Traumatic brain injury(TBI) is a major cause of death and disability worldwide. Age-related TBI differences demonstrate the third peak of prevalence and incidence of TBI within the elderly population. This is due to t...Traumatic brain injury(TBI) is a major cause of death and disability worldwide. Age-related TBI differences demonstrate the third peak of prevalence and incidence of TBI within the elderly population. This is due to the elderly being at a higher risk of sustaining falls, which have been identified as the main cause(40–50%) of TBI.展开更多
Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate evolving tissue pathology.Immune cells respond to acute signals from damaged cells,initiate neuroinflammation,and drive the patho...Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate evolving tissue pathology.Immune cells respond to acute signals from damaged cells,initiate neuroinflammation,and drive the pathological consequences over time.Importantly,the mechanism(s)of injury,the location of the immune cells within the brain,and the animal species all contribute to immune cell behavior following traumatic brain injury.Understanding the signals that initiate neuroinflammation and the context in which they appear may be critical for understanding immune cell contributions to pathology and regeneration.Within this paper,we review a number of factors that could affect immune cell behavior acutely following traumatic brain injury.展开更多
Microglia,the resident innate immune cells of the central nervous system(CNS),play important roles in brain development,maintenance,and disease.As brain sentinels,microglia adopt a surveillant state in healthy tissue ...Microglia,the resident innate immune cells of the central nervous system(CNS),play important roles in brain development,maintenance,and disease.As brain sentinels,microglia adopt a surveillant state in healthy tissue characterized by a ramified scanning morphology that maintains CNS homeostasis and contributes to learningassociated synaptic plasticity.展开更多
基金supported by the National Institutes of Health Grants K99 NS116032 to RMR and R01 AG077541,RF1 NS110637,2RF1 NS094527,R01 NS110825,and R01 NS110635 to JW。
文摘Traumatic brain injury(TBI) is a major cause of death and disability worldwide. Age-related TBI differences demonstrate the third peak of prevalence and incidence of TBI within the elderly population. This is due to the elderly being at a higher risk of sustaining falls, which have been identified as the main cause(40–50%) of TBI.
基金supported by the Department of Veterans Affairs,USA(Merit Review I01-RX001097&I01-BX003748)
文摘Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate evolving tissue pathology.Immune cells respond to acute signals from damaged cells,initiate neuroinflammation,and drive the pathological consequences over time.Importantly,the mechanism(s)of injury,the location of the immune cells within the brain,and the animal species all contribute to immune cell behavior following traumatic brain injury.Understanding the signals that initiate neuroinflammation and the context in which they appear may be critical for understanding immune cell contributions to pathology and regeneration.Within this paper,we review a number of factors that could affect immune cell behavior acutely following traumatic brain injury.
文摘Microglia,the resident innate immune cells of the central nervous system(CNS),play important roles in brain development,maintenance,and disease.As brain sentinels,microglia adopt a surveillant state in healthy tissue characterized by a ramified scanning morphology that maintains CNS homeostasis and contributes to learningassociated synaptic plasticity.
