期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Diagnosis of deep vein thrombosis,and prevention of deep vein thrombosis recurrence and the post-thrombotic syndrome in the primary care medicine setting anno 2014 被引量:14
1
作者 Jan Jacques Michiels Janneke Maria Michiels +3 位作者 Wim Moossdorff Mildred Lao Hanny Maasland Gualtiero Palareti 《World Journal of Critical Care Medicine》 2015年第1期29-39,共11页
The requirement for a safe diagnostic strategy of deep vein thrombosis(DVT) should be based on an overall objective post incidence of venous thromboembolism(VTE) of less than 1% during 3 mo fol low-up. Compression ult... The requirement for a safe diagnostic strategy of deep vein thrombosis(DVT) should be based on an overall objective post incidence of venous thromboembolism(VTE) of less than 1% during 3 mo fol low-up. Compression ultrasonography(CUS) of the leg veins has a negative predictive value(NPV) of 97%-98% indicating the need of repeated CUS testing within one week. A negative ELISA VIDAS safely excludes DVT and VTE with a NPV between 99% and 100% at a low clinical score of zero. The combination of low clinical score and a less sensitive D-dimer test(Simplify) is not sensitive enough to exclude DVT and VTE in routine daily practice. From prospective clinical research studies it may be concluded that complete recanalization within 3-6 mo and no reflux is associated with a low or no risk of PTS obviating the need of MECS 6 mo after DVT. Partial and complete recanalization after 6 to more than 12 mo is usually complicated by reflux due to valve destruction and symptomatic PTS. Reflux seems to be a main determinant for PTS and DVT recurrence, the latter as a main contributing factor in worsening PTS. This hypothesis is supported by the relation between the persistent residual vein thrombosis(RVT = partial recanalization) and the risk of VTE recurrence in prospective studies. Absence of RVT at 3 mo postDVT and no reflux is predicted to be associated with no recurrence of DVT(1.2%) during follow-up obviating the need of wearing medical elastic stockings and anticoagulation at 6 mo post-DVT. The presence or absence of RVT but with reflux at or after 6 mo postDVT is associated with both symptomatic PTS and an increased risk of VTE recurrence in about one third in the post-DVT period after regular discontinuation of anticoagulant treatment. To test this hypothesis we designed a prospective DVT and postthrombotic syndrome(PTS) Bridging the Gap Study by addressing at least four unanswered questions in the treatment ofDVT and PTS.Which DVT patient has a clear indication for long-term compression stocking therapy to prevent PTS after the initial anticoagulant treatment in the acute phase of DVT?Is 6 mo the appropriate point in time to determine candidates at risk to develop DVT recurrence and PTS?Which high risk symptomatic PTS patients need extended anticoagulant treatment? 展开更多
关键词 Deep VENOUS THROMBOSIS ULTRASONOGRAPHY Post-thrombotic syndrome ELISA VIDAS D-DIMER Medical elastic stockings ANTICOAGULATION
下载PDF
以D-二聚体检测确定抗凝治疗持续时间 被引量:1
2
作者 Palareti G. Cosmi B. +1 位作者 Legnani C. 马超 《世界核心医学期刊文摘(心脏病学分册)》 2007年第4期4-5,共2页
背景:自发性静脉血栓栓塞患者应用口服抗凝剂的最佳持续时间尚不明确。D-二聚体水平检测可能在评估是否需要长期抗凝中具有作用。
关键词 二聚体 静脉血栓栓塞 持续时间 抗凝剂 近端 联合终点 拮抗剂 肺动脉栓塞 复发率 可由
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部