devices were able to harbor CYP2B1producing cells and to shield them from the hosts immune system when injected intratumorally.In this way ifosfamide-which is transformed into its active metabolites by CYP2B1-could be successfully targeted into pancreatic tumor growths.Furthermore DEBs can be used to target chemotherapeutics into the abdominal cavity for treatment of PC.If CYP2B1 producing cells are proven to be save for usage in man and if local toxic effects of chemotherapeutics can be controlled,DEBs will become promising tools in compartmentbased anticancer treatment.展开更多
文摘This review presents unique information rarely seen in a description of a politically extreme right wing terrorist. During the trial following the terror acts in Norway on July 22nd 2011, the author, a forensic psychiatrist was at the time engaged by a national Norwegian newspaper to comment on the court proceedings. The author has later thoroughly gone through all available background material such as the terrorist’s childhood, relationship to his mother, childhood psychological evaluation, the interviews made by the forensic psychiatrists and information from the police documents. This information is shared in the review. The author also discusses how it was possible for two pairs of court appointed experienced forensic psychiatrists to arrive at completely different conclusions. One pair concluded with insanity due to Paranoid Schizophrenia and the second pair found no signs of psychotic disorder at all and concluded with Narcissistic Personality Disorder. The court found the terrorist capable to stand trial and sentenced him to 21 years in preventive detention with 10 years to be served before the possibility to apply for an appeal.
文摘Intraperitoneal carcinomatosis(PC)may occur with several tumor entities.The prognosis of patients suffering from PC is usually poor.Present treatment depends on the cancer entity and includes systemic chemotherapy,radiation therapy,hormonal therapy and surgical resection.Only few patients may also benefit from hyperthermic intraperitoneal chemotherapy with a complete tumor remission.These therapies are often accompanied by severe systemic side-effects.One approach to reduce side effects is to target chemotherapeutic agents to the tumor with carrier devices.Promising experimental results have been achieved using drug-eluting beads(DEBs).A series of in vitro and in vitro experiments has been conducted to determine the suitability of their extravascular use.These encapsulation devices were able to harbor CYP2B1producing cells and to shield them from the hosts immune system when injected intratumorally.In this way ifosfamide-which is transformed into its active metabolites by CYP2B1-could be successfully targeted into pancreatic tumor growths.Furthermore DEBs can be used to target chemotherapeutics into the abdominal cavity for treatment of PC.If CYP2B1 producing cells are proven to be save for usage in man and if local toxic effects of chemotherapeutics can be controlled,DEBs will become promising tools in compartmentbased anticancer treatment.
