A nanometer porphyrin trimer was firstly synthesized with 1 ,3-dibromopropane as a bridge-linked agent and the fluorescence property and thermostability were studied. The results show that the fluorescence property an...A nanometer porphyrin trimer was firstly synthesized with 1 ,3-dibromopropane as a bridge-linked agent and the fluorescence property and thermostability were studied. The results show that the fluorescence property and thermostability of the trimer are different from those of monoporphyrin. The effects of the molecule structure on the optical property and the thermostability were also studied in detail.展开更多
MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that are involved in oncogenesis and show remarkable tissue specificity.miRNAs are approximately 22 nt non-coding RNAs, which regulate gene expression...MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that are involved in oncogenesis and show remarkable tissue specificity.miRNAs are approximately 22 nt non-coding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or messenger RNA (mRNA) degradation, thus affecting various cellular processes.Since the discovery of their fundamental mechanisms of action, the field of miRNAs has opened a new era in the understanding of small noncoding RNAs.Recent evidence has shown that miRNA controls cell growth, apoptosis, and differentiation.Cancer is a complex genetic disease caused by abnormalities in gene structure and expression, moreover, miRNA expression correlates with cancers and could have a crucial function in tumor progression.Bioinformatic data indicate that each miRNA can control hundreds of target genes, but identification of the accurate miRNA targets will be crucial to exploit the emerging knowledge of miRNA contribution to cancer process.展开更多
MicroRNAs(miRNAs),which contains approximately 22 nt,belong to a small endogenous,non-coding regulatory single-stranded RNA molecules.They are posttranscriptional regulators of gene expression and highly conserved in ...MicroRNAs(miRNAs),which contains approximately 22 nt,belong to a small endogenous,non-coding regulatory single-stranded RNA molecules.They are posttranscriptional regulators of gene expression and highly conserved in evolution.Many researches show that miRNAs involved in many processes,including tumor formation,cell proliferation and apoptosis and proliferation and metastasis of cancer cells.Among that,the relationship between miRNAs and lung cancer is one of the most focal areas for the researchers,because the abnormal expressions of miRNAs were significantly associated with the occurrence and development of lung cancer.The expression level of different miRNAs in lung cancer cells exist differences,compared with normal lung tissue cells,there are two classes of expression:over-expression level and low expression level.In this review,we focused on studying the mechanism of overexpression miRNAs in lung cancer.展开更多
The so-called split IC quasi-adequate semigroups are in the class of idempotent-connected quasi-adequate semigroups. It is proved that an IC quasi-adequate semigroup is split if and only if it has an adequate transver...The so-called split IC quasi-adequate semigroups are in the class of idempotent-connected quasi-adequate semigroups. It is proved that an IC quasi-adequate semigroup is split if and only if it has an adequate transversal. The structure of such semigroup whose band of idempotents is regular will be particularly investigated. Our obtained results enrich those results given by McAlister and Blyth on split orthodox semigroups.展开更多
文摘A nanometer porphyrin trimer was firstly synthesized with 1 ,3-dibromopropane as a bridge-linked agent and the fluorescence property and thermostability were studied. The results show that the fluorescence property and thermostability of the trimer are different from those of monoporphyrin. The effects of the molecule structure on the optical property and the thermostability were also studied in detail.
文摘MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that are involved in oncogenesis and show remarkable tissue specificity.miRNAs are approximately 22 nt non-coding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or messenger RNA (mRNA) degradation, thus affecting various cellular processes.Since the discovery of their fundamental mechanisms of action, the field of miRNAs has opened a new era in the understanding of small noncoding RNAs.Recent evidence has shown that miRNA controls cell growth, apoptosis, and differentiation.Cancer is a complex genetic disease caused by abnormalities in gene structure and expression, moreover, miRNA expression correlates with cancers and could have a crucial function in tumor progression.Bioinformatic data indicate that each miRNA can control hundreds of target genes, but identification of the accurate miRNA targets will be crucial to exploit the emerging knowledge of miRNA contribution to cancer process.
文摘MicroRNAs(miRNAs),which contains approximately 22 nt,belong to a small endogenous,non-coding regulatory single-stranded RNA molecules.They are posttranscriptional regulators of gene expression and highly conserved in evolution.Many researches show that miRNAs involved in many processes,including tumor formation,cell proliferation and apoptosis and proliferation and metastasis of cancer cells.Among that,the relationship between miRNAs and lung cancer is one of the most focal areas for the researchers,because the abnormal expressions of miRNAs were significantly associated with the occurrence and development of lung cancer.The expression level of different miRNAs in lung cancer cells exist differences,compared with normal lung tissue cells,there are two classes of expression:over-expression level and low expression level.In this review,we focused on studying the mechanism of overexpression miRNAs in lung cancer.
基金Supported by National Natural Science Foundation of China of China(Grant No.10961014)Natural Science Foundation of Jiangxi Provincethe SF of Education Department of Jiangxi Province,China(Grant No.GJJ11388)
文摘The so-called split IC quasi-adequate semigroups are in the class of idempotent-connected quasi-adequate semigroups. It is proved that an IC quasi-adequate semigroup is split if and only if it has an adequate transversal. The structure of such semigroup whose band of idempotents is regular will be particularly investigated. Our obtained results enrich those results given by McAlister and Blyth on split orthodox semigroups.
