The content of berberine hydrochloride(BH)in compound berberine tablets(CBTs)is subject to strict requirements.Its content is usually measured based on chemical analysis.In this paper,the fluorescence spectral imaging...The content of berberine hydrochloride(BH)in compound berberine tablets(CBTs)is subject to strict requirements.Its content is usually measured based on chemical analysis.In this paper,the fluorescence spectral imaging method was used to study the relative content of BH from a physics perspective.By comparing the relative fluorescence intensity of self-made CBTs with di®erent mass percentages of BH,a linear positive relationship was observed between the BH content and the relative fluorescence intensity,and accordingly the quality of CBTs of different brands was evaluated.The results indicate that the fluorescence spectral imaging method can be a simple,fast and nondestructive semi-quantitative analysis method to determine the content of BH in CBTs,and this method has great potential in the quality control of CBTs.展开更多
Functional near-infrared spectroscopy(fNIRS),as a new optical functional neuroimaging method,has been widely used in neuroscience research.In some research fields with NIRS,heartrate(HR)(or heartbeat)is needed as usef...Functional near-infrared spectroscopy(fNIRS),as a new optical functional neuroimaging method,has been widely used in neuroscience research.In some research fields with NIRS,heartrate(HR)(or heartbeat)is needed as useful information to evaluate its influence,or to know the state ofsubject,or to remove its artifact.If HR(or heartbeat)can be detected with high accuracy from theoptical intensity,this will undoubtedly benefit a lot to many NIRS studies.Previous studies haveused the moving time window method or mathematical morphology method(MMM)to detectheartbeats in the optical intensity.However,there are some disadvantages in these methods.In thisstudy,we proposed a method combining the periodic information of heartbeats and the operator ofmathematical morphology to automatically detect heartbeats in the optical intensity.First theoptical intensity is smoothed using a moving average flter.Then,the opening operator of math-ematical morphology extracts peaks in the smoothed optical intensity.Finally,one peak is iden-tified as a heartbeat peak if this peak is the maximum in a predefined point range.Throughvalidation on experimental data,our method can overcome the disadvantages of previous methods,and detet heartbeats in the optical signal of fNIRS with nearly 100%accuracy.展开更多
基金The authors would like to acknowledge the support of the Ph.D.research startup foundation of Guangdong Medical University (2XB14006).
文摘The content of berberine hydrochloride(BH)in compound berberine tablets(CBTs)is subject to strict requirements.Its content is usually measured based on chemical analysis.In this paper,the fluorescence spectral imaging method was used to study the relative content of BH from a physics perspective.By comparing the relative fluorescence intensity of self-made CBTs with di®erent mass percentages of BH,a linear positive relationship was observed between the BH content and the relative fluorescence intensity,and accordingly the quality of CBTs of different brands was evaluated.The results indicate that the fluorescence spectral imaging method can be a simple,fast and nondestructive semi-quantitative analysis method to determine the content of BH in CBTs,and this method has great potential in the quality control of CBTs.
基金support from the PhD research startup foundation of Guangdong Medical University(2XB14006).
文摘Functional near-infrared spectroscopy(fNIRS),as a new optical functional neuroimaging method,has been widely used in neuroscience research.In some research fields with NIRS,heartrate(HR)(or heartbeat)is needed as useful information to evaluate its influence,or to know the state ofsubject,or to remove its artifact.If HR(or heartbeat)can be detected with high accuracy from theoptical intensity,this will undoubtedly benefit a lot to many NIRS studies.Previous studies haveused the moving time window method or mathematical morphology method(MMM)to detectheartbeats in the optical intensity.However,there are some disadvantages in these methods.In thisstudy,we proposed a method combining the periodic information of heartbeats and the operator ofmathematical morphology to automatically detect heartbeats in the optical intensity.First theoptical intensity is smoothed using a moving average flter.Then,the opening operator of math-ematical morphology extracts peaks in the smoothed optical intensity.Finally,one peak is iden-tified as a heartbeat peak if this peak is the maximum in a predefined point range.Throughvalidation on experimental data,our method can overcome the disadvantages of previous methods,and detet heartbeats in the optical signal of fNIRS with nearly 100%accuracy.
