Soft tissue engineering has been developed as a new strategy for repairing damaged or diseased soft tissues and organs to overcome the limitations of current therapies.Since most of soft tissues in the human body are ...Soft tissue engineering has been developed as a new strategy for repairing damaged or diseased soft tissues and organs to overcome the limitations of current therapies.Since most of soft tissues in the human body are usually supported by collagen fibers to form a three-dimensional microstructure,fiber-reinforced scaffolds have the advantage to mimic the structure,mechanical and biological environment of natural soft tissues,which benefits for their regeneration and remodeling.This article reviews and discusses the latest research advances on design and manufacture of novel fiber-reinforced scaffolds for soft tissue repair and how fiber addition affects their structural characteristics,mechanical strength and biological activities in vitro and in vivo.In general,the concept of fiber-reinforced scaffolds with adjustable microstructures,mechanical properties and degradation rates can provide an effective platform and promising method for developing satisfactory biomechanically functional implantations for soft tissue engineering or regenerative medicine.展开更多
基金The authors acknowledge the financial supports from the National Natural Science Foundation of China(Nos.31370959 and 61227902)the National Key Research and Development Program of China(No.2017YFC1104703)+3 种基金Beijing Nova Programme Interdisciplinary Cooperation Project(No.xxjc201616)Fok Ying Tung Education Foundation(No.141039)State Key Laboratory of New Ceramic and Fine Processing Tsinghua University(No.KF201714)International Joint Research Center of Aerospace Biotechnology and Medical Engineering,Ministry of Science and Technology of China,and the 111 Project(No.B13003).
文摘Soft tissue engineering has been developed as a new strategy for repairing damaged or diseased soft tissues and organs to overcome the limitations of current therapies.Since most of soft tissues in the human body are usually supported by collagen fibers to form a three-dimensional microstructure,fiber-reinforced scaffolds have the advantage to mimic the structure,mechanical and biological environment of natural soft tissues,which benefits for their regeneration and remodeling.This article reviews and discusses the latest research advances on design and manufacture of novel fiber-reinforced scaffolds for soft tissue repair and how fiber addition affects their structural characteristics,mechanical strength and biological activities in vitro and in vivo.In general,the concept of fiber-reinforced scaffolds with adjustable microstructures,mechanical properties and degradation rates can provide an effective platform and promising method for developing satisfactory biomechanically functional implantations for soft tissue engineering or regenerative medicine.
